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Clorazepate Dipotassium in the Treatment of Intractable Epilepsy

Clorazepate Dipotassium in the Treatment of Intractable Epilepsy Clorazepate dipotassium was given to 59 patients whose epileptic seizures were intractable to treatment with standard antiepileptic drugs. On absorption, clorazepate dipotassium is rapidly decarboxylated to yield N-desmethyl diazepam, a normally occurring metabolite of diazepam. Excellent results were obtained in 20 patients, principally those with generalized minor attacks. Six of these had previously failed to respond to diazepam. No benefit was seen in 14 patients with typical psychomotor attacks. The results suggest that clorazepate dipotassium is a useful addition to the treatment of intractable minor seizures. (JAMA 229:552-555, 1974) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Clorazepate Dipotassium in the Treatment of Intractable Epilepsy

JAMA , Volume 229 (5) – Jul 29, 1974

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1974.03230430044026
Publisher site
See Article on Publisher Site

Abstract

Clorazepate dipotassium was given to 59 patients whose epileptic seizures were intractable to treatment with standard antiepileptic drugs. On absorption, clorazepate dipotassium is rapidly decarboxylated to yield N-desmethyl diazepam, a normally occurring metabolite of diazepam. Excellent results were obtained in 20 patients, principally those with generalized minor attacks. Six of these had previously failed to respond to diazepam. No benefit was seen in 14 patients with typical psychomotor attacks. The results suggest that clorazepate dipotassium is a useful addition to the treatment of intractable minor seizures. (JAMA 229:552-555, 1974)

Journal

JAMAAmerican Medical Association

Published: Jul 29, 1974

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