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Computers and Morphology

Computers and Morphology Abstract Computers level of society. In the laboratory, virtually all sophisticated instruments have been coupled with computers to acquire, to display, and to analyze data with speed and accuracy. For those interested in correlating structure with function, the computer affords the opportunity to visualize tissues and their cellular and subcellular components in three dimensions (3-D) and to calculate their two-dimensional (2-D) and 3-D parameters.1 Three-dimensional computer reconstruction of tissues from serial sections represents a major advance in research methodology for the morphologist. The reconstructed tissues can be represented either as wire frame models2 or as solid objects3 depending on the software and hardware available to the investigator. The 3-D computer reconstruction represents the epitome of model making because the models can be dissected and put back together at will without their being damaged or destroyed as may occur with models constructed of plasticene, paper, or plastic. In addition, References 1. Braverman MS, Braverman IM: Three-dimensional reconstructions of objects from serial sections using a microcomputer graphics system . J Invest Dermatol 1986;86:290-294.Crossref 2. Perkins WJ, Green RJ: Three-dimensional reconstruction of biological sections . J Biomed Eng 1982;4:37-43.Crossref 3. Antunez J-CM, Galey FR, Linthicum FH, et al: Computer aided and graphic reconstruction of the human endolymphatic duct and sac . Ann Otol Rhinol Laryngol 1980;89( (suppl 76) ):23-32. 4. Lindelöf B, Forslind B, Hedblad M-A, et al: Morphology revealed by light and scanning electron microscopy and computer aided three-dimensional reconstruction . Arch Dermatol 1988; 124:1359-1363.Crossref 5. Braverman IM, Yen A: Microcirculation in psoriatic skin . J Invest Dermatol 1974;62:493-502.Crossref 6. Braverman IM, Keh-Yen A: Three-dimensional reconstruction of endothelial cell gaps in psoriatic vessels and their morphological identity with gaps produced by the intradermal injection of histamine . J Invest Dermatol 1986;86:577-581.Crossref 7. Majno G, Shea SM, Levinthal M: Endothelial contraction induced by histamine-like mediators: An electron microscopic study . J Cell Biol 1969;42:647-672.Crossref 8. Joyce NC, Haire MF, Palade GF: Contractile proteins in pericytes: I. Immunoperixodase localization of tropomyosin . J Cell Biol 1985;100:1379-1386.Crossref 9. Joyce NC, Haire MF, Palade GF: Contractile proteins in pericytes: II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrations . J Cell Biol 1985; 100:1387-1395.Crossref 10. Braverman IM, Sibley J, Keh-Yen A: A study of veil cells around normal, diabetic and aged cutaneous microvessels . J Invest Dermatol 1986;86:57-62.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Computers and Morphology

Archives of Dermatology , Volume 124 (9) – Sep 1, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670090071016
Publisher site
See Article on Publisher Site

Abstract

Abstract Computers level of society. In the laboratory, virtually all sophisticated instruments have been coupled with computers to acquire, to display, and to analyze data with speed and accuracy. For those interested in correlating structure with function, the computer affords the opportunity to visualize tissues and their cellular and subcellular components in three dimensions (3-D) and to calculate their two-dimensional (2-D) and 3-D parameters.1 Three-dimensional computer reconstruction of tissues from serial sections represents a major advance in research methodology for the morphologist. The reconstructed tissues can be represented either as wire frame models2 or as solid objects3 depending on the software and hardware available to the investigator. The 3-D computer reconstruction represents the epitome of model making because the models can be dissected and put back together at will without their being damaged or destroyed as may occur with models constructed of plasticene, paper, or plastic. In addition, References 1. Braverman MS, Braverman IM: Three-dimensional reconstructions of objects from serial sections using a microcomputer graphics system . J Invest Dermatol 1986;86:290-294.Crossref 2. Perkins WJ, Green RJ: Three-dimensional reconstruction of biological sections . J Biomed Eng 1982;4:37-43.Crossref 3. Antunez J-CM, Galey FR, Linthicum FH, et al: Computer aided and graphic reconstruction of the human endolymphatic duct and sac . Ann Otol Rhinol Laryngol 1980;89( (suppl 76) ):23-32. 4. Lindelöf B, Forslind B, Hedblad M-A, et al: Morphology revealed by light and scanning electron microscopy and computer aided three-dimensional reconstruction . Arch Dermatol 1988; 124:1359-1363.Crossref 5. Braverman IM, Yen A: Microcirculation in psoriatic skin . J Invest Dermatol 1974;62:493-502.Crossref 6. Braverman IM, Keh-Yen A: Three-dimensional reconstruction of endothelial cell gaps in psoriatic vessels and their morphological identity with gaps produced by the intradermal injection of histamine . J Invest Dermatol 1986;86:577-581.Crossref 7. Majno G, Shea SM, Levinthal M: Endothelial contraction induced by histamine-like mediators: An electron microscopic study . J Cell Biol 1969;42:647-672.Crossref 8. Joyce NC, Haire MF, Palade GF: Contractile proteins in pericytes: I. Immunoperixodase localization of tropomyosin . J Cell Biol 1985;100:1379-1386.Crossref 9. Joyce NC, Haire MF, Palade GF: Contractile proteins in pericytes: II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrations . J Cell Biol 1985; 100:1387-1395.Crossref 10. Braverman IM, Sibley J, Keh-Yen A: A study of veil cells around normal, diabetic and aged cutaneous microvessels . J Invest Dermatol 1986;86:57-62.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1988

References