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Clinical Bone-Marrow Transplantation Workshop

Clinical Bone-Marrow Transplantation Workshop To the Editor.— A workshop on human bone-marrow transplantation was held at the University of California at Davis on Dec 1, 1971. Attending were those scientists largely responsible for the 133 bone-marrow transplant attempts in 119 patients which have been reported to the American College of Surgeons/National Institutes of Health (ACS/NIH) BoneMarrow Transplant Registry. Complete or partial immunological reconstitution of children with a variety of immunological deficiency diseases was reported. In addition, several cases of successful allogenic bone-marrow grafts were cited in patients with aplastic anemia who had been refractory to previous therapies. Prior to allogenic bone-marrow transplantation, the patients with aplastic anemia received intensive immunosuppressive therapy utilizing antilymphocyte globulin or cyclophosphamide in order to prevent graft rejection. The subsequent demonstration of normal immunological or hematopoietic function plus a donor immunological or hematopoietic marker (eg, a change to donor serum immunoglobulin allotype, donor hematopoietic or lymphoid karyotype, or a change http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Clinical Bone-Marrow Transplantation Workshop

Bortin, Mortimer M.; Rogentine, G. Nicholas
JAMA , Volume 221 (5) – Jul 31, 1972
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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1972.03200180050021
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— A workshop on human bone-marrow transplantation was held at the University of California at Davis on Dec 1, 1971. Attending were those scientists largely responsible for the 133 bone-marrow transplant attempts in 119 patients which have been reported to the American College of Surgeons/National Institutes of Health (ACS/NIH) BoneMarrow Transplant Registry. Complete or partial immunological reconstitution of children with a variety of immunological deficiency diseases was reported. In addition, several cases of successful allogenic bone-marrow grafts were cited in patients with aplastic anemia who had been refractory to previous therapies. Prior to allogenic bone-marrow transplantation, the patients with aplastic anemia received intensive immunosuppressive therapy utilizing antilymphocyte globulin or cyclophosphamide in order to prevent graft rejection. The subsequent demonstration of normal immunological or hematopoietic function plus a donor immunological or hematopoietic marker (eg, a change to donor serum immunoglobulin allotype, donor hematopoietic or lymphoid karyotype, or a change

Journal

JAMA – American Medical Association

Published: Jul 31, 1972

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