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Comparing Painful Stimulation vs Rest in Studies of Pain—Reply

Comparing Painful Stimulation vs Rest in Studies of Pain—Reply Letters cohort was very low and, as mentioned in our article, mortal- Comparing Painful Stimulation vs Rest ity was never directly associated with stroke. in Studies of Pain Goh and Sivakumaran suggest that assessing neurological To the Editor A recent Research Letter in JAMA Neurology pre- outcome via the validated Pediatric Stroke Outcome Measure sented results of a functional magnetic resonance imaging (PSOM) is “a surrogate marker,” presumably for mortality. Neu- study of individuals with rare loss-of-function SCN9A rologicalfunctionisnotasurrogateoutcomeformortality.Rather, mutations that abolish sensory neuron sodium channel Nav1.7 the PSOM is a different outcome measured in stroke survivors activity, resulting in congenital pain insensitivity. The study and is an appropriate outcome in pediatric stroke studies because compared brain responses to a brief pinprick stimulus be- most children survive. Mortality after pediatric AIS in a large tween patients (n = 2) and control individuals (n = 4). The au- retrospective population-based cohort (N = 124 with stroke of thors reported activation of areas that have previously been 2.3 million children) was 4%. In our study, 11 of 98 children implicated in pain processing and observed “no significant dif- (11%) died. Mortality is not the correct primary outcome for ference between patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Comparing Painful Stimulation vs Rest in Studies of Pain—Reply

JAMA Neurology , Volume 73 (10) – Oct 29, 2016

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Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2016.2992
pmid
27571248
Publisher site
See Article on Publisher Site

Abstract

Letters cohort was very low and, as mentioned in our article, mortal- Comparing Painful Stimulation vs Rest ity was never directly associated with stroke. in Studies of Pain Goh and Sivakumaran suggest that assessing neurological To the Editor A recent Research Letter in JAMA Neurology pre- outcome via the validated Pediatric Stroke Outcome Measure sented results of a functional magnetic resonance imaging (PSOM) is “a surrogate marker,” presumably for mortality. Neu- study of individuals with rare loss-of-function SCN9A rologicalfunctionisnotasurrogateoutcomeformortality.Rather, mutations that abolish sensory neuron sodium channel Nav1.7 the PSOM is a different outcome measured in stroke survivors activity, resulting in congenital pain insensitivity. The study and is an appropriate outcome in pediatric stroke studies because compared brain responses to a brief pinprick stimulus be- most children survive. Mortality after pediatric AIS in a large tween patients (n = 2) and control individuals (n = 4). The au- retrospective population-based cohort (N = 124 with stroke of thors reported activation of areas that have previously been 2.3 million children) was 4%. In our study, 11 of 98 children implicated in pain processing and observed “no significant dif- (11%) died. Mortality is not the correct primary outcome for ference between patients

Journal

JAMA NeurologyAmerican Medical Association

Published: Oct 29, 2016

References