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Computed Tomographic Colonography to Screen for Colorectal Cancer, Extracolonic Cancer, and Aortic Aneurysm

Computed Tomographic Colonography to Screen for Colorectal Cancer, Extracolonic Cancer, and... ORIGINAL INVESTIGATION Computed Tomographic Colonography to Screen for Colorectal Cancer, Extracolonic Cancer, and Aortic Aneurysm Model Simulation With Cost-effectiveness Analysis Cesare Hassan, MD; Perry Pickhardt, MD; Andrea Laghi, MD; Daniel Kim, MD; Angelo Zullo, MD; Franco Iafrate, MD; Lorenzo Di Giulio, MD; Sergio Morini, MD Background: In addition to detecting colorectal neo- due to a decrease in AAA-related deaths, whereas the mod- plasia, abdominal computed tomography (CT) with colo- eled benefit from extracolonic cancer downstaging was a nography technique (CTC) can also detect unsuspected relatively minor factor. At sensitivity analysis, OC-US be- extracolonic cancers and abdominal aortic aneurysms came more cost-effective only when the CTC sensitivity for (AAA). The efficacy and cost-effectiveness of this com- large polyps dropped to 61% or when broad variations of bined abdominal CT screening strategy are unknown. costs were simulated, such as an increase in CTC cost from $814 to $1300 or a decrease in OC cost from $1100 to $500. Methods: A computerized Markov model was con- With the OC-US approach, suboptimal compliance had a structed to simulate the occurrence of colorectal neopla- strong negative influence on efficacy and cost- sia, extracolonic malignant neoplasm, and AAA in a hy- effectiveness. The estimated mortality http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Computed Tomographic Colonography to Screen for Colorectal Cancer, Extracolonic Cancer, and Aortic Aneurysm

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References (100)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.168.7.696
pmid
18413551
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Computed Tomographic Colonography to Screen for Colorectal Cancer, Extracolonic Cancer, and Aortic Aneurysm Model Simulation With Cost-effectiveness Analysis Cesare Hassan, MD; Perry Pickhardt, MD; Andrea Laghi, MD; Daniel Kim, MD; Angelo Zullo, MD; Franco Iafrate, MD; Lorenzo Di Giulio, MD; Sergio Morini, MD Background: In addition to detecting colorectal neo- due to a decrease in AAA-related deaths, whereas the mod- plasia, abdominal computed tomography (CT) with colo- eled benefit from extracolonic cancer downstaging was a nography technique (CTC) can also detect unsuspected relatively minor factor. At sensitivity analysis, OC-US be- extracolonic cancers and abdominal aortic aneurysms came more cost-effective only when the CTC sensitivity for (AAA). The efficacy and cost-effectiveness of this com- large polyps dropped to 61% or when broad variations of bined abdominal CT screening strategy are unknown. costs were simulated, such as an increase in CTC cost from $814 to $1300 or a decrease in OC cost from $1100 to $500. Methods: A computerized Markov model was con- With the OC-US approach, suboptimal compliance had a structed to simulate the occurrence of colorectal neopla- strong negative influence on efficacy and cost- sia, extracolonic malignant neoplasm, and AAA in a hy- effectiveness. The estimated mortality

Journal

JAMA Internal Medicine – American Medical Association

Published: Apr 14, 2008

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