ORIGINAL ARTICLE Common and Unique Therapeutic Mechanisms of Stimulant and Nonstimulant Treatments for Attention-Deficit/Hyperactivity Disorder Kurt P. Schulz, PhD; Jin Fan, PhD; Anne-Claude V. Be´dard, PhD; Suzanne M. Clerkin, PhD; Iliyan Ivanov, MD; Cheuk Y. Tang, PhD; Jeffrey M. Halperin, PhD; Jeffrey H. Newcorn, MD Context: Attention-deficit/hyperactivity disorder (ADHD) vestigator-completed ratings on the ADHD Rating Scale- is a highly prevalent and impairing psychiatric disorder IV-Parent Version. that affects both children and adults. There are Food and Drug Administration–approved stimulant and nonstimu- Results: Treatment with methylphenidate vs atomox- lant medications for treating ADHD; however, little is etine was associated with comparable improvements in both known about the mechanisms by which these different response inhibition on the go/no-go test and mean (SD) treatments exert their therapeutic effects. improvements in ratings of ADHD symptoms (55% [30%] vs 57% [25%]). Improvement in ADHD symptoms was as- Objective: To contrast changes in brain activation re- sociated with common reductions in bilateral motor cor- lated to symptomatic improvement with use of the stimu- tex activation for both treatments. Symptomatic improve- lant methylphenidate hydrochloride vs the nonstimu- ment was also differentially related to gains in task-related lant atomoxetine hydrochloride. activation for atomoxetine and reductions in activation
JAMA Psychiatry – American Medical Association
Published: Sep 1, 2012
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