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Clinical Trials of RA 27/3 (Wistar) Rubella Vaccine in Japan

Clinical Trials of RA 27/3 (Wistar) Rubella Vaccine in Japan Abstract THREE trials were conducted in Nagoya, Japan, testing the safety, antigenicity, contagiousness, and transplacental passage of RA27/3. Trial 1 was performed with children in a closed orphanage and with nurses attached to two hospitals in Nagoya. Most of the 43 seronegative subjects in the orphanage were between 1 and 2 years of age, with a range from 8 to 35 months. The other subjects were 16 adult women whose ages ranged from 19 to 25 years. In the orphanage, seven rubella susceptible uninoculated children were placed in two rooms where there was ample opportunity for close contact with inoculated children, while playing and napping together. In the other two trials, the subjects were selected from nursing students at another hospital; 105 were seropositive, and 21 were seronegative. The total number inoculated in the three trials, therefore, included 80 seronegative and 111 seropositive subjects. Of the seronegative subjects, 37 were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040264021
Publisher site
See Article on Publisher Site

Abstract

Abstract THREE trials were conducted in Nagoya, Japan, testing the safety, antigenicity, contagiousness, and transplacental passage of RA27/3. Trial 1 was performed with children in a closed orphanage and with nurses attached to two hospitals in Nagoya. Most of the 43 seronegative subjects in the orphanage were between 1 and 2 years of age, with a range from 8 to 35 months. The other subjects were 16 adult women whose ages ranged from 19 to 25 years. In the orphanage, seven rubella susceptible uninoculated children were placed in two rooms where there was ample opportunity for close contact with inoculated children, while playing and napping together. In the other two trials, the subjects were selected from nursing students at another hospital; 105 were seropositive, and 21 were seronegative. The total number inoculated in the three trials, therefore, included 80 seronegative and 111 seropositive subjects. Of the seronegative subjects, 37 were

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

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