Abstract THERE is a trend on the part of dermatologists toward prescription of washable ointment bases as vehicles for medicinals employed in topical therapy. The recognition of the fact that there is considerably increased absorption of therapeutic agents from such bases in comparison with the absorption from the traditional oleaginous bases has led to the present investigation, which is concerned with the quantitative evaluation of the comparative increase in absorption. An increase in the absorption and penetration of medicinals from ointment bases has obvious advantages. The release of antiseptics incorporated into water-soluble bases has been shown to be more rapid and complete than that from water-immiscible bases1; diffusion of medicaments into the diseased area occurs more readily, and lower concentrations of active ingredients suffice to produce a comparable therapeutic response, this fact resulting in considerable saving in cost with expensive medicinals. On the other hand, indiscriminate use of such References 1. Meyers, D. B.; Nadkarni, M. V., and Zopf, L. C.: J. Am. Pharm. A. (Scient. Ed.) 38:231, 1949.Crossref 2. Strakosch, E. A.: Studies on Ointments: Ointments Containing Sulphur , Arch. Dermat. & Syph. 47:216 ( (Feb.) ) 1943. 3. Sannicaudro, G.: Dermasifilografa 12:273, 1937. 4. Neuroth, M. L., and Lee, C. O.: J. Am. Pharm. A. (Pract. Pharm. Ed.) 6:285, 1945. 5. Luff, A. P.: Pharm. J. 50:206, 1891. 6. Breslauer, E.: Ztschr. f. Hyg. u. Infectionskr. 20:165, 1895. 7. Craw, R. O., and Lee, C. O.: Pharm. Arch. 9:1, 1938. 8. Seelman, J. V.: Absorption of Drugs and Poisons Through the Skin, Correspondence , J. A. M. A. 110:1127 ( (April 2) ) 1938. 9. Brown, E. W., and Scott, W. O.: J. Pharmacol. & Exper. Therap. 50:273, 1934. 10. Macht, D. I.: Absorption of Drugs and Poisons Through Skin and Mucous Membranes , J. A. M. A. 110:409 ( (Feb. 5) ) 1938. 11. Duemling, W. W.: Wetting Agents: New Synthetic Chemicals of Use in Finer and More Efficient Topical Dermatologic Therapy , Arch. Dermat. & Syph. 43:264 ( (Feb.) ) 1941.
A.M.A. Archives of Dermatology & Syphilology – American Medical Association
Published: Sep 1, 1951