Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Comparative Studies of Rubella Vaccines

Comparative Studies of Rubella Vaccines Abstract IN 1966 Parkman, Meyer, and colleagues1,2 attenuated rubella virus by 77 passages in primary African green monkey kidney (GMK) cell culture and began to evaluate this strain (HPV-77) as a vaccine. Since that time, a number of attenuated rubella strains have been derived from HPV-77. Among these, three have emerged as major vaccine candidates: HPV-77 passaged five times in duck embryo fibroblast cell culture (HPV-77DE5)3,4; HPV-77 passaged 12 times in dog kidney cell culture (HPV-77DK12)5; and HPV-77 passaged three additional times in primary GMK cell culture (HPV-80) (according to a written communication from R. N. Hull, PhD, in June 1969). In addition, an attenuated strain of rubella virus (Cendehill) has been developed by 51 passages in primary rabbit kidney cell culture.6-8 Studies with these vaccines have established that they are immunogenic and attenuated when used in children, and that, although shed in the pharynx, References 1. Parkman, P.D., et al: Attenuated Rubella Virus: I. Development and Laboratory Characterization , New Eng J Med 275:569-574 ( (Sept) ) 1966.Crossref 2. Meyer, H.M., Jr.; Parkman, P.D.; and Panos, T.C.: Attenuated Rubella Virus: II. Production of an Experimental Live-Virus Vaccine and Clinical Trial , New Eng J Med 275:575-580 ( (Sept) ) 1966Crossref 3. Buynak, E.B., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: I. Development and Clinical Testing , JAMA 204:195-200 ( (April 15) ) 1968.Crossref 4. Weibel, R.E., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: II. Clinical Tests in Families and in an Institution , JAMA 205:554-558 ( (Aug 19) ) 1968.Crossref 5. Musser, S.: Production of Rubella Virus Vaccine: Live, Attenuated in Canine Kidney Cell Cultures, Proceedings of the International Conference on Rubella Immunization, Bethesda, Md, Feb 18-20, 1969 , Amer J Dis Child 118:334-337 ( (Aug) ) 1969.Crossref 6. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21:133-143 ( (Sept) ) 1967.Crossref 7. Huygelen, C., and Peetermans, J.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: II. Experiments in Animals , Arch Ges Virusforsch 21:357-365 ( (Nov) ) 1967.Crossref 8. Du Pan, M.R., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine: Cendehill 51 Strain , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref 9. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine-Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 10. Cooper, L.Z.; Giles, J.P.; and Krugman, S.: Clinical Trial of Live Attenuated Rubella Virus Vaccine, HPV-77 Strain , Amer J Dis Child 115: 655-657 ( (June) ) 1968. 11. Lepow, M.L., et al: A Trial With Live Attenuated Rubella Vaccine , Amer J Dis Child 115: 639-647 ( (June) ) 1968. 12. Parkman, P.D., and Meyer, H.M., Jr.: Prospects for a Rubella Virus Vaccine, Prospect Med Virol, to be published. 13. Parkman, P.D., et al: Studies of Rubella: I. Properties of the Virus , J Immun 93:595-607 ( (Oct) ) 1964. 14. Reed, L.J., and Muench, H.A.: A Simple Method of Estimating Fifty Percent End Points , Amer J Hyg 27:493-497 ( (May) ) 1938. 15. Halonen, P.E.; Ryan, J.M.; and Stewart, J.A.: Rubella Hemagglutinin Prepared With Alkaline Extraction of Virus Grown in Suspension Culture of BHK-21 Cells , Proc Soc Exp Biol Med 125: 162-167 ( (May) ) 1967.Crossref 16. Halonen, P.E.; Stewart, J.A.; and Hall, A.D.: Rubella Hemagglutinin Prepared in Serum Free Suspension Culture of BHK-21 Cells , Ann Med Exp Biol Fenn 45:182-185, 1967. 17. Stewart, G.L., et al: Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March) ) 1967.Crossref 18. Rafajko, R.R., et al: Stability of Rubella Hemagglutinin , Appl Microbiol 16:423 ( (Feb) ) 1968. 19. Meyer, H.M., Jr., et al: Clinical Studies With Attenuated Rubella Virus, International Conference on Vaccines Against Viral and Rickettsial Diseases of Man, 1966, Pan American Health Organization and World Health Organization, Scientific Publication No. 147, 1967, p 390. 20. Krugman, S., et al: Studies on Immunity to Measles , J Pediat 66:471-488 ( (March) ) 1965.Crossref 21. Fry, J.; Dillane, J.B.; and Fry, L.: Rubella, 1962 , Brit Med J 2:833-834 ( (Sept) ) 1962.Crossref 22. Phillips, C.A., et al: Isolation of Rubella Virus , JAMA 191:615-618 ( (Feb 22) ) 1965.Crossref 23. Brody, J.A., et al: Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: I. Epidemiologic, Clinical, and Serologic Findings , JAMA 191:619-623 ( (Feb 22) ) 1965.Crossref 24. Cooper, L.Z., et al: " Arthritis Following Immunization With Rubella Vaccines ," in Proceedings of the 23rd Symposium on Microbiologic Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Loading next page...
 
/lp/american-medical-association/comparative-studies-of-rubella-vaccines-Gvx9ezA0Xw
Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040199007
Publisher site
See Article on Publisher Site

Abstract

Abstract IN 1966 Parkman, Meyer, and colleagues1,2 attenuated rubella virus by 77 passages in primary African green monkey kidney (GMK) cell culture and began to evaluate this strain (HPV-77) as a vaccine. Since that time, a number of attenuated rubella strains have been derived from HPV-77. Among these, three have emerged as major vaccine candidates: HPV-77 passaged five times in duck embryo fibroblast cell culture (HPV-77DE5)3,4; HPV-77 passaged 12 times in dog kidney cell culture (HPV-77DK12)5; and HPV-77 passaged three additional times in primary GMK cell culture (HPV-80) (according to a written communication from R. N. Hull, PhD, in June 1969). In addition, an attenuated strain of rubella virus (Cendehill) has been developed by 51 passages in primary rabbit kidney cell culture.6-8 Studies with these vaccines have established that they are immunogenic and attenuated when used in children, and that, although shed in the pharynx, References 1. Parkman, P.D., et al: Attenuated Rubella Virus: I. Development and Laboratory Characterization , New Eng J Med 275:569-574 ( (Sept) ) 1966.Crossref 2. Meyer, H.M., Jr.; Parkman, P.D.; and Panos, T.C.: Attenuated Rubella Virus: II. Production of an Experimental Live-Virus Vaccine and Clinical Trial , New Eng J Med 275:575-580 ( (Sept) ) 1966Crossref 3. Buynak, E.B., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: I. Development and Clinical Testing , JAMA 204:195-200 ( (April 15) ) 1968.Crossref 4. Weibel, R.E., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: II. Clinical Tests in Families and in an Institution , JAMA 205:554-558 ( (Aug 19) ) 1968.Crossref 5. Musser, S.: Production of Rubella Virus Vaccine: Live, Attenuated in Canine Kidney Cell Cultures, Proceedings of the International Conference on Rubella Immunization, Bethesda, Md, Feb 18-20, 1969 , Amer J Dis Child 118:334-337 ( (Aug) ) 1969.Crossref 6. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21:133-143 ( (Sept) ) 1967.Crossref 7. Huygelen, C., and Peetermans, J.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: II. Experiments in Animals , Arch Ges Virusforsch 21:357-365 ( (Nov) ) 1967.Crossref 8. Du Pan, M.R., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine: Cendehill 51 Strain , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref 9. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine-Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 10. Cooper, L.Z.; Giles, J.P.; and Krugman, S.: Clinical Trial of Live Attenuated Rubella Virus Vaccine, HPV-77 Strain , Amer J Dis Child 115: 655-657 ( (June) ) 1968. 11. Lepow, M.L., et al: A Trial With Live Attenuated Rubella Vaccine , Amer J Dis Child 115: 639-647 ( (June) ) 1968. 12. Parkman, P.D., and Meyer, H.M., Jr.: Prospects for a Rubella Virus Vaccine, Prospect Med Virol, to be published. 13. Parkman, P.D., et al: Studies of Rubella: I. Properties of the Virus , J Immun 93:595-607 ( (Oct) ) 1964. 14. Reed, L.J., and Muench, H.A.: A Simple Method of Estimating Fifty Percent End Points , Amer J Hyg 27:493-497 ( (May) ) 1938. 15. Halonen, P.E.; Ryan, J.M.; and Stewart, J.A.: Rubella Hemagglutinin Prepared With Alkaline Extraction of Virus Grown in Suspension Culture of BHK-21 Cells , Proc Soc Exp Biol Med 125: 162-167 ( (May) ) 1967.Crossref 16. Halonen, P.E.; Stewart, J.A.; and Hall, A.D.: Rubella Hemagglutinin Prepared in Serum Free Suspension Culture of BHK-21 Cells , Ann Med Exp Biol Fenn 45:182-185, 1967. 17. Stewart, G.L., et al: Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March) ) 1967.Crossref 18. Rafajko, R.R., et al: Stability of Rubella Hemagglutinin , Appl Microbiol 16:423 ( (Feb) ) 1968. 19. Meyer, H.M., Jr., et al: Clinical Studies With Attenuated Rubella Virus, International Conference on Vaccines Against Viral and Rickettsial Diseases of Man, 1966, Pan American Health Organization and World Health Organization, Scientific Publication No. 147, 1967, p 390. 20. Krugman, S., et al: Studies on Immunity to Measles , J Pediat 66:471-488 ( (March) ) 1965.Crossref 21. Fry, J.; Dillane, J.B.; and Fry, L.: Rubella, 1962 , Brit Med J 2:833-834 ( (Sept) ) 1962.Crossref 22. Phillips, C.A., et al: Isolation of Rubella Virus , JAMA 191:615-618 ( (Feb 22) ) 1965.Crossref 23. Brody, J.A., et al: Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: I. Epidemiologic, Clinical, and Serologic Findings , JAMA 191:619-623 ( (Feb 22) ) 1965.Crossref 24. Cooper, L.Z., et al: " Arthritis Following Immunization With Rubella Vaccines ," in Proceedings of the 23rd Symposium on Microbiologic Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

References