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Clonazepam in Treatment of Absence Seizures With Automatisms

Clonazepam in Treatment of Absence Seizures With Automatisms Abstract To the Editor.— Clonazepam (Clonopin), as indicated in the package insert, is not currently recommended in the United States for use in partial seizures with complex symptomatology, although there are a number of articles suggesting that it may be useful in this type of seizure disorder.1-9 The following are two case reports of children with very frequent absence seizures with automatisms who had no response to other anticonvulsants but had very dramatic and sustained seizure control with clonazepam alone. Report of Cases.— Case 1.—A 9-year-old girl had a 11/2-year history of uncontrolled seizures. History, family history, development, physical examination, neurological examination, intelligence, detailed workup, including computerized axial tomography and bilateral selective carotid arteriography were all normal. Clinically, her seizures consisted of absence attacks lasting ten to 60 seconds, which were often accompanied by such automatisms as picking movements with her hands or chewing movements. These occurred ten to 20 References 1. Fazio C, Manfredi M, Piccinelli A: Treatment of epileptic seizures with clonazepam . Arch Neurol 32:304-307, 1975.Crossref 2. Kick H, Dreyer R: Clinical experience with clonazepam (R05-4023) with special reference to psychomotor epilepsy . Epilepsia 14:82-83, 1973. 3. Birket-Smith E, Lund M, Mikkelsen B, et al: A controlled trial on R05-4023 (clonazepam) in the treatment of psychomotor epilepsy . Acta Neurol Scand 49:18-25, 1973.Crossref 4. Lund M, Trolle E: Clonazepam in the treatment of epilepsy . Acta Neurol Scand 49:82-90, 1973.Crossref 5. Mikkelsen B, Birket-Smith E: A clinical study of the benzodiazepine R05-4023 (clonazepam) in the treatment of epilepsy . Acta Neurol Scand 49:91-96, 1973.Crossref 6. Scollo-Lavizzari G: Clinical experience with clonazepam (Rivotril) in the treatment of epilepsy in adults . Epilepsia 15:641, 1974. 7. Lance JW, Anthony M: Sodium valproate and clonazepam in the treatment of intractable epilepsy . Arch Neurol 34:14-17, 1977.Crossref 8. Huang CY, McLeod JG, Sampson D, et al: Clonazepam in the treatment of epilepsy . Med J Aust 2:5-8, 1974. 9. Bensch J, Blennow G, Ferngren H, et al: A double-blind study of clonazepam in the treatment of therapy-resistant epilepsy in children . Devel Med Child Neurol 19:335-342, 1977.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Clonazepam in Treatment of Absence Seizures With Automatisms

Archives of Neurology , Volume 35 (11) – Nov 1, 1978

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1978.00500350077022
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Clonazepam (Clonopin), as indicated in the package insert, is not currently recommended in the United States for use in partial seizures with complex symptomatology, although there are a number of articles suggesting that it may be useful in this type of seizure disorder.1-9 The following are two case reports of children with very frequent absence seizures with automatisms who had no response to other anticonvulsants but had very dramatic and sustained seizure control with clonazepam alone. Report of Cases.— Case 1.—A 9-year-old girl had a 11/2-year history of uncontrolled seizures. History, family history, development, physical examination, neurological examination, intelligence, detailed workup, including computerized axial tomography and bilateral selective carotid arteriography were all normal. Clinically, her seizures consisted of absence attacks lasting ten to 60 seconds, which were often accompanied by such automatisms as picking movements with her hands or chewing movements. These occurred ten to 20 References 1. Fazio C, Manfredi M, Piccinelli A: Treatment of epileptic seizures with clonazepam . Arch Neurol 32:304-307, 1975.Crossref 2. Kick H, Dreyer R: Clinical experience with clonazepam (R05-4023) with special reference to psychomotor epilepsy . Epilepsia 14:82-83, 1973. 3. Birket-Smith E, Lund M, Mikkelsen B, et al: A controlled trial on R05-4023 (clonazepam) in the treatment of psychomotor epilepsy . Acta Neurol Scand 49:18-25, 1973.Crossref 4. Lund M, Trolle E: Clonazepam in the treatment of epilepsy . Acta Neurol Scand 49:82-90, 1973.Crossref 5. Mikkelsen B, Birket-Smith E: A clinical study of the benzodiazepine R05-4023 (clonazepam) in the treatment of epilepsy . Acta Neurol Scand 49:91-96, 1973.Crossref 6. Scollo-Lavizzari G: Clinical experience with clonazepam (Rivotril) in the treatment of epilepsy in adults . Epilepsia 15:641, 1974. 7. Lance JW, Anthony M: Sodium valproate and clonazepam in the treatment of intractable epilepsy . Arch Neurol 34:14-17, 1977.Crossref 8. Huang CY, McLeod JG, Sampson D, et al: Clonazepam in the treatment of epilepsy . Med J Aust 2:5-8, 1974. 9. Bensch J, Blennow G, Ferngren H, et al: A double-blind study of clonazepam in the treatment of therapy-resistant epilepsy in children . Devel Med Child Neurol 19:335-342, 1977.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Nov 1, 1978

References