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Comparative Efficacy of Theophylline and Caffeine in the Treatment of Idiopathic Apnea in Premature Infants

Comparative Efficacy of Theophylline and Caffeine in the Treatment of Idiopathic Apnea in... Abstract • The purpose of our prospective randomized study was to compare the efficacy of theophylline ethylenediamine and caffeine sodium citrate in the treatment of idiopathic apnea in premature infants. Sixteen infants with three or more severe apneic attacks were studied. Twenty-four-hour cardiorespiratory recordings immediately before and after randomization and four days later showed similar significant decreases of the apnea frequency in both theophylline- (group 1, n=8) and caffeine-treated infants (group 2, n=8). No undesirable side effects were observed, except for tachycardia in one infant in group 1. We suggest reasons for preferring caffeine to theophylline in the control of idiopathic apnea in premature infants: caffeine is as efficient and easier to administer. (AJDC 1985;139:698-700) References 1. Aranda JV, Turmen T: Methylxanthines in apnea of prematurity . Clin Perinatol 1979;6:87-108. 2. Simons FER, Rigatto H, Simons KJ: Pharmacokinetics of theophylline in neonates . Sem Perinatol 1981;5:337-345. 3. Murat I, Moriette G, Blin MC, et al: The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants . J Pediatr 1981;99:984-989.Crossref 4. Midha KK, Sved S, Hossier RD, et al: Highperformance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma . Biomed Mass Spectrom 1977;4:172.Crossref 5. Bory C, Baltassat P, Porthault M, et al: Metabolism of theophylline to caffeine in premature newborn infants . J Pediatr 1979;94:988-993.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Comparative Efficacy of Theophylline and Caffeine in the Treatment of Idiopathic Apnea in Premature Infants

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1985.02140090060028
Publisher site
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Abstract

Abstract • The purpose of our prospective randomized study was to compare the efficacy of theophylline ethylenediamine and caffeine sodium citrate in the treatment of idiopathic apnea in premature infants. Sixteen infants with three or more severe apneic attacks were studied. Twenty-four-hour cardiorespiratory recordings immediately before and after randomization and four days later showed similar significant decreases of the apnea frequency in both theophylline- (group 1, n=8) and caffeine-treated infants (group 2, n=8). No undesirable side effects were observed, except for tachycardia in one infant in group 1. We suggest reasons for preferring caffeine to theophylline in the control of idiopathic apnea in premature infants: caffeine is as efficient and easier to administer. (AJDC 1985;139:698-700) References 1. Aranda JV, Turmen T: Methylxanthines in apnea of prematurity . Clin Perinatol 1979;6:87-108. 2. Simons FER, Rigatto H, Simons KJ: Pharmacokinetics of theophylline in neonates . Sem Perinatol 1981;5:337-345. 3. Murat I, Moriette G, Blin MC, et al: The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants . J Pediatr 1981;99:984-989.Crossref 4. Midha KK, Sved S, Hossier RD, et al: Highperformance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma . Biomed Mass Spectrom 1977;4:172.Crossref 5. Bory C, Baltassat P, Porthault M, et al: Metabolism of theophylline to caffeine in premature newborn infants . J Pediatr 1979;94:988-993.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jul 1, 1985

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