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CLINICAL STUDIES OF VITAMIN A IN INFANTS AND IN CHILDREN

CLINICAL STUDIES OF VITAMIN A IN INFANTS AND IN CHILDREN During the past three years, a convenient method of estimating vitamin A in small quantities of blood has been developed and applied to the problems of early clinical diagnosis of deficiency of vitamin A and the metabolism of vitamin A in health and in disease. The clinical diagnosis of vitamin A deficiency, before the development of the characteristic keratomalacia, has been dependent on the recognition of early signs, as described by Blackfan and Wolbach.1 They pointed out that the most dependable early sign is the appearance of cornified epithelial cells in sites where they do not normally occur, for example, nose, trachea, kidneys and vagina.2 Yet even this evidence of deficiency of vitamin A may be considered a relatively late sign, as it appears only after weeks or months of almost complete deprivation of vitamin A. Quantitative measurement of night blindness has been proposed as an indirect approach http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

CLINICAL STUDIES OF VITAMIN A IN INFANTS AND IN CHILDREN

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1940.01990170003001
Publisher site
See Article on Publisher Site

Abstract

During the past three years, a convenient method of estimating vitamin A in small quantities of blood has been developed and applied to the problems of early clinical diagnosis of deficiency of vitamin A and the metabolism of vitamin A in health and in disease. The clinical diagnosis of vitamin A deficiency, before the development of the characteristic keratomalacia, has been dependent on the recognition of early signs, as described by Blackfan and Wolbach.1 They pointed out that the most dependable early sign is the appearance of cornified epithelial cells in sites where they do not normally occur, for example, nose, trachea, kidneys and vagina.2 Yet even this evidence of deficiency of vitamin A may be considered a relatively late sign, as it appears only after weeks or months of almost complete deprivation of vitamin A. Quantitative measurement of night blindness has been proposed as an indirect approach

Journal

American journal of diseases of children – American Medical Association

Published: Jun 1, 1940

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