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Combined Vitamin D Parathyroid Defect in Thalassemia Major

Combined Vitamin D Parathyroid Defect in Thalassemia Major Abstract A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively. As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy. (Arch Intern Med 1982;142:831-832) References 1. Johnston FE, Krogman WM: Patterns of growth in children with thalassemia major. Ann NY Acad Sci 1974;232:667-679. 2. Canale VC, Steinherz P, New M, et al: Endocrine function in thalassemia major. Ann NY Acad Sci 1974;232:333-345.Crossref 3. Erlandson ME, Brilliant R, Smith CH: Comparison of 66 patients with thalassemia major and 13 patients with thalassemia intermedia: Including evaluations of growth, development, maturation and prognosis. Ann NY Acad Sci 1974;232:727-735. 4. Newns GH: Endocrinopathies in thalassemia major. Acta Paediatr Scand 1973;62:91. 5. Oberklaid F, Seshadri R: Hypoparathyroidism and other endocrine dysfunction complicating thalassemia major. Med J Aust 1975;1:304-306. 6. Flynn DM, Fairney A, Jackson D, et al: Hormonal changes in thalassemia major. Arch Dis Child 1976;51:828-836.Crossref 7. Lassman MN, O'Brien RT, Pearson HA, et al: Endocrine evaluation in thalassemia major. Ann NY Acad Sci 1974;232:226-237.Crossref 8. Mautalen CA, Kvicala R, Perriard D, et al: Case report: Hypoparathyroidism and iron storage disease: Treatment with 25-hydroxy-vitamin D3. Am J Med Sci 1978;276:363-368.Crossref 9. Kleerekoper M, Ingham JP, McCarthy SW, et al: Parathyroid hormone assay in primary hyperparathyroidism. Clin Chem 1974;20:369-375. 10. Haddad J: Competitive protein binding radioassay for 25-hydroxy-cholecalciferol. J Clin Endocrinol Metab 1971;33:992-995.Crossref 11. Gertner JM, Broadus AE, Anast CS, et al: Impaired parathyroid response to induced hypocalcemia in thalassemia major. J Pediatr 1979; 95:210-213.Crossref 12. Tsitoura S, Amarilio N, Lapatsan P, et al: Serum 25-hydroxyvitamin D levels in thalassemia. Arch Dis Child 1978;53:347-348.Crossref 13. Liakakos D, Vlachos P, Anoussakis C, et al: Calcium metabolism in children suffering from homozygous β-thalassemia after oral administration of "Ca. Nuklearmedizin 1976;15:77-79. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Combined Vitamin D Parathyroid Defect in Thalassemia Major

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340170191029
Publisher site
See Article on Publisher Site

Abstract

Abstract A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively. As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy. (Arch Intern Med 1982;142:831-832) References 1. Johnston FE, Krogman WM: Patterns of growth in children with thalassemia major. Ann NY Acad Sci 1974;232:667-679. 2. Canale VC, Steinherz P, New M, et al: Endocrine function in thalassemia major. Ann NY Acad Sci 1974;232:333-345.Crossref 3. Erlandson ME, Brilliant R, Smith CH: Comparison of 66 patients with thalassemia major and 13 patients with thalassemia intermedia: Including evaluations of growth, development, maturation and prognosis. Ann NY Acad Sci 1974;232:727-735. 4. Newns GH: Endocrinopathies in thalassemia major. Acta Paediatr Scand 1973;62:91. 5. Oberklaid F, Seshadri R: Hypoparathyroidism and other endocrine dysfunction complicating thalassemia major. Med J Aust 1975;1:304-306. 6. Flynn DM, Fairney A, Jackson D, et al: Hormonal changes in thalassemia major. Arch Dis Child 1976;51:828-836.Crossref 7. Lassman MN, O'Brien RT, Pearson HA, et al: Endocrine evaluation in thalassemia major. Ann NY Acad Sci 1974;232:226-237.Crossref 8. Mautalen CA, Kvicala R, Perriard D, et al: Case report: Hypoparathyroidism and iron storage disease: Treatment with 25-hydroxy-vitamin D3. Am J Med Sci 1978;276:363-368.Crossref 9. Kleerekoper M, Ingham JP, McCarthy SW, et al: Parathyroid hormone assay in primary hyperparathyroidism. Clin Chem 1974;20:369-375. 10. Haddad J: Competitive protein binding radioassay for 25-hydroxy-cholecalciferol. J Clin Endocrinol Metab 1971;33:992-995.Crossref 11. Gertner JM, Broadus AE, Anast CS, et al: Impaired parathyroid response to induced hypocalcemia in thalassemia major. J Pediatr 1979; 95:210-213.Crossref 12. Tsitoura S, Amarilio N, Lapatsan P, et al: Serum 25-hydroxyvitamin D levels in thalassemia. Arch Dis Child 1978;53:347-348.Crossref 13. Liakakos D, Vlachos P, Anoussakis C, et al: Calcium metabolism in children suffering from homozygous β-thalassemia after oral administration of "Ca. Nuklearmedizin 1976;15:77-79.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1982

References