Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

CLINICAL TRIALS WITH QUININEEPINEPHRINE INTRAVENOUSLY

CLINICAL TRIALS WITH QUININEEPINEPHRINE INTRAVENOUSLY The successful current use of quinacrine (atabrine), orally and intramuscularly, in treating malaria has not relegated quinine to the scrap-heap of obsolete medicinals for this infection. Quinine has been widely used intravenously in civilian practice and in the armed services as an emergency measure in, or for initiating treatment of, the embolic or cerebral form of the disease, especially with coma. The effectiveness of the quinine, under these conditions, has not been challenged, but the safeness of the procedure has been considerably debated. In general, clinical reports1 have been rather opinionated without substantial support of the claims for or against using quinine intravenously. The possible hazard in the circulatory depression from quinine has been consistently recognized, although the intravenous procedures used have not always considered measures for controlling or combating this. The alkaloid has been given empirically with or without an antagonist. Intravenous epinephrine has been condemned by some http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

CLINICAL TRIALS WITH QUININEEPINEPHRINE INTRAVENOUSLY

JAMA , Volume 129 (18) – Dec 29, 1945

Loading next page...
 
/lp/american-medical-association/clinical-trials-with-quinineepinephrine-intravenously-3kH2XKTImp

References (9)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1945.02860520009002
Publisher site
See Article on Publisher Site

Abstract

The successful current use of quinacrine (atabrine), orally and intramuscularly, in treating malaria has not relegated quinine to the scrap-heap of obsolete medicinals for this infection. Quinine has been widely used intravenously in civilian practice and in the armed services as an emergency measure in, or for initiating treatment of, the embolic or cerebral form of the disease, especially with coma. The effectiveness of the quinine, under these conditions, has not been challenged, but the safeness of the procedure has been considerably debated. In general, clinical reports1 have been rather opinionated without substantial support of the claims for or against using quinine intravenously. The possible hazard in the circulatory depression from quinine has been consistently recognized, although the intravenous procedures used have not always considered measures for controlling or combating this. The alkaloid has been given empirically with or without an antagonist. Intravenous epinephrine has been condemned by some

Journal

JAMAAmerican Medical Association

Published: Dec 29, 1945

There are no references for this article.