Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Clinicohistopathologic Correlations in Xerophthalmic Ulceration and Necrosis

Clinicohistopathologic Correlations in Xerophthalmic Ulceration and Necrosis Abstract • Corneal tissue from five eyes of three children with active xerophthalmic keratopathy and stromal loss was studied histopathologically. Stromal dissolution was strikingly focal, sometimes occurring beneath an intact epithelium and often, though not always, accompanied by extensive inflammatory reaction and bacteria. References 1. Sommer A, Tarwotjo I, Hussaini G, et al: Incidence, prevalence, and scale of blinding malnutrition . Lancet 1981;1:1407-1408.Crossref 2. Sommer A: Nutritional Blindness: Xerophthalmia and Keratomalacia . New York, Oxford University Press, 1982. 3. Sommer A, Tjakrasudjatma S: Corneal xerophthalmia and keratomalacia . Arch Ophthalmol 1982;100:404-411.Crossref 4. Valenton MJ, Tan RV: Secondary ocular bacterial infection in hypovitaminosis A xerophthalmia . Am J Ophthalmol 1975;80:673-677. 5. Pirie A, Werb Z, Burleigh MC: Collagenase and other proteinases in the cornea of the retinol-deficient rat . Br J Nutr 1975;34:297-311. 6. Pirie A: Effect of vitamin A deficiency on the cornea . Trans Ophthalmol Soc UK 1978;98:357-360. 7. Sommer A, Muhilal H: Nutritional status in corneal xerophthalmia and keratomalacia . Arch Ophthalmol 1982;100:399-403.Crossref 8. Sommer A, Tarwotjo I, Muhilal H, et al: Oral versus intramuscular vitamin A in the treatment of xerophthalmia . Lancet 1980;1:557-559.Crossref 9. Neeld JR, Pearson WN: Macro and micromethods for the determination of serum vitamin A using trifluoroacetic acid . J Nutr 1963;97:454-462. 10. Glover J, Moxley L, Muhilal H, et al: Micromethod for fluorometric assay of retinol-binding protein in blood plasma . Clin Chem Acta 1974;50:371-380.Crossref 11. Mancini G, Carbonara AO, Heremans JF: Immunochemical quantitation of antigens by single radial immunodiffusion . Immunochemistry 1965;2:235-254.Crossref 12. Jelliffe DB: Assessment of the Nutritional Status of the Community . Geneva, World Health Organization, 1966, pp 224-234. 13. Pillat AP: Does keratomalacia exist in adults? Arch Ophthalmol 1929;2:256-287.Crossref 14. Sweet LK, K'ang HJ: Clinical and anatomic study of avitaminosis A among the Chinese . Am J Dis Child 1935;50:699-734. 15. Bloch CE: Clinical investigation of xerophthalmia and dystrophy in infants and young children (xerophthalmia et dystrophia alipogenetica) . J Hyg 1921;19:283-301.Crossref 16. Wason IM: Ophthalmia associated with a dietary deficiency in fat soluble vitamin (A): A study of the pathology . JAMA 1921;76:908-912.Crossref 17. Slansky HH, Gnadinger MC, Itoi M, et al: Collagenase in corneal ulcerations . Arch Ophthalmol 1969;82:108-111.Crossref 18. Dohlman CH, Kalevar V: Cornea in hypovitaminosis A and protein deficiency . Isr J Med Sci 1972;8:1179-1183. 19. Kenyon KR, Berman M, Rose J, et al: Prevention of stromal ulceration in the alkaliburned rabbit cornea by glued-on contact lens: Evidence for the role of polymorphonuclear leukocytes in collagen degradation . Invest Ophthalmol Vis Sci 1979;18:570-587. 20. Johnson-Muller B, Gross J: Regulation of corneal collagenase production: Epithelial-stromal cell interaction . Proc Natl Acad Sci USA 1978;75:4417-4421.Crossref 21. Seng WL, Glogowski JA, Wolf G, et al: The effect of thermal burns on the release of collagenase from corneas of vitamin A-deficient and control rats . Invest Ophthalmol Vis Sci 1980;19:1461-1470. 22. Herbert H: Epithelial xerosis in natives of India . Trans Ophthalmol Soc UK 1896;18:103-104. 23. Kirwan EG, Sen K, Bose N: Nutrition and its bearing on preventable blindness and eye diseases in Bengal . Indian J Med Res 1943;31:49-62. 24. Kuming BS, Politzer WM: Xerophthalmia and protein malnutrition in Bantu children . Br J Ophthalmol 1967;51:649-665.Crossref 25. Ten Doeschatte J: Causes of Blindness in and Around Surabaja, East Java, thesis. Jakarta, Indonesia, 1968, pp 159-241. 26. Bors F, Fells P: Reversal of the complications of self-induced vitamin A deficiency . Br J Ophthalmol 1971;55:210-214.Crossref 27. Mori S: Primary changes in eyes of rats which result from deficiency of fat-soluble A in the diet . JAMA 1922;79:197-200.Crossref 28. Wolbach SB, Howe PR: Tissue changes following deprivation of fat-soluble A vitamin . J Exp Med 1925;42:753-777.Crossref 29. Smith RS, Farrell T, Beiley T: Keratomalacia . Surv Ophthalmol 1975;20:213-219.Crossref 30. Sendele D, Kenyon K, Wolf G, et al: Epithelial abrasion precipitates stromal ulceration in the vitamin A deficient rat cornea . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173. 31. Besson M, Van Horn D, Moulder J, et al: Susceptibility to corneal infection in vitamin A deficient rats reared under conventional and gontobiotic conditions . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173. 32. Burnett J, Smith L, Prause J, et al: Acute inflammatory cells and collagenase in tears of human melting corneas . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Clinicohistopathologic Correlations in Xerophthalmic Ulceration and Necrosis

Loading next page...
 
/lp/american-medical-association/clinicohistopathologic-correlations-in-xerophthalmic-ulceration-and-SY5ExkwsSW
Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030030961014
Publisher site
See Article on Publisher Site

Abstract

Abstract • Corneal tissue from five eyes of three children with active xerophthalmic keratopathy and stromal loss was studied histopathologically. Stromal dissolution was strikingly focal, sometimes occurring beneath an intact epithelium and often, though not always, accompanied by extensive inflammatory reaction and bacteria. References 1. Sommer A, Tarwotjo I, Hussaini G, et al: Incidence, prevalence, and scale of blinding malnutrition . Lancet 1981;1:1407-1408.Crossref 2. Sommer A: Nutritional Blindness: Xerophthalmia and Keratomalacia . New York, Oxford University Press, 1982. 3. Sommer A, Tjakrasudjatma S: Corneal xerophthalmia and keratomalacia . Arch Ophthalmol 1982;100:404-411.Crossref 4. Valenton MJ, Tan RV: Secondary ocular bacterial infection in hypovitaminosis A xerophthalmia . Am J Ophthalmol 1975;80:673-677. 5. Pirie A, Werb Z, Burleigh MC: Collagenase and other proteinases in the cornea of the retinol-deficient rat . Br J Nutr 1975;34:297-311. 6. Pirie A: Effect of vitamin A deficiency on the cornea . Trans Ophthalmol Soc UK 1978;98:357-360. 7. Sommer A, Muhilal H: Nutritional status in corneal xerophthalmia and keratomalacia . Arch Ophthalmol 1982;100:399-403.Crossref 8. Sommer A, Tarwotjo I, Muhilal H, et al: Oral versus intramuscular vitamin A in the treatment of xerophthalmia . Lancet 1980;1:557-559.Crossref 9. Neeld JR, Pearson WN: Macro and micromethods for the determination of serum vitamin A using trifluoroacetic acid . J Nutr 1963;97:454-462. 10. Glover J, Moxley L, Muhilal H, et al: Micromethod for fluorometric assay of retinol-binding protein in blood plasma . Clin Chem Acta 1974;50:371-380.Crossref 11. Mancini G, Carbonara AO, Heremans JF: Immunochemical quantitation of antigens by single radial immunodiffusion . Immunochemistry 1965;2:235-254.Crossref 12. Jelliffe DB: Assessment of the Nutritional Status of the Community . Geneva, World Health Organization, 1966, pp 224-234. 13. Pillat AP: Does keratomalacia exist in adults? Arch Ophthalmol 1929;2:256-287.Crossref 14. Sweet LK, K'ang HJ: Clinical and anatomic study of avitaminosis A among the Chinese . Am J Dis Child 1935;50:699-734. 15. Bloch CE: Clinical investigation of xerophthalmia and dystrophy in infants and young children (xerophthalmia et dystrophia alipogenetica) . J Hyg 1921;19:283-301.Crossref 16. Wason IM: Ophthalmia associated with a dietary deficiency in fat soluble vitamin (A): A study of the pathology . JAMA 1921;76:908-912.Crossref 17. Slansky HH, Gnadinger MC, Itoi M, et al: Collagenase in corneal ulcerations . Arch Ophthalmol 1969;82:108-111.Crossref 18. Dohlman CH, Kalevar V: Cornea in hypovitaminosis A and protein deficiency . Isr J Med Sci 1972;8:1179-1183. 19. Kenyon KR, Berman M, Rose J, et al: Prevention of stromal ulceration in the alkaliburned rabbit cornea by glued-on contact lens: Evidence for the role of polymorphonuclear leukocytes in collagen degradation . Invest Ophthalmol Vis Sci 1979;18:570-587. 20. Johnson-Muller B, Gross J: Regulation of corneal collagenase production: Epithelial-stromal cell interaction . Proc Natl Acad Sci USA 1978;75:4417-4421.Crossref 21. Seng WL, Glogowski JA, Wolf G, et al: The effect of thermal burns on the release of collagenase from corneas of vitamin A-deficient and control rats . Invest Ophthalmol Vis Sci 1980;19:1461-1470. 22. Herbert H: Epithelial xerosis in natives of India . Trans Ophthalmol Soc UK 1896;18:103-104. 23. Kirwan EG, Sen K, Bose N: Nutrition and its bearing on preventable blindness and eye diseases in Bengal . Indian J Med Res 1943;31:49-62. 24. Kuming BS, Politzer WM: Xerophthalmia and protein malnutrition in Bantu children . Br J Ophthalmol 1967;51:649-665.Crossref 25. Ten Doeschatte J: Causes of Blindness in and Around Surabaja, East Java, thesis. Jakarta, Indonesia, 1968, pp 159-241. 26. Bors F, Fells P: Reversal of the complications of self-induced vitamin A deficiency . Br J Ophthalmol 1971;55:210-214.Crossref 27. Mori S: Primary changes in eyes of rats which result from deficiency of fat-soluble A in the diet . JAMA 1922;79:197-200.Crossref 28. Wolbach SB, Howe PR: Tissue changes following deprivation of fat-soluble A vitamin . J Exp Med 1925;42:753-777.Crossref 29. Smith RS, Farrell T, Beiley T: Keratomalacia . Surv Ophthalmol 1975;20:213-219.Crossref 30. Sendele D, Kenyon K, Wolf G, et al: Epithelial abrasion precipitates stromal ulceration in the vitamin A deficient rat cornea . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173. 31. Besson M, Van Horn D, Moulder J, et al: Susceptibility to corneal infection in vitamin A deficient rats reared under conventional and gontobiotic conditions . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173. 32. Burnett J, Smith L, Prause J, et al: Acute inflammatory cells and collagenase in tears of human melting corneas . Invest Ophthalmol Vis Sci 1981;20( (suppl) ):173.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1982

References