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Coagulation Studies in the Newborn Period: IV. Deficiency of Stuart-Prower Factor as a Part of the Clotting Defect of the Newborn

Coagulation Studies in the Newborn Period: IV. Deficiency of Stuart-Prower Factor as a Part of... Abstract In a previous publication1 and in the preceding paper2 we have presented evidence indicating that the serum of newborns with hypoprothrombinemia has a marked deficit of another thromboplastic substance besides PTC. Moreover, in mixture experiments with the thromboplastin generation test and the Loeliger-Koller technique for determination of proconvertin, newborns with severe hypoprothrombinemia appeared to have the same defect as patients receiving prolonged treatment with coumarin compounds. The various deficits of these newborns were corrected by means of stored normal serum.1,2 The recently described Stuart factor3,4 is a stable substance adsorbed by barium sulfate, which participates in the first and probably in the second stage of blood coagulation. Its deficiency is associated with a low thromboplastic activity of the serum and a very prolonged one-stage prothrombin time. The use of Russell viper venom (Stypven) also gives an abnormal result. The determination of proconvertin with a substrate plasma References 1. Aballí, A. J.; Rozengvaig, S.; López Banús, V.; Lamerens, S., and Arrastía, F.: Estudios de la coagulación en el recién Nacido: II. Alteraciones de la Actividad Tromboplástica del Suero , Rev. cubana pediat. 30:337, 1958. 2. Aballí, A. J.; López Banús, V.; Lamerens, S., and Rozengvaig, S.: Coagulation Studies in the Newborn Period: III. Hemorrhagic Disease of the Newborn, this issue, p. 24. 3. Hougie, C.C.; Barrow, E. M., and Graham, J. B.: The Stuart Factor: A Hitherto Unrecognized Blood Coagulation Factor—Proc. of the Sixth Congress of the International Society of Blood Transfusions, p. 336, 1958. 4. Hougie, C.; Barrow, E. M., and Graham, J. B.: Stuart Clotting Defect: I. Segregation of a Hereditary Hemorrhagic State from the Heterogenous Group Heretofore Called "Stable Factor" (SPCA—Proconvertin, Factor VII) Deficiency , J. Clin. Invest. 36:485, 1957.Crossref 5. Bachmann, F.; Duckert, F.; Geiger, M.; Bear, P., and Koller, F.: Differentiation of Factor VII Complex: Studies on the Stuart-Prower Factor , Thrombosis et Diathesis hemorrhagica 1: 168, 1957. 6. Dische, F. E.: Substances with Factor VII Activity , Brit. J. Haemat. 4:202, 1958.Crossref 7. Bachmann, F.; Duckert, F., and Koller, F.: The Stuart-Prower Assay and Its Clinical Significance , Thrombosis et Diathesis hemorrhagica 2:24, 1958. 8. Horder, M. H.: Der Stuart Factor Während der Cumarin Therapie , Thrombosis et Diathesis hemorrhagica 2:170, 1958. 9. Lawson, R. B.: Treatment of Hypoprothrombinemia (Hemorrhagic Disease) of the Newborn , J. Pediat. 18:224, 1941.Crossref 10. Aballí, A. J.; López Banús, V.; Lamerens, S., and Rozengvaig, S.: Coagulation Studies in the Newborn Period: Alterations of Thromboplastin Generation and Effects of Vitamin K in Full-Term and Premature Infants , A. M. A. J. Dis. Child. 94:589, 1957.Crossref 11. Shafrir, E., and de Vries, A.: Studies on Clot-Promoting Activity of Glass , J. Clin. Invest. 35:1183, 1956.Crossref 12. Biggs, R.; Sharp, A. A.; Margolis, J.; Hardesty, R. M.; Stewart, J., and Davidson, W. M.: Defects in the Early Stages of Blood Coagulation , Brit. J. Haemat. 4:177, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Coagulation Studies in the Newborn Period: IV. Deficiency of Stuart-Prower Factor as a Part of the Clotting Defect of the Newborn

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070010551003
Publisher site
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Abstract

Abstract In a previous publication1 and in the preceding paper2 we have presented evidence indicating that the serum of newborns with hypoprothrombinemia has a marked deficit of another thromboplastic substance besides PTC. Moreover, in mixture experiments with the thromboplastin generation test and the Loeliger-Koller technique for determination of proconvertin, newborns with severe hypoprothrombinemia appeared to have the same defect as patients receiving prolonged treatment with coumarin compounds. The various deficits of these newborns were corrected by means of stored normal serum.1,2 The recently described Stuart factor3,4 is a stable substance adsorbed by barium sulfate, which participates in the first and probably in the second stage of blood coagulation. Its deficiency is associated with a low thromboplastic activity of the serum and a very prolonged one-stage prothrombin time. The use of Russell viper venom (Stypven) also gives an abnormal result. The determination of proconvertin with a substrate plasma References 1. Aballí, A. J.; Rozengvaig, S.; López Banús, V.; Lamerens, S., and Arrastía, F.: Estudios de la coagulación en el recién Nacido: II. Alteraciones de la Actividad Tromboplástica del Suero , Rev. cubana pediat. 30:337, 1958. 2. Aballí, A. J.; López Banús, V.; Lamerens, S., and Rozengvaig, S.: Coagulation Studies in the Newborn Period: III. Hemorrhagic Disease of the Newborn, this issue, p. 24. 3. Hougie, C.C.; Barrow, E. M., and Graham, J. B.: The Stuart Factor: A Hitherto Unrecognized Blood Coagulation Factor—Proc. of the Sixth Congress of the International Society of Blood Transfusions, p. 336, 1958. 4. Hougie, C.; Barrow, E. M., and Graham, J. B.: Stuart Clotting Defect: I. Segregation of a Hereditary Hemorrhagic State from the Heterogenous Group Heretofore Called "Stable Factor" (SPCA—Proconvertin, Factor VII) Deficiency , J. Clin. Invest. 36:485, 1957.Crossref 5. Bachmann, F.; Duckert, F.; Geiger, M.; Bear, P., and Koller, F.: Differentiation of Factor VII Complex: Studies on the Stuart-Prower Factor , Thrombosis et Diathesis hemorrhagica 1: 168, 1957. 6. Dische, F. E.: Substances with Factor VII Activity , Brit. J. Haemat. 4:202, 1958.Crossref 7. Bachmann, F.; Duckert, F., and Koller, F.: The Stuart-Prower Assay and Its Clinical Significance , Thrombosis et Diathesis hemorrhagica 2:24, 1958. 8. Horder, M. H.: Der Stuart Factor Während der Cumarin Therapie , Thrombosis et Diathesis hemorrhagica 2:170, 1958. 9. Lawson, R. B.: Treatment of Hypoprothrombinemia (Hemorrhagic Disease) of the Newborn , J. Pediat. 18:224, 1941.Crossref 10. Aballí, A. J.; López Banús, V.; Lamerens, S., and Rozengvaig, S.: Coagulation Studies in the Newborn Period: Alterations of Thromboplastin Generation and Effects of Vitamin K in Full-Term and Premature Infants , A. M. A. J. Dis. Child. 94:589, 1957.Crossref 11. Shafrir, E., and de Vries, A.: Studies on Clot-Promoting Activity of Glass , J. Clin. Invest. 35:1183, 1956.Crossref 12. Biggs, R.; Sharp, A. A.; Margolis, J.; Hardesty, R. M.; Stewart, J., and Davidson, W. M.: Defects in the Early Stages of Blood Coagulation , Brit. J. Haemat. 4:177, 1958.Crossref

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: May 1, 1959

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