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COMBINED BACITRACIN-NEOMYCIN OINTMENT IN TREATMENT OF PYOGENIC INFECTIONS OF THE SKIN

COMBINED BACITRACIN-NEOMYCIN OINTMENT IN TREATMENT OF PYOGENIC INFECTIONS OF THE SKIN Abstract Bacitracin is quite effective locally against a wide variety of Gram-positive micro-organisms, including Staphylococcus, beta hemolytic Streptococcus, Pneumococcus, Clostridium welchii, some of the actinomycetes, Treponema pallidum, and others. Its nephrotoxic properties and irritative local effects when injected intramuscularly have precluded its use except as a topical application, where it has been used with great success. Neomycin is very effective locally against Gram-negative and Gram-positive organisms. However, the hepatotoxic and ototoxic properties of neomycin preclude its systemic adminstration. Some patients with hemolytic Streptococcus and B. pyocyaneus (Pseudomonas aeruginosa) infections, in a series treated by Kile, did not respond satisfactorily to neomycin ointment. Since both bacitracin and neomycin are not used systemically and since the two together are effective against all Gram-negative and Gram-positive organisms, a combination of the two in a petrolatum ointment base containing 500 units of bacitracin and 5 mg. of neomycin sulfate per gram of base* was References 1. Rhoads, P. S.: Practical Therapeutics: Antibiotics—Uses and Abuses , GP 5:67-78 ( (Feb.) ) 1952. 2. Livingood, C. S.; Nilasena, S.; King, W. C.; Stevenson, R. A., and Mullins, F. J.: Pyogenic Infections Treated with Neomycin , J. A. M. A. 148:334-339 ( (Feb. 2) ) 1952.Crossref 3. Kile, R. L.; Rockwell, E. M.; Schwartz, J.: Use of Neomycin in Dermatology , J. A. M. A. 148:339-343 ( (Feb. 2) ) 1952.Crossref 4. Bacimycin ointment. Walker Laboratories, Inc., Mt. Vernon, N. Y., supplied the material used in these studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

COMBINED BACITRACIN-NEOMYCIN OINTMENT IN TREATMENT OF PYOGENIC INFECTIONS OF THE SKIN

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1954.01540150112012
Publisher site
See Article on Publisher Site

Abstract

Abstract Bacitracin is quite effective locally against a wide variety of Gram-positive micro-organisms, including Staphylococcus, beta hemolytic Streptococcus, Pneumococcus, Clostridium welchii, some of the actinomycetes, Treponema pallidum, and others. Its nephrotoxic properties and irritative local effects when injected intramuscularly have precluded its use except as a topical application, where it has been used with great success. Neomycin is very effective locally against Gram-negative and Gram-positive organisms. However, the hepatotoxic and ototoxic properties of neomycin preclude its systemic adminstration. Some patients with hemolytic Streptococcus and B. pyocyaneus (Pseudomonas aeruginosa) infections, in a series treated by Kile, did not respond satisfactorily to neomycin ointment. Since both bacitracin and neomycin are not used systemically and since the two together are effective against all Gram-negative and Gram-positive organisms, a combination of the two in a petrolatum ointment base containing 500 units of bacitracin and 5 mg. of neomycin sulfate per gram of base* was References 1. Rhoads, P. S.: Practical Therapeutics: Antibiotics—Uses and Abuses , GP 5:67-78 ( (Feb.) ) 1952. 2. Livingood, C. S.; Nilasena, S.; King, W. C.; Stevenson, R. A., and Mullins, F. J.: Pyogenic Infections Treated with Neomycin , J. A. M. A. 148:334-339 ( (Feb. 2) ) 1952.Crossref 3. Kile, R. L.; Rockwell, E. M.; Schwartz, J.: Use of Neomycin in Dermatology , J. A. M. A. 148:339-343 ( (Feb. 2) ) 1952.Crossref 4. Bacimycin ointment. Walker Laboratories, Inc., Mt. Vernon, N. Y., supplied the material used in these studies.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Mar 1, 1954

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