Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Clinical Utility of Cycle Exercise for the Physiologic Assessment of Growth Hormone Release in Children

Clinical Utility of Cycle Exercise for the Physiologic Assessment of Growth Hormone Release in... Abstract • The clinical utility of exercise as a stimulus for the physiologic assessment of growth hormone (GH) deficiency was examined in healthy children. In response to exercise tests performed on different days, serum GH concentrations exceeded 7 μg/L on both days in 9 of 10 children. Although there is variation in this method of physiologic testing in the response of serum GH concentration (significant mean differences in GH peak values, 27.1 vs 19.8 μg/L for the two tests), the exercise test proved clinically valid in that diagnostic levels of GH were exceeded on both days 90% of the time. We conclude that this exercise evaluation protocol has clinical utility for the assessment of GH deficiency in children. (AJDC. 1990;144:998-1000) References 1. Blizzard RM. Incidence of growth hormone deficiency: does anyone really know? Growth Genet Horm . 1985;1:4. 2. Vimpani GV, Vimpani AF, Lidgard GP, Cameron EHD, Farquhar JW. Prevalence of severe growth hormone deficiency . Br Med J . 1977;2:427-430.Crossref 3. Buckler JMH. Plasma growth hormone response to exercise as a diagnostic aid . Arch Dis Child . 1973;48:565-567.Crossref 4. Lacey KA, Hewison K, Parkin JM. Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child . 1973;48:508-512.Crossref 5. De San Lazaro C, Parkin JM, Turner SJ. Treadmill exercise in short children . Arch Dis Child . 1984;59:1179-1181.Crossref 6. Nicoll AG, Smail PJ, Forsyth CC. Exercise test for growth hormone deficiency . Arch Dis Child . 1984;59:1177-1178.Crossref 7. Parkin JM. Exercise as test of growth hormone secretion . Acta Endocrinol Suppl . 1986; 279:47-50. 8. Bar-Or O. Pediatric Sports Medicine for the Practitioner . New York, NY: Springer-Verlag; 1983:306. 9. Daniel WD. Biostatistics: A Foundation for Analysis in the Health Sciences . New York, NY: John Wiley & Sons Inc; 1983. 10. Frasier SD. A review of growth hormone stimulation tests in children . Pediatrics . 1974; 53:929-937. 11. Raynaud J, Capderou A, Martineaud J-P, Bordachar J, Durand J. Intersubject variability in growth hormone time course during different types of work . J Appl Physiol . 1983;55:1682-1687. 12. Wahrenberg WB, Ling N, Bohlen P, Esch F, Brazeau P, Guillemin R. Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion . Biochem Biophys Res Commun . 1982;105:562-567.Crossref 13. Tannnenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion . Endocrinology . 1984;115: 1952-1957.Crossref 14. Vance ML, Borges JLC, Kaiser DL, et al. Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man . J Clin Endocrinol Metab . 1984;58:838-844.Crossref 15. Martha PM Jr, Blizzard RM, Rogol AD. Atenolol enhances growth hormone release to growth hormone–releasing hormone but fails to alter spontaneous nocturnal growth hormone secretion in boys with constitutional delay of growth . Pediatr Res . 1988;23:393-397.Crossref 16. Reiter EO, Morris AH, MacGillivray MH, Weber D. Variable estimates of serum growth hormone concentrations by different radioassay systems . J Clin Endocrinol Metab . 1988;66:68-71.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Clinical Utility of Cycle Exercise for the Physiologic Assessment of Growth Hormone Release in Children

Loading next page...
 
/lp/american-medical-association/clinical-utility-of-cycle-exercise-for-the-physiologic-assessment-of-mh4xt3fAb4
Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1990.02150330058021
Publisher site
See Article on Publisher Site

Abstract

Abstract • The clinical utility of exercise as a stimulus for the physiologic assessment of growth hormone (GH) deficiency was examined in healthy children. In response to exercise tests performed on different days, serum GH concentrations exceeded 7 μg/L on both days in 9 of 10 children. Although there is variation in this method of physiologic testing in the response of serum GH concentration (significant mean differences in GH peak values, 27.1 vs 19.8 μg/L for the two tests), the exercise test proved clinically valid in that diagnostic levels of GH were exceeded on both days 90% of the time. We conclude that this exercise evaluation protocol has clinical utility for the assessment of GH deficiency in children. (AJDC. 1990;144:998-1000) References 1. Blizzard RM. Incidence of growth hormone deficiency: does anyone really know? Growth Genet Horm . 1985;1:4. 2. Vimpani GV, Vimpani AF, Lidgard GP, Cameron EHD, Farquhar JW. Prevalence of severe growth hormone deficiency . Br Med J . 1977;2:427-430.Crossref 3. Buckler JMH. Plasma growth hormone response to exercise as a diagnostic aid . Arch Dis Child . 1973;48:565-567.Crossref 4. Lacey KA, Hewison K, Parkin JM. Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child . 1973;48:508-512.Crossref 5. De San Lazaro C, Parkin JM, Turner SJ. Treadmill exercise in short children . Arch Dis Child . 1984;59:1179-1181.Crossref 6. Nicoll AG, Smail PJ, Forsyth CC. Exercise test for growth hormone deficiency . Arch Dis Child . 1984;59:1177-1178.Crossref 7. Parkin JM. Exercise as test of growth hormone secretion . Acta Endocrinol Suppl . 1986; 279:47-50. 8. Bar-Or O. Pediatric Sports Medicine for the Practitioner . New York, NY: Springer-Verlag; 1983:306. 9. Daniel WD. Biostatistics: A Foundation for Analysis in the Health Sciences . New York, NY: John Wiley & Sons Inc; 1983. 10. Frasier SD. A review of growth hormone stimulation tests in children . Pediatrics . 1974; 53:929-937. 11. Raynaud J, Capderou A, Martineaud J-P, Bordachar J, Durand J. Intersubject variability in growth hormone time course during different types of work . J Appl Physiol . 1983;55:1682-1687. 12. Wahrenberg WB, Ling N, Bohlen P, Esch F, Brazeau P, Guillemin R. Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion . Biochem Biophys Res Commun . 1982;105:562-567.Crossref 13. Tannnenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion . Endocrinology . 1984;115: 1952-1957.Crossref 14. Vance ML, Borges JLC, Kaiser DL, et al. Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man . J Clin Endocrinol Metab . 1984;58:838-844.Crossref 15. Martha PM Jr, Blizzard RM, Rogol AD. Atenolol enhances growth hormone release to growth hormone–releasing hormone but fails to alter spontaneous nocturnal growth hormone secretion in boys with constitutional delay of growth . Pediatr Res . 1988;23:393-397.Crossref 16. Reiter EO, Morris AH, MacGillivray MH, Weber D. Variable estimates of serum growth hormone concentrations by different radioassay systems . J Clin Endocrinol Metab . 1988;66:68-71.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1990

References