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Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With... JOBNAME: JAMA XML PAGE: 1 SESS: 10 OUTPUT: Wed Jan 6 09:15:45 2010 DATE: 01/05/10 TIME: 16:03 USER: thutchis /jama/10jobs/weekly/27jan10/joc90147 DRAFT ORIGINAL CONTRIBUTION Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation A Randomized Controlled Trial David J. Wilber, MD Context Antiarrhythmic drugs are commonly used for prevention of recurrent atrial Carlo Pappone, MD, PhD fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF. Petr Neuzil, MD Objective To determine the efficacy of catheter ablation compared with antiarrhyth- Angelo De Paola, MD mic drug therapy (ADT) in treating symptomatic paroxysmal AF. Frank Marchlinski, MD Design, Setting, Participants A prospective, multicenter, randomized (2:1), un- Andrea Natale, MD blinded, Bayesian-designed study conducted at 19 hospitals of 167 patients who failed at least 1 antiarrhythmic drug and who experienced at least 3 AF episodes within 6 Laurent Macle, MD months before randomization. Enrollment occurred between October 25, 2004, and Emile G. Daoud, MD October 11, 2007, with the last follow-up on January 19, 2009. Hugh Calkins, MD Intervention Catheter ablation (n = 106) or ADT (n = 61), with assessment for ef- Burr Hall, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.2029
pmid
20103757
Publisher site
See Article on Publisher Site

Abstract

JOBNAME: JAMA XML PAGE: 1 SESS: 10 OUTPUT: Wed Jan 6 09:15:45 2010 DATE: 01/05/10 TIME: 16:03 USER: thutchis /jama/10jobs/weekly/27jan10/joc90147 DRAFT ORIGINAL CONTRIBUTION Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation A Randomized Controlled Trial David J. Wilber, MD Context Antiarrhythmic drugs are commonly used for prevention of recurrent atrial Carlo Pappone, MD, PhD fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF. Petr Neuzil, MD Objective To determine the efficacy of catheter ablation compared with antiarrhyth- Angelo De Paola, MD mic drug therapy (ADT) in treating symptomatic paroxysmal AF. Frank Marchlinski, MD Design, Setting, Participants A prospective, multicenter, randomized (2:1), un- Andrea Natale, MD blinded, Bayesian-designed study conducted at 19 hospitals of 167 patients who failed at least 1 antiarrhythmic drug and who experienced at least 3 AF episodes within 6 Laurent Macle, MD months before randomization. Enrollment occurred between October 25, 2004, and Emile G. Daoud, MD October 11, 2007, with the last follow-up on January 19, 2009. Hugh Calkins, MD Intervention Catheter ablation (n = 106) or ADT (n = 61), with assessment for ef- Burr Hall,

Journal

JAMAAmerican Medical Association

Published: Jan 27, 2010

References