Abstract • Antipyretics should be employed in the pediatric population whenever it is the clinical judgment of the attending physician that fever should be lowered. Aspirin and acetaminophen are equally effective as antipyretics. The efficacy and safety of these two most common antipyretic agents are examined, and various studies with these agents are critically reviewed. Since acetaminophen has a greater margin of safety at antipyretic dosages, it is preferred to aspirin when an anti-inflammatory effect is not required. The efficacy and safety of combination therapy with acetaminophen and aspirin in pediatric patients—or an alternative treatment regimen with both these drugs—warrant investigation. (Arch Intern Med 1981;141:286-292) References 1. Lovejoy FH Jr: Aspirin and acetaminophen: A comparative view of their antipyretic and analgesic activity. Pediatrics 1978;62( (suppl) ):904-909. 2. Done AK: Antipyretics. Pediatr Clin North Am 1972;19:167-177. 3. Cornely DA, Ritter JA: N-Acetyl-p-aminophenol (Tylenol elixir) as pediatric antipyreticanalgesic. JAMA 1956;160:1219-1221.Crossref 4. Colgan MT, Mintz AA: The comparative antipyretic effect of N-acetyl-p-aminophenol and acetylsalicylic acid. J Pediatr 1957;50:552-555.Crossref 5. Eden AN, Kaufman A: Clinical comparison of three antipyretic agents. Am J Dis Child 1967;114:284-287. 6. Steele RW, Tanaka PT, Lara RP, et al: Evaluation of sponging and of oral antipyretic therapy to reduce fever. J Pediatr 1970;77:824-829.Crossref 7. Steele RW, Young FS, Bass JW, et al: Oral antipyretic therapy: Evaluation of aspirin-acetaminophen combination. Am J Dis Child 1972;123:204-206.Crossref 8. Hunter J: Study of antipyretic therapy in current use. Arch Dis Child 1973;48:313-315.Crossref 9. Tarlin L, Landrigan P, Babineau R, et al: A comparison of the antipyretic effect of acetaminophen and aspirin: Another approach to poison prevention. Am J Dis Child 1972;124:880-882.Crossref 10. Windorfer A, Vogel C: Untersuchungen über Serumkonzentrationen und Temperaturverlauf nach einer neuen oral applizierbaren flüssigen Paracetamolzubereitung. Klin Paediatr 1976;188:430-434.
Archives of Internal Medicine – American Medical Association
Published: Feb 23, 1981