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Coccidioidomycosis and Neck Mass 'Single Lesion' Disseminated Disease

Coccidioidomycosis and Neck Mass 'Single Lesion' Disseminated Disease Abstract • Coccidioidomycosis is a fungal disease endemic to parts of the southwestern United States, parts of Mexico, and parts of Central and South America. Headache and sore throat may be primary manifestations of the disease in its nondisseminated form, and laryngeal involvement has been reported. Except for the very rare appearance of supraclavicular nodes, neck nodes have not been previously reported. In two patients, a neck mass was the only manifestation of disease. In the first patient, excision was curative; in the second, treatment with ketoconazole resulted in cure. These two patients represent an example of "single lesion" disseminated disease. Coccidioidomycosis should be added to the list of causes of neck masses. (Arch Otolaryngol Head Neck Surg 1987;113:553-555) References 1. Drutz DJ, Catanzaro A: I. Coccidioidomycosis . Am Rev Respir Dis 1978;117:559-585. 2. Ajello L: Coccidioidomycosis and histoplasmosis: A review of their epidemiology and geographical distribution . Mycopathologia 1971; 45:221-230. 3. Coburn JW: Scalene lymph node involvement in primary and disseminated coccidioidomycosis: Evidence of extrapulmonary spread in primary infection . Ann Intern Med 1962;56:911-924.Crossref 4. Drutz DJ, Catanzaro A: II. Coccidioidomycosis . Am Rev Respir Dis 1978;117:727-771. 5. Plat MA: Laryngeal coccidioidomycosis . JAMA 1977;237:1234-1235.Crossref 6. Ward PH, Berci G, Morledge D, et al: Coccidioidomycosis of the larynx in infants and adults . Ann Otol Rhinol Laryngol 1977;86:655-660. 7. Singh H, Yast CJ, Gladney JH: Coccidioidomycosis with endolaryngeal involvement . Arch Otolaryngol Head Neck Surg 1956;63:244-247.Crossref 8. Mumma CS: Coccidioidomycosis of the epiglottis . Arch Otolaryngol Head Neck Surg 1953; 58:306-309.Crossref 9. Swatek FE: Ecology of Coccidioides immitis . Mycopathologia 1970;41:3-12. 10. Smith CE, Beard RR, Whiting EG, et al: Varieties of coccidioidal infection in relation to the epidemiology and control of the diseases . Am J Public Health 1946;36:1394-1402.Crossref 11. Galgiani JN, Payne CM, Jones JF: Human polymorphonuclear leukocyte inhibition of incorporation of chitin precursors into mycelia of Coccidioides immitis . J Infect Dis 1984;149:404-412.Crossref 12. Alkin D, Evans BH: Coccidioidomycosis , in Steele JD (ed): Treatment of Mycotic and Parasitic Diseases of the Chest . Springfield, Ill, Charles C Thomas Publishers, 1964, pp 55-119. 13. Smith CE: Diagnosis of pulmonary coccidioidal infections . Calif Med 1951;75:385-391. 14. Huppert M, Krasnow I, Vukovich KR, et al: Comparison of coccidioidin and spherulin in complement fixation tests for coccidioidomycosis . J Clin Microbiol 1977;6:33-41. 15. Smith CE, Saito MT, Simons SA: Pattern of 39 500 serologic tests in coccidioidomycosis . JAMA 1956;160:546-552.Crossref 16. Stadalnick RC, Goldstein E, Hoeprich PD, et al: Diagnostic value of gallium and bone scans in evaluation of extrapulmonary coccidioidal lesions . Am Rev Respir Dis 1980;121:673-676. 17. Pappagianis D: Coccidioidomycosis , in Samter M (ed): Immunological Disease . Boston, Little Brown & Co Inc, 1978, pp 681-691. 18. Hoeprich PD, Huston AC: Susceptibility of Coccidioides immitis, Candida albicans, and Cryptococcus neoformans to amphotericin B, flucytosine and clotrimazole . J Infect Dis 1975; 132:133-141.Crossref 19. Lopez Berestein G, Fainstein V, Hopfer R, et al: Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study . J Infect Dis 1985;151:704-710. 20. Sarosi, GA: Management of fungal diseases . Am Rev Respir Dis 1983;127:250-253. 21. Schaffner A, Frick PG: The effect of ketoconazole on amphotericin B in a model of disseminated aspergillosis . J Infect Dis 1985;151:902-910.Crossref 22. Brajtburg J, Kobayashi D, Medoff G, et al: Antifungal action of amphotericin B in combination with other polyene or imidazole antibiotics . J Infect Dis 1982;146:138-146.Crossref 23. Alvarez S, McCabe WR: Extrapulmonary tuberculosis revisited: A review of experience at Boston City and other hospitals . Medicine 1984;63:25-55.Crossref 24. Kent DC: Tuberculous lymphadenitis: Not a localized disease process . Am J Med Sci 1967;254:866-873.Crossref 25. Saitz EW: Cervical lymphadenitis caused by atypical mycobacteria Pediatr Clin North Am 1981;28:823-839. 26. Saitz EW: Cervical lymphadenitis caused by atypical mycobacteria . Pediatr Clin North Am 1981;28:823-839. 27. Stulberg CS, Zuelzer WW, Page RH, et al: Cytomegalovirus infections with reference to isolations from lymph nodes and blood . Proc Soc Exp Biol Med 1966;123:976-982.Crossref 28. Ginsburg CM: Cat-scratch adenitis . Pediatr Infect Dis 1984;3:437-439.Crossref 29. Rafaty FM: Cervical adenopathy secondary to toxoplasmosis . Arch Otolaryngol Head Neck Surg 1977;103:547-549.Crossref 30. Dudley JP: Epstein-Barr virus and a unilateral neck mass . Arch Otolaryngol Head Neck Surg 1982;108:253-254.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Coccidioidomycosis and Neck Mass 'Single Lesion' Disseminated Disease

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1987.01860050099025
Publisher site
See Article on Publisher Site

Abstract

Abstract • Coccidioidomycosis is a fungal disease endemic to parts of the southwestern United States, parts of Mexico, and parts of Central and South America. Headache and sore throat may be primary manifestations of the disease in its nondisseminated form, and laryngeal involvement has been reported. Except for the very rare appearance of supraclavicular nodes, neck nodes have not been previously reported. In two patients, a neck mass was the only manifestation of disease. In the first patient, excision was curative; in the second, treatment with ketoconazole resulted in cure. These two patients represent an example of "single lesion" disseminated disease. Coccidioidomycosis should be added to the list of causes of neck masses. (Arch Otolaryngol Head Neck Surg 1987;113:553-555) References 1. Drutz DJ, Catanzaro A: I. Coccidioidomycosis . Am Rev Respir Dis 1978;117:559-585. 2. Ajello L: Coccidioidomycosis and histoplasmosis: A review of their epidemiology and geographical distribution . Mycopathologia 1971; 45:221-230. 3. Coburn JW: Scalene lymph node involvement in primary and disseminated coccidioidomycosis: Evidence of extrapulmonary spread in primary infection . Ann Intern Med 1962;56:911-924.Crossref 4. Drutz DJ, Catanzaro A: II. Coccidioidomycosis . Am Rev Respir Dis 1978;117:727-771. 5. Plat MA: Laryngeal coccidioidomycosis . JAMA 1977;237:1234-1235.Crossref 6. Ward PH, Berci G, Morledge D, et al: Coccidioidomycosis of the larynx in infants and adults . Ann Otol Rhinol Laryngol 1977;86:655-660. 7. Singh H, Yast CJ, Gladney JH: Coccidioidomycosis with endolaryngeal involvement . Arch Otolaryngol Head Neck Surg 1956;63:244-247.Crossref 8. Mumma CS: Coccidioidomycosis of the epiglottis . Arch Otolaryngol Head Neck Surg 1953; 58:306-309.Crossref 9. Swatek FE: Ecology of Coccidioides immitis . Mycopathologia 1970;41:3-12. 10. Smith CE, Beard RR, Whiting EG, et al: Varieties of coccidioidal infection in relation to the epidemiology and control of the diseases . Am J Public Health 1946;36:1394-1402.Crossref 11. Galgiani JN, Payne CM, Jones JF: Human polymorphonuclear leukocyte inhibition of incorporation of chitin precursors into mycelia of Coccidioides immitis . J Infect Dis 1984;149:404-412.Crossref 12. Alkin D, Evans BH: Coccidioidomycosis , in Steele JD (ed): Treatment of Mycotic and Parasitic Diseases of the Chest . Springfield, Ill, Charles C Thomas Publishers, 1964, pp 55-119. 13. Smith CE: Diagnosis of pulmonary coccidioidal infections . Calif Med 1951;75:385-391. 14. Huppert M, Krasnow I, Vukovich KR, et al: Comparison of coccidioidin and spherulin in complement fixation tests for coccidioidomycosis . J Clin Microbiol 1977;6:33-41. 15. Smith CE, Saito MT, Simons SA: Pattern of 39 500 serologic tests in coccidioidomycosis . JAMA 1956;160:546-552.Crossref 16. Stadalnick RC, Goldstein E, Hoeprich PD, et al: Diagnostic value of gallium and bone scans in evaluation of extrapulmonary coccidioidal lesions . Am Rev Respir Dis 1980;121:673-676. 17. Pappagianis D: Coccidioidomycosis , in Samter M (ed): Immunological Disease . Boston, Little Brown & Co Inc, 1978, pp 681-691. 18. Hoeprich PD, Huston AC: Susceptibility of Coccidioides immitis, Candida albicans, and Cryptococcus neoformans to amphotericin B, flucytosine and clotrimazole . J Infect Dis 1975; 132:133-141.Crossref 19. Lopez Berestein G, Fainstein V, Hopfer R, et al: Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study . J Infect Dis 1985;151:704-710. 20. Sarosi, GA: Management of fungal diseases . Am Rev Respir Dis 1983;127:250-253. 21. Schaffner A, Frick PG: The effect of ketoconazole on amphotericin B in a model of disseminated aspergillosis . J Infect Dis 1985;151:902-910.Crossref 22. Brajtburg J, Kobayashi D, Medoff G, et al: Antifungal action of amphotericin B in combination with other polyene or imidazole antibiotics . J Infect Dis 1982;146:138-146.Crossref 23. Alvarez S, McCabe WR: Extrapulmonary tuberculosis revisited: A review of experience at Boston City and other hospitals . Medicine 1984;63:25-55.Crossref 24. Kent DC: Tuberculous lymphadenitis: Not a localized disease process . Am J Med Sci 1967;254:866-873.Crossref 25. Saitz EW: Cervical lymphadenitis caused by atypical mycobacteria Pediatr Clin North Am 1981;28:823-839. 26. Saitz EW: Cervical lymphadenitis caused by atypical mycobacteria . Pediatr Clin North Am 1981;28:823-839. 27. Stulberg CS, Zuelzer WW, Page RH, et al: Cytomegalovirus infections with reference to isolations from lymph nodes and blood . Proc Soc Exp Biol Med 1966;123:976-982.Crossref 28. Ginsburg CM: Cat-scratch adenitis . Pediatr Infect Dis 1984;3:437-439.Crossref 29. Rafaty FM: Cervical adenopathy secondary to toxoplasmosis . Arch Otolaryngol Head Neck Surg 1977;103:547-549.Crossref 30. Dudley JP: Epstein-Barr virus and a unilateral neck mass . Arch Otolaryngol Head Neck Surg 1982;108:253-254.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: May 1, 1987

References