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Coloboma of Optic Nerve Associated With Serous Maculopathy: A Clinicopathologic Correlative Study

Coloboma of Optic Nerve Associated With Serous Maculopathy: A Clinicopathologic Correlative Study Abstract • A rhesus monkey with a congenital coloboma of the optic nerve head associated with serous macular detachment underwent intravenous (IV), intrathecal, and retrobulbar fluorescein angiography. No fluorescein leaked beneath the serous detachment after IV or intrathecal injection, although the retrobulbar injection caused a bolus to extravasate from the margin of the optic nerve coloboma, drifting toward the macular region temporally. Histopathologically, glial tissue replaced optic nerve axonal bundles in the temporal coloboma. The intermediary tissue of Kuhnt was disrupted, and fluid from the retrobulbar space diffused into the sub-retinal space temporally, where a localized retinal detachment extended from the optic nerve to the macula. Subretinal fluid in the macula associated with optic nerve coloboma might derive from (1) fluid perfusing into the retrobulbar space from surrounding orbital tissue, (2) peripapillary choriocapillaris, or (3) CSF. References 1. Sugar HS: Congenital pit in the optic disc . Am J Ophthalmol 1967;63:298-307. 2. Brockhurst RJ: Optic pit and posterior retinal detachment . Trans Am Ophthalmol Soc 1975; 73:265-291. 3. Brown GC, Shield JA, Goldberg RE: Congenital pit of the optic nervehead: II. Clinical studies in humans . Ophthalmology 1980;87:51-65.Crossref 4. Gass JD: Serous detachment of the macula secondary to congenital pit of the optic nervehead . Am J Ophthalmol 1969;67:821-841. 5. Sugar HS: An explanation for the acquired macular pathology associated with congenital pit of the optic disc . Am J Ophthalmol 1964;57:833-835. 6. Johnson AW, Smith JL: Macular changes with pit of optic disc . Am J Ophthalmol 1963; 55:1070-1072. 7. Henkind P: Crater-like hole of the optic nerve . Am J Ophthalmol 1963;55:613-615. 8. Regenbogen L, Lazar M: Macular and juxtapapillar serous retinal detachment associated with pit of optic disc . Ophthalmology 1964; 148:247-251.Crossref 9. Mustonen E, Varonen T: Congenital pit of the optic nervehead associated with serous detachment of the macula . Acta Ophthalmol 1972;50:689-698.Crossref 10. Ferry AP: Macular detachment associated with congenital pit optic nervehead . Arch Ophthalmol 1963;70:346-357.Crossref 11. Petersen HP: Pit or crater-like holes in the optic disc . Acta Ophthalmol 1958;36:435-443.Crossref 12. Payne BF: Coloboma of the optic nerve in the human embryo . Am J Ophthalmol 1941; 24:395-402. 13. Calhoun FP: Bilateral coloboma of the optic nerve . Arch Ophthalmol 1930;3:71-79.Crossref 14. Brown GC, Shields JA, Patty BE, et al: Congenital pits of the optic nerve head: I. Experimental studies in collie dogs . Arch Ophthalmol 1979;97:1341-1344.Crossref 15. Wessing A: Fluorescein Angiography of the Retina , Von Hoorden GK (trans). St Louis, CV Mosby Co, 1969, p 179. 16. Miyake K: Fluorescein fundusgraphy by retrobulbar injection . Acta Soc Ophthalmol Jpn 1974;78:1456. 17. Miyake K, Miura H, Sakamura S, et al: Fluorescein fundusgraphy by retrobulbar injection . Acta Soc Ophthalmol Jpn 1975;79:969-975. 18. Hayreh SS: Optic disc edema in raised intracranial pressure: V. Pathogenesis . Arch Ophthalmol 1977;95:1553-1565.Crossref 19. Bill A: Drainage of intraocular fluid in the blood-retinal barriers , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Press, 1979, pp 179-193. 20. Friedenwald JS, Chan E: Pathogenesis of retinitis pigmentosa . Arch Ophthalmol 1932; 8:173-181.Crossref 21. Peyman GA, Bok D: Peroxidase diffuse process in the normal and laser coagulated primate retina . Invest Ophthalmol 1972;11:35-45. 22. Tso MOM, Shih CY, McLean IW: Is there a blood-retinal barrier at the optic nerve head? Arch Ophthalmol 1975;93:815-825.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Coloboma of Optic Nerve Associated With Serous Maculopathy: A Clinicopathologic Correlative Study

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040031341023
Publisher site
See Article on Publisher Site

Abstract

Abstract • A rhesus monkey with a congenital coloboma of the optic nerve head associated with serous macular detachment underwent intravenous (IV), intrathecal, and retrobulbar fluorescein angiography. No fluorescein leaked beneath the serous detachment after IV or intrathecal injection, although the retrobulbar injection caused a bolus to extravasate from the margin of the optic nerve coloboma, drifting toward the macular region temporally. Histopathologically, glial tissue replaced optic nerve axonal bundles in the temporal coloboma. The intermediary tissue of Kuhnt was disrupted, and fluid from the retrobulbar space diffused into the sub-retinal space temporally, where a localized retinal detachment extended from the optic nerve to the macula. Subretinal fluid in the macula associated with optic nerve coloboma might derive from (1) fluid perfusing into the retrobulbar space from surrounding orbital tissue, (2) peripapillary choriocapillaris, or (3) CSF. References 1. Sugar HS: Congenital pit in the optic disc . Am J Ophthalmol 1967;63:298-307. 2. Brockhurst RJ: Optic pit and posterior retinal detachment . Trans Am Ophthalmol Soc 1975; 73:265-291. 3. Brown GC, Shield JA, Goldberg RE: Congenital pit of the optic nervehead: II. Clinical studies in humans . Ophthalmology 1980;87:51-65.Crossref 4. Gass JD: Serous detachment of the macula secondary to congenital pit of the optic nervehead . Am J Ophthalmol 1969;67:821-841. 5. Sugar HS: An explanation for the acquired macular pathology associated with congenital pit of the optic disc . Am J Ophthalmol 1964;57:833-835. 6. Johnson AW, Smith JL: Macular changes with pit of optic disc . Am J Ophthalmol 1963; 55:1070-1072. 7. Henkind P: Crater-like hole of the optic nerve . Am J Ophthalmol 1963;55:613-615. 8. Regenbogen L, Lazar M: Macular and juxtapapillar serous retinal detachment associated with pit of optic disc . Ophthalmology 1964; 148:247-251.Crossref 9. Mustonen E, Varonen T: Congenital pit of the optic nervehead associated with serous detachment of the macula . Acta Ophthalmol 1972;50:689-698.Crossref 10. Ferry AP: Macular detachment associated with congenital pit optic nervehead . Arch Ophthalmol 1963;70:346-357.Crossref 11. Petersen HP: Pit or crater-like holes in the optic disc . Acta Ophthalmol 1958;36:435-443.Crossref 12. Payne BF: Coloboma of the optic nerve in the human embryo . Am J Ophthalmol 1941; 24:395-402. 13. Calhoun FP: Bilateral coloboma of the optic nerve . Arch Ophthalmol 1930;3:71-79.Crossref 14. Brown GC, Shields JA, Patty BE, et al: Congenital pits of the optic nerve head: I. Experimental studies in collie dogs . Arch Ophthalmol 1979;97:1341-1344.Crossref 15. Wessing A: Fluorescein Angiography of the Retina , Von Hoorden GK (trans). St Louis, CV Mosby Co, 1969, p 179. 16. Miyake K: Fluorescein fundusgraphy by retrobulbar injection . Acta Soc Ophthalmol Jpn 1974;78:1456. 17. Miyake K, Miura H, Sakamura S, et al: Fluorescein fundusgraphy by retrobulbar injection . Acta Soc Ophthalmol Jpn 1975;79:969-975. 18. Hayreh SS: Optic disc edema in raised intracranial pressure: V. Pathogenesis . Arch Ophthalmol 1977;95:1553-1565.Crossref 19. Bill A: Drainage of intraocular fluid in the blood-retinal barriers , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Press, 1979, pp 179-193. 20. Friedenwald JS, Chan E: Pathogenesis of retinitis pigmentosa . Arch Ophthalmol 1932; 8:173-181.Crossref 21. Peyman GA, Bok D: Peroxidase diffuse process in the normal and laser coagulated primate retina . Invest Ophthalmol 1972;11:35-45. 22. Tso MOM, Shih CY, McLean IW: Is there a blood-retinal barrier at the optic nerve head? Arch Ophthalmol 1975;93:815-825.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1984

References