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Abstract The clinical manifestations and pathologic observations in tabes dorsalis are too well known to be discussed in this presentation. A combined lesion of the posterior columns and pyramidal tracts, giving the cord the appearance of subacute combined degeneration, although described, is less frequently observed. The pathologic lesions in a number of cases described in the literature as instances of tabes in combination with involvement of the lateral tracts were due to syphilitic or arteriosclerotic vascular disease, to inflammatory or other diseases of the spinal cord or to descending degeneration from lesions above the spinal cord. A careful survey of the clinical features shows that many are not clearcut cases of tabes. The question arises whether the pathologic changes in the pyramidal pathways can be attributed to the same process that causes the destruction of the posterior columns. In five of a series of fifteen cases of tabes dorsalis in which References 1. Westphal, C.: Ueber strangförmige Degeneration der Hinterstränge mit gleichzeitiger fleckweiser Degeneration des Rückenmarks , Arch. f. Psychiat. 9: 389, 1879.Crossref 2. Prevost, J. L.: Ataxie locomotrice: Sclérose des cordons postérieurs, compliquée d'une sclérose symétrique des cordons latéraux , Arch. de physiol. norm. et path. 4:764, 1877. 3. Pierret, M.: Note sur la sclérose des cordons postérieurs dans l'ataxie locomotrice progressive , Arch de physiol, norm. et path. 75:364, 1871. 4. Schmaus, H.: Zur pathologischen Anatomie der Seitenstrangerkrankung bei Tabes dorsalis , Deutsches Arch. f. klin. Med. 46:116, 1889-1890. 5. Raymond, F.: Contribution à l'anatomie pathologique tu tabes dorsalis: Sur la topographie des lésions spinales du tabes au début , Rev. de méd. 11:1, 1891. 6. Déjerine, J., and Thomas, A.: Maladie de la moelle épinière , Paris, J.-B. Baillière & fils, 1909. 7. Kattwinkel, W.: Ueber aquirierte combinierte Strangsclerosen , Deutsches Arch. f. klin. Med. 75:37, 1902. 8. Keschner, M., and Davison, C.: Myelitic and Myelopathic Lesions: III. Arteriosclerotic and Arteritic Myelopathy , Arch. Neurol. & Psychiat. 29:702 ( (April) ) 1933. 9. Marie, P., and Crouzon, O.: Étude clinique de la forme tabétique des scléroses combinées , Rev. neurol. 11:326, 1903. 10. Bramwell, B.: Analysis of One Hundred and Fifty-Five Cases of Tabes , Brain 25:19, 1902. 11. Marie, P., and Guillain, G.: Les lésions du système lymphatique postérieur de la moelle sont l'origine du processus anatomo-pathologique du tabes , Rev. neurol. 11:49, 1903. 12. Obersteiner, H., and Redlich, E.: Ueber das Wesen und Pathogenese der tabischen Hinterstranges-Degeneration , Arb. a. d. Inst. f. Anat. u. Physiol. d. Centralnervensyst. an d. Wien. Univ. 2:158, 1894 13. 3:192, 1895. 14. Nageotte, I.: Pathogénie du tabes dorsal , Paris, G. Naud, 1904. 15. Hassin, G. B.: Tabes Dorsalis , Arch. Neurol. & Psychiat. 21:311 ( (Feb.) ) 1929. 16. Strümpell, A.: Die pathologische Anatomie der Tabes , Arch. f. Psychiat. 12:723, 1882. 17. Spielmeyer, W.: Pathogenese der Tabes und Unterschiede der Degenerationsvorgänge im peripheren und zentralen Nervensystem , Ztschr. f. d. ges. Neurol. u. Psychiat. 91:627, 1924.
Archives of Neurology & Psychiatry – American Medical Association
Published: Jul 1, 1937
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