Abstract • We administered diphtheria, tetanus, and pertussis (DTP) vaccine containing acellular (lymphocytosis promoting factor and filamentous hemagglutinin) pertussis vaccine to three groups of 20 children each (4 to 6 years, 17 to 21 months, and 5 to 9 months of age). All the children tolerated the vaccine well; no reactions occurred that contraindicated further Immunization. Older children had significantly more local (redness or swelling) and systemic (fever or fretfulness) reactions than younger children. Eighty percent to 90% of the children in the two older age groups had fourfold or greater increases in antibody titers to DTP antigens one month after vaccination. The postvaccine concentrations of antibody to tetanus and diphtheria were greater than 0.01 IU/mL In all children. Serologic responses to lymphocytosis promoting and filamentous hemagglutinin varied with age; significantly more older children than younger children had four-fold or greater increases. Acellular pertussis DTP vaccine was antigenic in young children and was less reactogenic than standard whole cell DTP vaccine according to rates reported in previous studies. (AJDC 1987;141:949-953) References 1. Broome CV, Fraser DW: Pertussis in the United States, 1979: A look at vaccine efficacy . J Infect Dis 1981;144:187-190.Crossref 2. Pertussis: Maryland, 1982 . MMWR 1983; 32:297-300. 3. Pertussis: Washington, 1984 . MMWR 1985;34:390-399. 4. Pertussis: United States, 1982 and 1983 . MMWR 1984;33:573-575. 5. Pertussis surveillance, 1979-1981 . MMWR 1982;31:333-336. 6. Pertussis outbreak: Oklahoma . MMWR 1984;33:2-10. 7. Hinman AR, Koplan JP: Pertussis and pertussis vaccine: Reanalysis of benefits, risks and costs . JAMA 1984;251:3109-3113.Crossref 8. Schoenbaum SC, Weinstein MC, et al: Pertussis vaccine: An analysis of benefits, risks, and costs . N Engl J Med 1979;301:906-911.Crossref 9. 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Pittman M: The concept of pertussis as a toxin mediated disease . Pediatr Infect Dis 1984;3:467-486.Crossref 16. Tuomanen El, Weiss A: Characterization of two adhesins of Bordetella pertussis for human ciliated respiratory epithelial cells . J Infect Dis 1985;152:118-125.Crossref 17. Oda M, Cowell JL, Burstyn DG, et al: Protective activities of the filamentous hemagglutinin and the lymphocytosis-promoting factor of Bordetella pertussis in mice . J Infect Dis 1984;150:823-833.Crossref 18. Munoz JJ, Arai H, Cole RL: Mouse-protecting and histamine-sensitizing activities of pertussigen and fimbrial hemagglutinin from Bordetella pertussis . Infect Immun 1981;32: 243-250. 19. Oda M, Izumiya K, Sato Y, et al: Transplacental and transcolostral immunity to pertussis in a mouse model using acellular pertussis vaccine . J Infect Dis 1983;148:138-145.Crossref 20. Tuomanen El, Hendley JO: Adherence of Bordetella pertussis to human respiratory epithelial cells . 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American Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1987
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