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Clinical Observations on the Solitary Autonomous Thyroid Nodule

Clinical Observations on the Solitary Autonomous Thyroid Nodule Abstract Of 54 patients with solitary autonomous thyroid nodules (SAN), only one or perhaps two manifested signs or symptoms of hyperthyroidism. Eighteen of the 54 patients had nodules that were larger than 3 cm in diameter, but only one of these patients had possible thyrotoxicosis. Forty-eight of the 54 patients were followed up for 4 to 136 months (average, 24 months). The course of the disease was completely benign, and none of these subjects developed hyperthyroidism during the follow-up. Two of the 48 patients appeared to have a SAN that underwent degeneration during the study. We think that euthyroid patients with SAN may be managed under most circumstances by periodic follow-up examinations and that they need to be subjected to surgical or radioactive iodine therapy only when and if they subsequently develop hyperthyroidism. References 1. Miller JM, Block MA: The autonomous functioning thyroid nodule. Arch Surg 95:386-393, 1968.Crossref 2. Silverstein GF, Burke G, Cogan R: The natural history of the autonomous hyperfunctioning thyroid nodule. Ann Intern Med 67:539-548, 1967.Crossref 3. McCormack KR, Sheline GE: Long term studies of solitary autonomous thyroid nodules. J Nucl Med 8:701-708, 1967. 4. Molnar GD, et al: On the hyperfunctioning solitary thyroid nodule. Mayo Clinic Proc 40:665-684, 1965. 5. Skillern PG, McCullagh EP, Clamen M: Radioiodine in diagnosis and therapy of hyperthyroidism; hyperthyroidism caused by a hyperfunctioning adenoma. Arch Intern Med 110:888-897, 1962.Crossref 6. Ferriman D, Hennebry TM, Tassopoulos CN: True thyroid adenoma. Q J Med 16:127-139, 1972. 7. Ermans AM, Camus M: Modifications of thyroid function induced by chronic administration of iodide in the presence of "autonomous" thyroid tissue. Acta Endocrinol 70:463-475, 1972. 8. Park HM, et al: Clinical-physiological correlations in patients with a hot nodule of the thyroid. Endrocrinology 92( (suppl) ):T-13, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Clinical Observations on the Solitary Autonomous Thyroid Nodule

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1974.00320230125024
Publisher site
See Article on Publisher Site

Abstract

Abstract Of 54 patients with solitary autonomous thyroid nodules (SAN), only one or perhaps two manifested signs or symptoms of hyperthyroidism. Eighteen of the 54 patients had nodules that were larger than 3 cm in diameter, but only one of these patients had possible thyrotoxicosis. Forty-eight of the 54 patients were followed up for 4 to 136 months (average, 24 months). The course of the disease was completely benign, and none of these subjects developed hyperthyroidism during the follow-up. Two of the 48 patients appeared to have a SAN that underwent degeneration during the study. We think that euthyroid patients with SAN may be managed under most circumstances by periodic follow-up examinations and that they need to be subjected to surgical or radioactive iodine therapy only when and if they subsequently develop hyperthyroidism. References 1. Miller JM, Block MA: The autonomous functioning thyroid nodule. Arch Surg 95:386-393, 1968.Crossref 2. Silverstein GF, Burke G, Cogan R: The natural history of the autonomous hyperfunctioning thyroid nodule. Ann Intern Med 67:539-548, 1967.Crossref 3. McCormack KR, Sheline GE: Long term studies of solitary autonomous thyroid nodules. J Nucl Med 8:701-708, 1967. 4. Molnar GD, et al: On the hyperfunctioning solitary thyroid nodule. Mayo Clinic Proc 40:665-684, 1965. 5. Skillern PG, McCullagh EP, Clamen M: Radioiodine in diagnosis and therapy of hyperthyroidism; hyperthyroidism caused by a hyperfunctioning adenoma. Arch Intern Med 110:888-897, 1962.Crossref 6. Ferriman D, Hennebry TM, Tassopoulos CN: True thyroid adenoma. Q J Med 16:127-139, 1972. 7. Ermans AM, Camus M: Modifications of thyroid function induced by chronic administration of iodide in the presence of "autonomous" thyroid tissue. Acta Endocrinol 70:463-475, 1972. 8. Park HM, et al: Clinical-physiological correlations in patients with a hot nodule of the thyroid. Endrocrinology 92( (suppl) ):T-13, 1973.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1974

References