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Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission... Key PointsQuestionHow do plasma phosphorylated tau (p-tau) 181 and p-tau231 as measured on the single-molecule array (Simoa) platform and p-tau181 and p-tau217 as measured on the Meso Scale Discovery (MSD) platform compare with regards to amyloid and tau positron emission tomography and magnetic resonance imaging measures as well as cognition? FindingsIn this cross-sectional study including 200 participants, MSD p-tau181 and p-tau217 predicted entorhinal cortex tau positron emission tomography measures significantly better than Simoa p-tau181 among cognitively unimpaired participants. MSD p-tau181 and p-tau217 and Simoa p-tau181, but not p-tau231, were associated with magnetic resonance imaging measures of cerebrovascular pathology, and MSD p-tau181 and p-tau217 were most strongly associated with magnetic resonance imaging measures of Alzheimer disease pathology. MeaningResults from this study suggest subtle differences across plasma p-tau species and platforms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2021.2293
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionHow do plasma phosphorylated tau (p-tau) 181 and p-tau231 as measured on the single-molecule array (Simoa) platform and p-tau181 and p-tau217 as measured on the Meso Scale Discovery (MSD) platform compare with regards to amyloid and tau positron emission tomography and magnetic resonance imaging measures as well as cognition? FindingsIn this cross-sectional study including 200 participants, MSD p-tau181 and p-tau217 predicted entorhinal cortex tau positron emission tomography measures significantly better than Simoa p-tau181 among cognitively unimpaired participants. MSD p-tau181 and p-tau217 and Simoa p-tau181, but not p-tau231, were associated with magnetic resonance imaging measures of cerebrovascular pathology, and MSD p-tau181 and p-tau217 were most strongly associated with magnetic resonance imaging measures of Alzheimer disease pathology. MeaningResults from this study suggest subtle differences across plasma p-tau species and platforms.

Journal

JAMA NeurologyAmerican Medical Association

Published: Sep 26, 2021

References