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Colchicine Therapy for Psoriasis

Colchicine Therapy for Psoriasis Abstract To the Editor.— We were concerned to read the article on topical application of colchicine for psoriasis by Kaidbey et al.1 In addition to side-effects in humans reported by Malkinson and Lynfield,2 among which were diarrhea, amenorrhea, and possibly hematological changes following systemic use of colchicine and irritant effects after local use of the substance, we want to report our observations on the effects of topical application of colchicine on guinea pig skin.Application of 0.1% or 1% colchicine in emulsifying ointment to about 10% of the total body surface area of the guinea pig for five days produces almost complete necrosis in the areas treated (Fig 1) and inhibition of mitosis in untreated regions of the animal skin. It also causes suppression of formation of the stratum granulosum (Fig 2, left). The effect of emulsifying ointment (Fig 2, right) on guinea pig skin is shown for comparison References 1. Kaidbey KH, Petrozzi JW, Kligman AM: Topical colchicine therapy for recalcitrant psoriasis . Arch Dermatol 111:33-36, 1975.Crossref 2. Malkinson FD, Lynfield YL: Colchicine alopecia . Arch Dermatol 33:371-384, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Colchicine Therapy for Psoriasis

Archives of Dermatology , Volume 112 (4) – Apr 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630280074028
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— We were concerned to read the article on topical application of colchicine for psoriasis by Kaidbey et al.1 In addition to side-effects in humans reported by Malkinson and Lynfield,2 among which were diarrhea, amenorrhea, and possibly hematological changes following systemic use of colchicine and irritant effects after local use of the substance, we want to report our observations on the effects of topical application of colchicine on guinea pig skin.Application of 0.1% or 1% colchicine in emulsifying ointment to about 10% of the total body surface area of the guinea pig for five days produces almost complete necrosis in the areas treated (Fig 1) and inhibition of mitosis in untreated regions of the animal skin. It also causes suppression of formation of the stratum granulosum (Fig 2, left). The effect of emulsifying ointment (Fig 2, right) on guinea pig skin is shown for comparison References 1. Kaidbey KH, Petrozzi JW, Kligman AM: Topical colchicine therapy for recalcitrant psoriasis . Arch Dermatol 111:33-36, 1975.Crossref 2. Malkinson FD, Lynfield YL: Colchicine alopecia . Arch Dermatol 33:371-384, 1959.

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1976

References