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Clonidine: Effects of a Topically Administered Solution on Intraocular Pressure and Blood Pressure in Open-Angle Glaucoma

Clonidine: Effects of a Topically Administered Solution on Intraocular Pressure and Blood... Abstract • A double-blind crossover study to determine the effects on intraocular pressure (IOP) and blood pressure of topically instilled 0.125% and 0.25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days. Both clonidine solutions were effective in lowering the IOP; the 0.25% solution was more effective than the 0.125% solution, and the former was slightly less potent than pilocarpine. Pupil diameter was essentially unchanged in all but one of the patients after clonidine. Pilocarpine reduced pupil diameter in all patients. One eye treated with placebo also showed a reduction in pupil size. Both systolic and diastolic blood pressure showed a statistically significant reduction after clonidine, but the magnitude of the change was small. We do not regard the minor blood pressure changes as being a threat to the optic nerve but further studies in this aspect of topical clonidine therapy are required. (Arch Ophthalmol 95:1368-1373, 1977) References 1. Makabe R: Ophthalmological studies with dichlorophenyl-aminoimidazoline . Dtsch Med Wochenschr 91:1686-1688, 1966.Crossref 2. Hasslinger C: Catapres: A new drug lowering intraocular pressure . Klin Monatsbl Augenheilkd 154:95-105, 1969. 3. Heilmann K: Studies of the effect of Catapres in intraocular pressure . Klin Monatsbl Augenheilkd 157:182-192, 1970. 4. Stampfl G: Investigations of the Reducing Effect of Catapres on Ophthalmic Pressure, thesis, Heidelberg, 1970. 5. Scheffe H: The Analysis of Variance . New York, John Wiley & Sons Inc, 1959. 6. Laska E, Gormley M, Sunshine A, et al: A bioassay computer program for analgesic clinical trials . Clin Pharmacol Ther 8:658-669, 1967. 7. Leydhecker V, Hertlein E: Does Catapres decrease the intraocular tension independently of the blood pressure? Klin Monatsbl Augenheilkd 159:574-577, 1971. 8. Jünemann G, Schmidt G: The effect of Catapres on the glaucomatous eye . Klin Monatsbl Augenheilkd 157:193-201, 1970. 9. Jahnke R, Thumm HW: The effect of clonidine on intraocular pressure and pupil diameter . Klin Monatsbl Augenheilkd 161:78-82, 1972. 10. H-J Merte, Heilmann K (eds): Clonidin in der Augenheilkunde (Clonidine in Ophthalmology). Symposium on 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, Munich, Oct 13, 1972 . Stuttgart, West Germany, Ferdinand Enke Verlag, 1974. 11. Conrads H: Catapres for the treatment of glaucoma in general ophthalmic practice . Klin Monatsbl Augenheilkd 162:90-92, 1973. 12. Edelhauser EM: Clinical experience with the local administration of clonidine in glaucoma . Klin Monatsbl Augenheilkd 158:514-517, 1971. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Clonidine: Effects of a Topically Administered Solution on Intraocular Pressure and Blood Pressure in Open-Angle Glaucoma

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450080078007
Publisher site
See Article on Publisher Site

Abstract

Abstract • A double-blind crossover study to determine the effects on intraocular pressure (IOP) and blood pressure of topically instilled 0.125% and 0.25% solutions of clonidine hydrochloride by comparison with a 2% pilocarpine hydrochloride solution and placebo was carried out in a total of 21 patients with open-angle glaucoma, each of whom received a single drop of each preparation in the same glaucomatous eye on separate days. Both clonidine solutions were effective in lowering the IOP; the 0.25% solution was more effective than the 0.125% solution, and the former was slightly less potent than pilocarpine. Pupil diameter was essentially unchanged in all but one of the patients after clonidine. Pilocarpine reduced pupil diameter in all patients. One eye treated with placebo also showed a reduction in pupil size. Both systolic and diastolic blood pressure showed a statistically significant reduction after clonidine, but the magnitude of the change was small. We do not regard the minor blood pressure changes as being a threat to the optic nerve but further studies in this aspect of topical clonidine therapy are required. (Arch Ophthalmol 95:1368-1373, 1977) References 1. Makabe R: Ophthalmological studies with dichlorophenyl-aminoimidazoline . Dtsch Med Wochenschr 91:1686-1688, 1966.Crossref 2. Hasslinger C: Catapres: A new drug lowering intraocular pressure . Klin Monatsbl Augenheilkd 154:95-105, 1969. 3. Heilmann K: Studies of the effect of Catapres in intraocular pressure . Klin Monatsbl Augenheilkd 157:182-192, 1970. 4. Stampfl G: Investigations of the Reducing Effect of Catapres on Ophthalmic Pressure, thesis, Heidelberg, 1970. 5. Scheffe H: The Analysis of Variance . New York, John Wiley & Sons Inc, 1959. 6. Laska E, Gormley M, Sunshine A, et al: A bioassay computer program for analgesic clinical trials . Clin Pharmacol Ther 8:658-669, 1967. 7. Leydhecker V, Hertlein E: Does Catapres decrease the intraocular tension independently of the blood pressure? Klin Monatsbl Augenheilkd 159:574-577, 1971. 8. Jünemann G, Schmidt G: The effect of Catapres on the glaucomatous eye . Klin Monatsbl Augenheilkd 157:193-201, 1970. 9. Jahnke R, Thumm HW: The effect of clonidine on intraocular pressure and pupil diameter . Klin Monatsbl Augenheilkd 161:78-82, 1972. 10. H-J Merte, Heilmann K (eds): Clonidin in der Augenheilkunde (Clonidine in Ophthalmology). Symposium on 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, Munich, Oct 13, 1972 . Stuttgart, West Germany, Ferdinand Enke Verlag, 1974. 11. Conrads H: Catapres for the treatment of glaucoma in general ophthalmic practice . Klin Monatsbl Augenheilkd 162:90-92, 1973. 12. Edelhauser EM: Clinical experience with the local administration of clonidine in glaucoma . Klin Monatsbl Augenheilkd 158:514-517, 1971.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1977

References