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Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosaInfection in Children With Cystic Fibrosis

Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas... ARTICLE JOURNAL CLUB Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis Miriam M. Treggiari, MD, PhD, MPH; George Retsch-Bogart, MD; Nicole Mayer-Hamblett, PhD; Umer Khan, MS; Michal Kulich, PhD; Richard Kronmal, PhD; Judy Williams, MPH†; Peter Hiatt, MD; Ronald L. Gibson, MD, PhD; Terry Spencer, MD; David Orenstein, MD; Barbara A. Chatfield, MD; Deborah K. Froh, MD; Jane L. Burns, MD; Margaret Rosenfeld, MD, MPH; Bonnie W. Ramsey, MD; for the Early Pseudomonas Infection Control (EPIC) Investigators Objective: To investigate the efficacy and safety of 4 an- nous antibiotics and proportion of P aeruginosa–positive tipseudomonal treatments in children with cystic fibrosis cultures. with recently acquired Pseudomonas aeruginosa infection. Results: The intention-to-treat analysis included 304 par- Design: Randomized controlled trial. ticipants. There was no interaction between treatments. There were no statistically significant differences in ex- Setting: Multicenter trial in the United States. acerbation rates between cycled and culture-based groups (hazard ratio, 0.95; 95% confidence interval [CI], 0.54- Participants: Three hundred four children with cystic 1.66) or ciprofloxacin and placebo (hazard ratio, 1.45; fibrosis aged 1 to 12 years within 6 months of P aerugi- 95% CI, 0.82-2.54). The odds http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosaInfection in Children With Cystic Fibrosis

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References (57)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2011.136
pmid
21893650
Publisher site
See Article on Publisher Site

Abstract

ARTICLE JOURNAL CLUB Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis Miriam M. Treggiari, MD, PhD, MPH; George Retsch-Bogart, MD; Nicole Mayer-Hamblett, PhD; Umer Khan, MS; Michal Kulich, PhD; Richard Kronmal, PhD; Judy Williams, MPH†; Peter Hiatt, MD; Ronald L. Gibson, MD, PhD; Terry Spencer, MD; David Orenstein, MD; Barbara A. Chatfield, MD; Deborah K. Froh, MD; Jane L. Burns, MD; Margaret Rosenfeld, MD, MPH; Bonnie W. Ramsey, MD; for the Early Pseudomonas Infection Control (EPIC) Investigators Objective: To investigate the efficacy and safety of 4 an- nous antibiotics and proportion of P aeruginosa–positive tipseudomonal treatments in children with cystic fibrosis cultures. with recently acquired Pseudomonas aeruginosa infection. Results: The intention-to-treat analysis included 304 par- Design: Randomized controlled trial. ticipants. There was no interaction between treatments. There were no statistically significant differences in ex- Setting: Multicenter trial in the United States. acerbation rates between cycled and culture-based groups (hazard ratio, 0.95; 95% confidence interval [CI], 0.54- Participants: Three hundred four children with cystic 1.66) or ciprofloxacin and placebo (hazard ratio, 1.45; fibrosis aged 1 to 12 years within 6 months of P aerugi- 95% CI, 0.82-2.54). The odds

Journal

JAMA Pediatrics – American Medical Association

Published: Sep 1, 2011

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