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Commissural Connections and Symmetry of Degeneration in Alzheimer's Disease

Commissural Connections and Symmetry of Degeneration in Alzheimer's Disease Abstract To the Editor. —The observations of Moossy et al1 in a recent issue of the Archives on the distribution of the neuropathologic lesions of Alzheimer's disease are of interest, since there appear to be parallels between the symmetry (or lack thereof) of neurofibrillary tangles and the presence (or absence) of interhemispheric neuronal connections. These investigators reported that neuritic plaques are distributed symmetrically in the superior frontal and superior temporal gyri, prosubiculum, and entorhinal cortex, whereas neurofibrillary tangles are distributed symmetrically in neocortical areas but asymmetrically in the prosubiculum and entorhinal cortex.To the extent that these observations are accurate, it is noteworthy that macaques have prominent interhemispheric connections in neocortical association areas2 (S.D., D.L.R., G.W., V.H., unpublished observations, 1989), while such connections are lacking in all but the most rostral part of the hippocampal formation.3,4 Moreover, the entire extent of the prosubiculum lacks interhemispheric connections. Whereas neocortical References 1. Moossy J, Zubenko GS, Martinez AJ, Rao GR. Bilateral symmetry of morphologic lesions in Alzheimer's disease . Arch Neurol . 1988;45:251-254.Crossref 2. Karol EA, Pandya DN. The distribution of the corpus callosum in the rhesus monkey . Brain . 1971;94:471-486.Crossref 3. Demeter S, Rosene DL, Van Hoesen GW. Commissural pathways of the hippocampal formation, presubiculum and entorhinal and posterior parahippocampal cortices in the rhesus monkey: the structure and organization of the hippocampal commissures . J Comp Neurol . 1985;233:30-47.Crossref 4. Amaral DG, Insausti R, Cowan WM. The commissural connections of the monkey hippocampal formation . J Comp Neurol . 1984;224:307-336.Crossref 5. Van Hoesen GW, Hyman BT, Damasio AR. Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease . In: Swaab DF, Fliers E, Mirmiran M, Van Gool WA, Van Haaren F, eds. Progress in Brain Research . Amsterdam, the Netherlands: Elsevier Science Publishers; 1986:321-335. 6. Van Hoesen GW. The parahippocampal gyrus—new observations regarding its cortical connections in the monkey . Trends Neurosci . 1982;5:345-350.Crossref 7. de Lacoste MC, Kirkpatrick JB, Ross ED. Topography of the human corpus callosum . J Neuropathol Exp Neurol . 1985;44:578-591.Crossref 8. Schaltenbrand G, Spuler H, Wahren W. Electroanatomy of the corpus callosum radiation according to the facts of stereotactic stimulation in man . Z Neurol . 1970;198:79-92. 9. Demeter S, Rosene DL, Van Hoesen GW. The extent and organization of the primate hippocampal commissure . Neurology . 1983;33( (suppl 2) ):102. 10. Wilson CL, Babb TL, Engel J, et al: Lack of functional evidence for a human hippocampal commissure. Presented at the International Congress of EEG and Clinical Neurophysiology; 1985; London, England. 11. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation . Science . 1984;225:1168-1170.Crossref 12. Pearson RCA, Esiri MM, Hiorns RW, Wilcock GK, Powell TPS. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease . Proc Natl Acad Sci USA . 1985;82:4531-4534.Crossref 13. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices . J Neurosci . 1987;7:1799-1808. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Commissural Connections and Symmetry of Degeneration in Alzheimer's Disease

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1989.00520430017011
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —The observations of Moossy et al1 in a recent issue of the Archives on the distribution of the neuropathologic lesions of Alzheimer's disease are of interest, since there appear to be parallels between the symmetry (or lack thereof) of neurofibrillary tangles and the presence (or absence) of interhemispheric neuronal connections. These investigators reported that neuritic plaques are distributed symmetrically in the superior frontal and superior temporal gyri, prosubiculum, and entorhinal cortex, whereas neurofibrillary tangles are distributed symmetrically in neocortical areas but asymmetrically in the prosubiculum and entorhinal cortex.To the extent that these observations are accurate, it is noteworthy that macaques have prominent interhemispheric connections in neocortical association areas2 (S.D., D.L.R., G.W., V.H., unpublished observations, 1989), while such connections are lacking in all but the most rostral part of the hippocampal formation.3,4 Moreover, the entire extent of the prosubiculum lacks interhemispheric connections. Whereas neocortical References 1. Moossy J, Zubenko GS, Martinez AJ, Rao GR. Bilateral symmetry of morphologic lesions in Alzheimer's disease . Arch Neurol . 1988;45:251-254.Crossref 2. Karol EA, Pandya DN. The distribution of the corpus callosum in the rhesus monkey . Brain . 1971;94:471-486.Crossref 3. Demeter S, Rosene DL, Van Hoesen GW. Commissural pathways of the hippocampal formation, presubiculum and entorhinal and posterior parahippocampal cortices in the rhesus monkey: the structure and organization of the hippocampal commissures . J Comp Neurol . 1985;233:30-47.Crossref 4. Amaral DG, Insausti R, Cowan WM. The commissural connections of the monkey hippocampal formation . J Comp Neurol . 1984;224:307-336.Crossref 5. Van Hoesen GW, Hyman BT, Damasio AR. Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease . In: Swaab DF, Fliers E, Mirmiran M, Van Gool WA, Van Haaren F, eds. Progress in Brain Research . Amsterdam, the Netherlands: Elsevier Science Publishers; 1986:321-335. 6. Van Hoesen GW. The parahippocampal gyrus—new observations regarding its cortical connections in the monkey . Trends Neurosci . 1982;5:345-350.Crossref 7. de Lacoste MC, Kirkpatrick JB, Ross ED. Topography of the human corpus callosum . J Neuropathol Exp Neurol . 1985;44:578-591.Crossref 8. Schaltenbrand G, Spuler H, Wahren W. Electroanatomy of the corpus callosum radiation according to the facts of stereotactic stimulation in man . Z Neurol . 1970;198:79-92. 9. Demeter S, Rosene DL, Van Hoesen GW. The extent and organization of the primate hippocampal commissure . Neurology . 1983;33( (suppl 2) ):102. 10. Wilson CL, Babb TL, Engel J, et al: Lack of functional evidence for a human hippocampal commissure. Presented at the International Congress of EEG and Clinical Neurophysiology; 1985; London, England. 11. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation . Science . 1984;225:1168-1170.Crossref 12. Pearson RCA, Esiri MM, Hiorns RW, Wilcock GK, Powell TPS. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease . Proc Natl Acad Sci USA . 1985;82:4531-4534.Crossref 13. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices . J Neurosci . 1987;7:1799-1808.

Journal

Archives of NeurologyAmerican Medical Association

Published: Jul 1, 1989

References