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COMPARATIVE EFFECTIVENESS OF PHENYLPROPANOLAMINE AND DEXTRO AMPHETAMINE ON WEIGHT REDUCTION

COMPARATIVE EFFECTIVENESS OF PHENYLPROPANOLAMINE AND DEXTRO AMPHETAMINE ON WEIGHT REDUCTION Abstract The anorexigenic effects of phenylpropanolamine and dextro amphetamine were compared in a study of 80 mentally deficient institutionalized patients, without dietary restrictions. One group received dextro amphetamine, two groups received phenylpropanolamine in dosages of 25 and 50 mg. thrice daily, and one group received a placebo. The average changes in weight for the four groups after two weeks were —4.6, —0.9, —0.8, and +0.3 lb. (—2.1, —0.41, —0.36, and +0.14 kg.) respectively. While the dextro amphetamine significantly reduced the voluntary intake of food in the first group, no significant effect was induced by the phenylpropanolamine even in double the recommended dosage. References 1. False and Misleading Advertising (Weight Reducing Remedies), 33rd Report by Committee on Government Operations of House of Representatives, 1958. 2. Fazekas, J. F.; Ehrmantraut, W. R.; and Kleh, J.: Study of Effectiveness of Certain Anorexigenic Agents , Am. J. M. Sc. 236:692-699 ( (Dec.) ) 1958.Crossref 3. Harris, S. C.: Clinically Useful Appetite Depressants , Ann. New York Acad. Sc. 63:121-131 ( (July 15) ) 1955.Crossref 4. Harris, S. C.; Ivy, A. C.; and Searle, L. M.: Mechanism of Amphetamine-Induced Loss of Weight: Consideration of Theory of Hunger and Appetite , J. A. M. A. 134:1468-1475 ( (Aug. 23) ) 1947.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

COMPARATIVE EFFECTIVENESS OF PHENYLPROPANOLAMINE AND DEXTRO AMPHETAMINE ON WEIGHT REDUCTION

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.03010090008002
Publisher site
See Article on Publisher Site

Abstract

Abstract The anorexigenic effects of phenylpropanolamine and dextro amphetamine were compared in a study of 80 mentally deficient institutionalized patients, without dietary restrictions. One group received dextro amphetamine, two groups received phenylpropanolamine in dosages of 25 and 50 mg. thrice daily, and one group received a placebo. The average changes in weight for the four groups after two weeks were —4.6, —0.9, —0.8, and +0.3 lb. (—2.1, —0.41, —0.36, and +0.14 kg.) respectively. While the dextro amphetamine significantly reduced the voluntary intake of food in the first group, no significant effect was induced by the phenylpropanolamine even in double the recommended dosage. References 1. False and Misleading Advertising (Weight Reducing Remedies), 33rd Report by Committee on Government Operations of House of Representatives, 1958. 2. Fazekas, J. F.; Ehrmantraut, W. R.; and Kleh, J.: Study of Effectiveness of Certain Anorexigenic Agents , Am. J. M. Sc. 236:692-699 ( (Dec.) ) 1958.Crossref 3. Harris, S. C.: Clinically Useful Appetite Depressants , Ann. New York Acad. Sc. 63:121-131 ( (July 15) ) 1955.Crossref 4. Harris, S. C.; Ivy, A. C.; and Searle, L. M.: Mechanism of Amphetamine-Induced Loss of Weight: Consideration of Theory of Hunger and Appetite , J. A. M. A. 134:1468-1475 ( (Aug. 23) ) 1947.Crossref

Journal

JAMAAmerican Medical Association

Published: Jun 27, 1959

References