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Comparative Serological Changes Following Treated Group A Streptococcal Pharyngitis

Comparative Serological Changes Following Treated Group A Streptococcal Pharyngitis Abstract Sequential serum samples from 100 children with documented group A streptococcal pharyngitis treated with orally given penicillin were examined with antistreptolysin and Streptozyme tests. The Streptozyme test was positive with all sera with antistreptolysin titers [unk] 166 Todd units. Serum samples showing low antistreptolysin and elevated Streptozyme titers had an increased antihyaluronidase or antideoxyribonuclease B titer, or both, in more than 50% of the cases. Patients with low initial antistreptolysin and Streptozyme titers, on reexamination one month later, exhibited statistically significant titer increase. These levels, however, still remained below the accepted "normal" levels. References 1. Klein GC, Jones WL: Comparison of the Streptozyme test with the antistreptolysin O, antideoxyribonuclease B and antihyaluronidase tests . Appl Microbiol 21:257-259, 1971. 2. Janeff J, et al: A screening test for streptococcal antibodies . Lab Med 2:38-40, 1971. 3. Collins OD III: Antistreptolysin O determination by sheep cell agglutination . Am J Clin Pathol 57:598-602, 1972. 4. Ofek I, et al: Antibody tests in streptococcal pharyngitis: Streptozyme versus conventional methods . Clin Pediatr 12:341-344, 1973. 5. Bergner-Rabinowitz S, et al: Evaluation of Streptozyme and antistreptolysin O tests in streptococcal pyodermal nephritis . Appl Microbiol 26:56-58, 1973. 6. Breese BB, et al: Beta hemolytic streptococcal infection . Am J Dis Child 119:18-26, 1970.Crossref 7. Rantz LA, Randall E: A modification of the technique for determination of the antistreptolysin titer . Proc Soc Exp Biol Med 59:22-25, 1945.Crossref 8. Klein GC, et al: Microantistreptolysin O test . Appl Microbiol 16:184, 1968. 9. Klein GC, et al: Microtest for streptococcal antideoxyribonuclease B . Appl Microbiol 18:204-206, 1969. 10. Klein GC, Baker CN, Jones WL: Upper limits of normal streptolysin O and antideoxyribonuclease B titers . Appl Microbiol 21:999-1001, 1971. 11. Kaplan EL, et al: The influence of the site of infection on the immune response to group A streptococci . J Clin Invest 49:1405-1414, 1970.Crossref 12. Kaplan EL, et al: Diagnosis of streptococcal pharyngitis: Differentiation of active infection from the carrier state in the symptomatic child . J Infect Dis 123:490-501, 1971.Crossref 13. Szekely A: Streptococcal antibody level in acute rheumatic fever . Acta Paediatr Acad Sci Hung 12:173-181, 1971. 14. Kilbourne ED, Lodge JP: The comparative effects of continuous and intermittent penicillin therapy on the formation of antistreptolysin in hemolytic streptococcal pharyngitis . J Clin Invest 27:418-424, 1948.Crossref 15. Weinstein L, Tsao CCL: Effect of types of treatment on development of antistreptolysin in patients with scarlet fever . Proc Soc Exp Biol Med 63:449-450, 1946.Crossref 16. Rantz LA, Maloney M, Di Caprio JM: Antistreptolysin O responses following hemolytic streptococcus infection in early childhood . Arch Intern Med 87:360-371, 1951. 17. Wannamaker LW: Perplexity and precision in the diagnosis of streptococcal pharyngitis . Am J Dis Child 124:352-358, 1972. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Comparative Serological Changes Following Treated Group A Streptococcal Pharyngitis

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1974.02110230044006
Publisher site
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Abstract

Abstract Sequential serum samples from 100 children with documented group A streptococcal pharyngitis treated with orally given penicillin were examined with antistreptolysin and Streptozyme tests. The Streptozyme test was positive with all sera with antistreptolysin titers [unk] 166 Todd units. Serum samples showing low antistreptolysin and elevated Streptozyme titers had an increased antihyaluronidase or antideoxyribonuclease B titer, or both, in more than 50% of the cases. Patients with low initial antistreptolysin and Streptozyme titers, on reexamination one month later, exhibited statistically significant titer increase. These levels, however, still remained below the accepted "normal" levels. References 1. Klein GC, Jones WL: Comparison of the Streptozyme test with the antistreptolysin O, antideoxyribonuclease B and antihyaluronidase tests . Appl Microbiol 21:257-259, 1971. 2. Janeff J, et al: A screening test for streptococcal antibodies . Lab Med 2:38-40, 1971. 3. Collins OD III: Antistreptolysin O determination by sheep cell agglutination . Am J Clin Pathol 57:598-602, 1972. 4. Ofek I, et al: Antibody tests in streptococcal pharyngitis: Streptozyme versus conventional methods . Clin Pediatr 12:341-344, 1973. 5. Bergner-Rabinowitz S, et al: Evaluation of Streptozyme and antistreptolysin O tests in streptococcal pyodermal nephritis . Appl Microbiol 26:56-58, 1973. 6. Breese BB, et al: Beta hemolytic streptococcal infection . Am J Dis Child 119:18-26, 1970.Crossref 7. Rantz LA, Randall E: A modification of the technique for determination of the antistreptolysin titer . Proc Soc Exp Biol Med 59:22-25, 1945.Crossref 8. Klein GC, et al: Microantistreptolysin O test . Appl Microbiol 16:184, 1968. 9. Klein GC, et al: Microtest for streptococcal antideoxyribonuclease B . Appl Microbiol 18:204-206, 1969. 10. Klein GC, Baker CN, Jones WL: Upper limits of normal streptolysin O and antideoxyribonuclease B titers . Appl Microbiol 21:999-1001, 1971. 11. Kaplan EL, et al: The influence of the site of infection on the immune response to group A streptococci . J Clin Invest 49:1405-1414, 1970.Crossref 12. Kaplan EL, et al: Diagnosis of streptococcal pharyngitis: Differentiation of active infection from the carrier state in the symptomatic child . J Infect Dis 123:490-501, 1971.Crossref 13. Szekely A: Streptococcal antibody level in acute rheumatic fever . Acta Paediatr Acad Sci Hung 12:173-181, 1971. 14. Kilbourne ED, Lodge JP: The comparative effects of continuous and intermittent penicillin therapy on the formation of antistreptolysin in hemolytic streptococcal pharyngitis . J Clin Invest 27:418-424, 1948.Crossref 15. Weinstein L, Tsao CCL: Effect of types of treatment on development of antistreptolysin in patients with scarlet fever . Proc Soc Exp Biol Med 63:449-450, 1946.Crossref 16. Rantz LA, Maloney M, Di Caprio JM: Antistreptolysin O responses following hemolytic streptococcus infection in early childhood . Arch Intern Med 87:360-371, 1951. 17. Wannamaker LW: Perplexity and precision in the diagnosis of streptococcal pharyngitis . Am J Dis Child 124:352-358, 1972.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Apr 1, 1974

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