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Clinical Notes, Suggestions and New Instruments

Clinical Notes, Suggestions and New Instruments MENINGITIS DUE TO ESCHERICHIA COLI TREATED WITH STREPTOMYCIN LIEUTENANT COLONEL ALEXANDER J. ALEXANDER M. C., A. U. S. (Inactive Status) Lexington, Ky. Meningitis due to Escherichia coli is fortunately not common. It is most frequently found in newborn infants. Occasionally it is secondary to bacteremia or to wounds penetrating the meninges, especially when there is fecal contamination. Strong and Edwards1 reported a case of meningitis due to E. coli following a wound in which a bullet had lodged in the sacrum, penetrating the spinal canal. Recovery followed the removal of the foreign body with drainage of a previously undiscovered subdural abscess and therapy with large doses of sulfadiazine. Such fortunate results are not common, and in most cases the sulfonamides have little or no effect on organisms of the colon-typhoid group. Until recently the prognosis in meningitis due to E. coli has been extremely poor, and the mortality rate exceedingly high, owing largely to the lack of an effective chemotherapeutic or antibiotic agent. The recent development of new antibiotics, particularly streptomycin, has raised the first ray of hope in the treatment of this condition. Streptomycin is known to have a definite effect on E. coli and on other gram-negative organisms in vitro.2 There is evidence in unpublished reports from several sources that streptomycin is effective in vivo against many of these organisms. No references, either in the medical literature or in unpublished http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Clinical Notes, Suggestions and New Instruments

JAMA , Volume 131 (8) – Jun 22, 1946
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Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1946.02870250017006
Publisher site
See Article on Publisher Site

Abstract

MENINGITIS DUE TO ESCHERICHIA COLI TREATED WITH STREPTOMYCIN LIEUTENANT COLONEL ALEXANDER J. ALEXANDER M. C., A. U. S. (Inactive Status) Lexington, Ky. Meningitis due to Escherichia coli is fortunately not common. It is most frequently found in newborn infants. Occasionally it is secondary to bacteremia or to wounds penetrating the meninges, especially when there is fecal contamination. Strong and Edwards1 reported a case of meningitis due to E. coli following a wound in which a bullet had lodged in the sacrum, penetrating the spinal canal. Recovery followed the removal of the foreign body with drainage of a previously undiscovered subdural abscess and therapy with large doses of sulfadiazine. Such fortunate results are not common, and in most cases the sulfonamides have little or no effect on organisms of the colon-typhoid group. Until recently the prognosis in meningitis due to E. coli has been extremely poor, and the mortality rate exceedingly high, owing largely to the lack of an effective chemotherapeutic or antibiotic agent. The recent development of new antibiotics, particularly streptomycin, has raised the first ray of hope in the treatment of this condition. Streptomycin is known to have a definite effect on E. coli and on other gram-negative organisms in vitro.2 There is evidence in unpublished reports from several sources that streptomycin is effective in vivo against many of these organisms. No references, either in the medical literature or in unpublished

Journal

JAMA – American Medical Association

Published: Jun 22, 1946

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