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Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors

Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced... Key PointsQuestionWhat are the clinicopathologic features of persistent chemotherapy-induced alopecia (pCIA) in breast cancer survivors? FindingsMost patients in this case series presented with either diffuse alopecia or hair thinning in the distribution of female pattern hair loss, with trichoscopic and histopathologic features indistinguishable from those of androgenetic alopecia. A few patients presented with inflammatory scarring alopecia. MeaningThis study suggests that hair follicle miniaturization (the hallmark of androgenetic alopecia) is a prominent feature in pCIA; recognized androgenetic alopecia treatments, including minoxidil and antiandrogen therapy, can also improve hair density for patients with pCIA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2021.3676
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the clinicopathologic features of persistent chemotherapy-induced alopecia (pCIA) in breast cancer survivors? FindingsMost patients in this case series presented with either diffuse alopecia or hair thinning in the distribution of female pattern hair loss, with trichoscopic and histopathologic features indistinguishable from those of androgenetic alopecia. A few patients presented with inflammatory scarring alopecia. MeaningThis study suggests that hair follicle miniaturization (the hallmark of androgenetic alopecia) is a prominent feature in pCIA; recognized androgenetic alopecia treatments, including minoxidil and antiandrogen therapy, can also improve hair density for patients with pCIA.

Journal

JAMA DermatologyAmerican Medical Association

Published: Nov 29, 2021

References