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Computerized Tomography in Progressive Multifocal Leukoencephalopathy

Computerized Tomography in Progressive Multifocal Leukoencephalopathy Abstract Progressive multifocal leukoencephalopathy (PML) is an uncommon, subacute demyelinating disorder of the central nervous system (CNS) of viral cause, which affects immunologically compromised patients. The diagnosis rests on the histopathologic examination of CNS tissue, since laboratory methods yield consistently negative results.1 Computerized tomography (CT), with its ability to delineate abnormal tissue densities within brain parenchyma, may prove to be useful in this disorder. Paxton and Ambrose2 reported a CT scan with an ill-defined low density area in the right frontal lobe of a patient with biopsyproven PML. Our report describes a patient with PML in whom clinicopathologic correlation with an abnormal CT scan was obtained. Report of a Case.— A 54-year-old man was admitted to the University of Iowa Hospitals in December 1974 because of visual impairment on the right. Two years before, lymphocytic lymphoma (stage IV) had been diagnosed. He was treated with various chemotherapeutic regimens with no lasting References 1. Richardson EP: Our evolving understanding of progressive multifocal leukoencephalopathy . Ann NY Acad Sci 230:358-364, 1974.Crossref 2. Paxton R, Ambrose J: The EMI Scanner: A brief review of the first 650 patients . Br J Radiol 47:530-565, 1974.Crossref 3. Fields SW, Bell RM, Campbell JK, et al: Computed tomography in the management of cerebrovascular disease . Stroke 6:105-107, 1975. 4. Astrom KE, Mancall EL, Richardson EP: Progressive multifocal leukoencephalopathy . Brain 81:93-111, 1958.Crossref 5. Williams HM, Diamond HD, Craver LF, et al: Neurologic Complications of Lymphomas and Leukemias . Springfield, Ill, Charles C Thomas Publisher, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Computerized Tomography in Progressive Multifocal Leukoencephalopathy

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Computerized Tomography in Progressive Multifocal Leukoencephalopathy

Abstract

Abstract Progressive multifocal leukoencephalopathy (PML) is an uncommon, subacute demyelinating disorder of the central nervous system (CNS) of viral cause, which affects immunologically compromised patients. The diagnosis rests on the histopathologic examination of CNS tissue, since laboratory methods yield consistently negative results.1 Computerized tomography (CT), with its ability to delineate abnormal tissue densities within brain parenchyma, may prove to be useful in this disorder....
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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1976.00500030072019
Publisher site
See Article on Publisher Site

Abstract

Abstract Progressive multifocal leukoencephalopathy (PML) is an uncommon, subacute demyelinating disorder of the central nervous system (CNS) of viral cause, which affects immunologically compromised patients. The diagnosis rests on the histopathologic examination of CNS tissue, since laboratory methods yield consistently negative results.1 Computerized tomography (CT), with its ability to delineate abnormal tissue densities within brain parenchyma, may prove to be useful in this disorder. Paxton and Ambrose2 reported a CT scan with an ill-defined low density area in the right frontal lobe of a patient with biopsyproven PML. Our report describes a patient with PML in whom clinicopathologic correlation with an abnormal CT scan was obtained. Report of a Case.— A 54-year-old man was admitted to the University of Iowa Hospitals in December 1974 because of visual impairment on the right. Two years before, lymphocytic lymphoma (stage IV) had been diagnosed. He was treated with various chemotherapeutic regimens with no lasting References 1. Richardson EP: Our evolving understanding of progressive multifocal leukoencephalopathy . Ann NY Acad Sci 230:358-364, 1974.Crossref 2. Paxton R, Ambrose J: The EMI Scanner: A brief review of the first 650 patients . Br J Radiol 47:530-565, 1974.Crossref 3. Fields SW, Bell RM, Campbell JK, et al: Computed tomography in the management of cerebrovascular disease . Stroke 6:105-107, 1975. 4. Astrom KE, Mancall EL, Richardson EP: Progressive multifocal leukoencephalopathy . Brain 81:93-111, 1958.Crossref 5. Williams HM, Diamond HD, Craver LF, et al: Neurologic Complications of Lymphomas and Leukemias . Springfield, Ill, Charles C Thomas Publisher, 1959.

Journal

Archives of Neurology – American Medical Association

Published: Mar 1, 1976

References

  • Our evolving understanding of progressive multifocal leukoencephalopathy
    Richardson EP
  • The EMI Scanner: A brief review of the first 650 patients
    Paxton R, Ambrose J
  • Computed tomography in the management of cerebrovascular disease
    Fields SW, Bell RM, Campbell JK, et al
  • Progressive multifocal leukoencephalopathy
    Astrom KE, Mancall EL, Richardson EP
  • Neurologic Complications of Lymphomas and Leukemias
    Williams HM, Diamond HD, Craver LF, et al