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CLINICAL AND SEROLOGIC VALUE OF THE COLLOIDAL BENZOIN REACTION

CLINICAL AND SEROLOGIC VALUE OF THE COLLOIDAL BENZOIN REACTION Abstract There is an urgent need of a simple, inexpensive and reliable serologic test to differentiate general paresis, and especially incipient general paresis, from other forms of neurosyphilis. The colloidal benzoin reaction of the spinal fluid, first advocated by Guillain, Laroche, and Lechelle1 as a specific test for neurosyphilis seems more nearly to fulfil these requirements than either the Lange2 colloidal gold test or the gum mastic test of Emanuel.3 Warwick and Nixon,4 using the colloidal gold test, found that out of a total number of twenty spinal fluids from paretic patients, there were two so-called second or tabetic zone curves, and out of seventy-three spinal fluids from tabetic patients there were seven so-called first or paretic zone curves. The error was about 10 per cent, in each. Warwick5 later, in discussing the effect of treatment on the colloidal gold reaction, gave the curves obtained with References 1. Guillain, G.; Laroche, G., and Lechelle, P.: La réaction du benzoin colloidal; sa technique, sa valeur sémiologique , Presse méd. 2:773-777, 1921. 2. Lange, Carl: Ueber die Ausflockung von Goldsol durch Liquor cerebrospinalis , Berl. klin. Wchnschr. 1:897-901, 1912. 3. Emanuel, G.: Eine neue Reaktion zur Untersuchung des Liquor cerebrospinalis , Berl. klin. Wchnschr. 2:792-794, 1915. 4. Warwick, Margaret, and Nixon, C. E.: Study of Colloidal Gold Reaction and Its Clinical Interpretation , Arch. Int. Med. 25:119-145 ( (Feb.) ) 1920.Crossref 5. Warwick, Margaret: The Effect of Antisyphilitic Treatment on the Colloidal Gold Reaction , Arch. Int. Med. 27:238-254, 1921.Crossref 6. Vogel, K. M.: The Nature and Interpretation of the Colloidal Gold Reaction , Arch. Int. Med. 22:496-516, 1918.Crossref 7. Swift, H. F., and Ellis, A W. M.: A Study of the Spirochaeticidal Action of the Serum of Patients Treated with Salvarsan , J. Exper. M. 18:435-449, 1913.Crossref 8. Smith, E. R.: The Mastic Reaction on the Cerebrospinal Fluid , Med. Rec. 92:675-678, 1917. 9. Stanton, J. M.: Concerning the Colloidal Mastic Test , Arch. Neurol. & Psychiat. 4:301-308 ( (Sept.) ) 1920. 10. Camp, C. D.: The Colloidal Mastic Test on Cerebrospinal Fluid , Am. J. Syph. 4:301-308, 1920. 11. Keidel, A., and Moore, J. E.: Comparative Results of Colloidal Mastic and Colloidal Gold Tests , Arch. Neurol. & Psychiat. 6:163-172 ( (Aug.) ) 1921. 12. Urechia, C. J., and Jorgulescu, N.: L'épreuve colloidal au mastic d'Emmanuel, dans le liquide cephalo-rachidien , Compt. rend. Soc. de biol. 79:893-894, 1916. 13. Eskuchen, K.: Die klinische Brauchbarkeit der Kolloidreaktionen des Liquor cerebrospinalis , Neurol. Centralbl. 37:482-490, 1918. 14. Stern, Felix, and Poensgen, Fritz: Der Wert der Mastixreaktion unter den Kolloidreaktionen des Liquor cerebrospinalis , Berl. klin. Wchnschr. 2:634-636, 1920. 15. Bonsmann, M. R.: Vergleichende Untersuchungen über Kolloidreaktionen im Liquor cerebrospinalis , Deutsch. Arch. f. klin. Med. 134:20-36, 1920. 16. Schönfeld, W.: Ueber die Mastixreaktion (Emanuels) und ihre Stellung zu anderen Reaktionen in der Rückenmarksflüssigkeit , München med. Wchnschr. 1:482-484, 1920 17. Ueber Befunde in der Rückenmarksflüssigkeit bei nervengesunden Menschen , Deutsch. Ztschr. f. Nervenh. 64:300-322, 1919 18. Riddel, D. O., and Stewart, R. M.: A Comparative Study of Three Colloidal Reactions on the Cerebrospinal Fluid , J. Neurol. & Psychiat. 2:325-336. 1921-1922 19. Spirochaetosis of the Cerebrospinal Fluid , Med. Rec. 92:675-678, 1917 20. Warnock, Fanny: The Colloidal Benzoin Reaction of Cerebrospinal Fluid , J. Lab. & Clin. Med. 7:400-409, 1922. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

CLINICAL AND SEROLOGIC VALUE OF THE COLLOIDAL BENZOIN REACTION

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American Medical Association
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Copyright © 1925 American Medical Association. All Rights Reserved.
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0096-6029
DOI
10.1001/archderm.1925.02370110095011
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Abstract

Abstract There is an urgent need of a simple, inexpensive and reliable serologic test to differentiate general paresis, and especially incipient general paresis, from other forms of neurosyphilis. The colloidal benzoin reaction of the spinal fluid, first advocated by Guillain, Laroche, and Lechelle1 as a specific test for neurosyphilis seems more nearly to fulfil these requirements than either the Lange2 colloidal gold test or the gum mastic test of Emanuel.3 Warwick and Nixon,4 using the colloidal gold test, found that out of a total number of twenty spinal fluids from paretic patients, there were two so-called second or tabetic zone curves, and out of seventy-three spinal fluids from tabetic patients there were seven so-called first or paretic zone curves. The error was about 10 per cent, in each. Warwick5 later, in discussing the effect of treatment on the colloidal gold reaction, gave the curves obtained with References 1. Guillain, G.; Laroche, G., and Lechelle, P.: La réaction du benzoin colloidal; sa technique, sa valeur sémiologique , Presse méd. 2:773-777, 1921. 2. Lange, Carl: Ueber die Ausflockung von Goldsol durch Liquor cerebrospinalis , Berl. klin. Wchnschr. 1:897-901, 1912. 3. Emanuel, G.: Eine neue Reaktion zur Untersuchung des Liquor cerebrospinalis , Berl. klin. Wchnschr. 2:792-794, 1915. 4. Warwick, Margaret, and Nixon, C. E.: Study of Colloidal Gold Reaction and Its Clinical Interpretation , Arch. Int. Med. 25:119-145 ( (Feb.) ) 1920.Crossref 5. Warwick, Margaret: The Effect of Antisyphilitic Treatment on the Colloidal Gold Reaction , Arch. Int. Med. 27:238-254, 1921.Crossref 6. Vogel, K. M.: The Nature and Interpretation of the Colloidal Gold Reaction , Arch. Int. Med. 22:496-516, 1918.Crossref 7. Swift, H. F., and Ellis, A W. M.: A Study of the Spirochaeticidal Action of the Serum of Patients Treated with Salvarsan , J. Exper. M. 18:435-449, 1913.Crossref 8. Smith, E. R.: The Mastic Reaction on the Cerebrospinal Fluid , Med. Rec. 92:675-678, 1917. 9. Stanton, J. M.: Concerning the Colloidal Mastic Test , Arch. Neurol. & Psychiat. 4:301-308 ( (Sept.) ) 1920. 10. Camp, C. D.: The Colloidal Mastic Test on Cerebrospinal Fluid , Am. J. Syph. 4:301-308, 1920. 11. Keidel, A., and Moore, J. E.: Comparative Results of Colloidal Mastic and Colloidal Gold Tests , Arch. Neurol. & Psychiat. 6:163-172 ( (Aug.) ) 1921. 12. Urechia, C. J., and Jorgulescu, N.: L'épreuve colloidal au mastic d'Emmanuel, dans le liquide cephalo-rachidien , Compt. rend. Soc. de biol. 79:893-894, 1916. 13. Eskuchen, K.: Die klinische Brauchbarkeit der Kolloidreaktionen des Liquor cerebrospinalis , Neurol. Centralbl. 37:482-490, 1918. 14. Stern, Felix, and Poensgen, Fritz: Der Wert der Mastixreaktion unter den Kolloidreaktionen des Liquor cerebrospinalis , Berl. klin. Wchnschr. 2:634-636, 1920. 15. Bonsmann, M. R.: Vergleichende Untersuchungen über Kolloidreaktionen im Liquor cerebrospinalis , Deutsch. Arch. f. klin. Med. 134:20-36, 1920. 16. Schönfeld, W.: Ueber die Mastixreaktion (Emanuels) und ihre Stellung zu anderen Reaktionen in der Rückenmarksflüssigkeit , München med. Wchnschr. 1:482-484, 1920 17. Ueber Befunde in der Rückenmarksflüssigkeit bei nervengesunden Menschen , Deutsch. Ztschr. f. Nervenh. 64:300-322, 1919 18. Riddel, D. O., and Stewart, R. M.: A Comparative Study of Three Colloidal Reactions on the Cerebrospinal Fluid , J. Neurol. & Psychiat. 2:325-336. 1921-1922 19. Spirochaetosis of the Cerebrospinal Fluid , Med. Rec. 92:675-678, 1917 20. Warnock, Fanny: The Colloidal Benzoin Reaction of Cerebrospinal Fluid , J. Lab. & Clin. Med. 7:400-409, 1922.

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Nov 1, 1925

References

  • La réaction du benzoin colloidal
    Guillain , G.; Laroche, G., and Lechelle, P.
  • Ueber die Ausflockung von Goldsol durch Liquor cerebrospinalis
    Lange , Carl
  • Eine neue Reaktion zur Untersuchung des Liquor cerebrospinalis
    Emanuel , G.
  • Study of Colloidal Gold Reaction and Its Clinical Interpretation
    Warwick , Margaret, and Nixon, C. E.
  • The Effect of Antisyphilitic Treatment on the Colloidal Gold Reaction
    Warwick , Margaret
  • The Nature and Interpretation of the Colloidal Gold Reaction
    Vogel , K. M.
  • A Study of the Spirochaeticidal Action of the Serum of Patients Treated with Salvarsan
    Swift , H. F., and Ellis, A W. M.
  • The Mastic Reaction on the Cerebrospinal Fluid
    Smith , E. R.
  • Concerning the Colloidal Mastic Test
    Stanton , J. M.
  • The Colloidal Mastic Test on Cerebrospinal Fluid
    Camp , C. D.
  • Comparative Results of Colloidal Mastic and Colloidal Gold Tests
    Keidel , A., and Moore, J. E.
  • L'épreuve colloidal au mastic d'Emmanuel, dans le liquide cephalo-rachidien
    Urechia , C. J., and Jorgulescu, N.
  • Die klinische Brauchbarkeit der Kolloidreaktionen des Liquor cerebrospinalis
    Eskuchen , K.
  • Der Wert der Mastixreaktion unter den Kolloidreaktionen des Liquor cerebrospinalis
    Stern , Felix, and Poensgen, Fritz
  • Vergleichende Untersuchungen über Kolloidreaktionen im Liquor cerebrospinalis
    Bonsmann , M. R.
  • Ueber die Mastixreaktion (Emanuels) und ihre Stellung zu anderen Reaktionen in der Rückenmarksflüssigkeit
    Schönfeld , W.
  • Ueber Befunde in der Rückenmarksflüssigkeit bei nervengesunden Menschen
  • A Comparative Study of Three Colloidal Reactions on the Cerebrospinal Fluid
    Riddel , D. O., and Stewart, R. M.
  • Spirochaetosis of the Cerebrospinal Fluid
  • The Colloidal Benzoin Reaction of Cerebrospinal Fluid
    Warnock , Fanny