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Clinical and Pathologic Cutaneous Manifestations of Malignant Histiocytosis

Clinical and Pathologic Cutaneous Manifestations of Malignant Histiocytosis Abstract • The clinical and pathologic changes in the skin of five patients with malignant histiocytosis were studied. The clinical signs included papules, nodules, noduloulcers and purpura. The histopathologic changes included exocytosis of inflammatory cells, infiltration of the papillary and reticular dermis with neoplastic histiocytes, and periadnexal and perivascular infiltrates. Phagocytosis of RBCs and nuclear debris by atypical histiocytes was seen in two cases. In one case, the skin lesions were the only initial manifestation of the disease. Skin involvement occurs in about 10% to 15% of all cases of malignant histiocytosis. Hence, it is important to include malignant histiocytosis in the differential diagnosis of patients with such skin lesions, especially when clinical symptoms may be suggestive of this disease. (Arch Dermatol 1983;119:367-372) References 1. Scott RB, Robb-Smith AHT: Histiocytic medullary reticulosis . Lancet 1939;2:194-198.Crossref 2. Rappaport H: Tumors of Hematopoietic System . in Atlas of Tumor Pathology Armed Forces Institute of Pathology, 1966, section 3 , pt (8) . 3. Vilpo JA, Klemi P, Lassila O, et al: Cytological and functional characterization of three cases of malignant histiocytosis . Cancer 1980;46:1795-1801.Crossref 4. Abele DC, Griffin TB: Histiocytic medullary reticulosis . Arch Dermatol 1972;106:319-329.Crossref 5. Serck-Hanssen A, Purchit GP: Histiocytic medullary reticulosis: Report of 14 cases from Uganda . Br J Cancer 1968;22:506-516.Crossref 6. Kojiro M, Isomura T, Ohtsu N, et al: Atypical malignant lymphoma . Arch Pathol Lab Med 1981;105:317-321. 7. Alexander M, Daniels JR: Chemotherapy of malignant histiocytosis in adults . Cancer 1977;39:1011-1017.Crossref 8. Ho FCS, Todd D: Malignant histiocytosis . Cancer 1978; 42:2450-2460.Crossref 9. Rilke F, Carbone A, Musumeci R, et al: Malignant histiocytosis: A clinicopathologic study of 18 consecutive cases . Tumori 1978;64:211-227. 10. Marshall ME, Farmer ER, Trump DL: Cutaneous involvement in malignant histiocytosis . Arch Dermatol 1981;117:278-281.Crossref 11. Warnke RA, Kim H, Dorfman RF: Malignant histiocytosis (histiocytic medullary reticulosis): Clinicopathologic study of 29 cases . Cancer 1975;35:215-230.Crossref 12. Byrne GE, Rappaport H: Malignant histiocytosis , in Alcazaki K, Rappaport H, Berard CW, et al: (eds): Malignant Diseases of the Hematopoietic System , Gann Monograph on Cancer Research. Tokyo, University of Tokyo Press, 1973, vol 15, pp 145-162. 13. Zucker JM, Caillaux JM, Vanel D, et al: Malignant histiocytosis in childhood . Cancer 1980;45:2821-2829.Crossref 14. Engstrom PF, Aeling JL, Suringa DWR: Histiocytic medullary reticulosis with subcutaneous lesions . Arch Dermatol 1972; 106:369-371.Crossref 15. Friedman RM, Steigbegel NH: Histiocytic medullary reticulosis . Am J Med 1965;38:130-133.Crossref 16. Natelson EA, Lynch EC, Hettig RA, et al: Histiocytic medullary reticulosis: The role of phagocytosis in pancytopenia . Arch Intern Med 1968;122:223-229.Crossref 17. Israels MCG: The reticulosis: A clinicopathologic study . Lancet 1953;265:525-530.Crossref 18. Civin H, Gotschalk HC, Okazaki K: Histiocytic medullary reticulosis: Report of two cases . Arch Intern Med 1953;94:375-383.Crossref 19. Freeman MJ, Taylor JS, Levin HS, et al: Histiocytic medullary reticulosis presenting as Mucha-Habermann disease . Acta Derm Venereol 1978;58:57-64. 20. Cazal P: Aspects cliniques et hematologiques de la reticulose maligne . Acta Haematol 1952;7:65-85.Crossref 21. Olsen T: Histiocytic medullary reticulosis: A postmortem finding in a patient with erythroleukemia and skin carcinomata . Med J Aust 1973;1:242-245. 22. Liao KT, Rosai J, Daneshbod K: Malignant histiocytosis with cutaneous involvement and eosinophilia . Am J Clin Pathol 1972;57:438-448. 23. Rabinowitz BN, Noguchi S, Bergfeld WF: Tumor cell characterization of histiocytic medullary reticulosis . Arch Dermatol 1977;113:927-929.Crossref 24. Huhn D, Meister P: Malignant histiocytosis: Morphologic and cytochemical findings . Cancer 1978;42:1341-1349.Crossref 25. Tubbs RR, Sheibani K, Sebek BA, et al: Malignant histiocytosis . Arch Pathol Lab Med 1980;104:26-29. 26. Rausch PG, Herion JC, Carney CN, et al: Malignant histiocytosis . Cancer 1979;44:2158-2164.Crossref 27. Harousseau JL, Degos L, Daniel MT, et al: Leukemic phase of malignant histiocytosis (arguments in favour of the histiomonocytic origin of the abnormal cells) . Med Pediatr Oncol 1979;6:339-346.Crossref 28. Hidvegi DF, Alonso-Nunez C: Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation . Acta Cytol 1979;23:402-407. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Clinical and Pathologic Cutaneous Manifestations of Malignant Histiocytosis

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650290007007
Publisher site
See Article on Publisher Site

Abstract

Abstract • The clinical and pathologic changes in the skin of five patients with malignant histiocytosis were studied. The clinical signs included papules, nodules, noduloulcers and purpura. The histopathologic changes included exocytosis of inflammatory cells, infiltration of the papillary and reticular dermis with neoplastic histiocytes, and periadnexal and perivascular infiltrates. Phagocytosis of RBCs and nuclear debris by atypical histiocytes was seen in two cases. In one case, the skin lesions were the only initial manifestation of the disease. Skin involvement occurs in about 10% to 15% of all cases of malignant histiocytosis. Hence, it is important to include malignant histiocytosis in the differential diagnosis of patients with such skin lesions, especially when clinical symptoms may be suggestive of this disease. (Arch Dermatol 1983;119:367-372) References 1. Scott RB, Robb-Smith AHT: Histiocytic medullary reticulosis . Lancet 1939;2:194-198.Crossref 2. Rappaport H: Tumors of Hematopoietic System . in Atlas of Tumor Pathology Armed Forces Institute of Pathology, 1966, section 3 , pt (8) . 3. Vilpo JA, Klemi P, Lassila O, et al: Cytological and functional characterization of three cases of malignant histiocytosis . Cancer 1980;46:1795-1801.Crossref 4. Abele DC, Griffin TB: Histiocytic medullary reticulosis . Arch Dermatol 1972;106:319-329.Crossref 5. Serck-Hanssen A, Purchit GP: Histiocytic medullary reticulosis: Report of 14 cases from Uganda . Br J Cancer 1968;22:506-516.Crossref 6. Kojiro M, Isomura T, Ohtsu N, et al: Atypical malignant lymphoma . Arch Pathol Lab Med 1981;105:317-321. 7. Alexander M, Daniels JR: Chemotherapy of malignant histiocytosis in adults . Cancer 1977;39:1011-1017.Crossref 8. Ho FCS, Todd D: Malignant histiocytosis . Cancer 1978; 42:2450-2460.Crossref 9. Rilke F, Carbone A, Musumeci R, et al: Malignant histiocytosis: A clinicopathologic study of 18 consecutive cases . Tumori 1978;64:211-227. 10. Marshall ME, Farmer ER, Trump DL: Cutaneous involvement in malignant histiocytosis . Arch Dermatol 1981;117:278-281.Crossref 11. Warnke RA, Kim H, Dorfman RF: Malignant histiocytosis (histiocytic medullary reticulosis): Clinicopathologic study of 29 cases . Cancer 1975;35:215-230.Crossref 12. Byrne GE, Rappaport H: Malignant histiocytosis , in Alcazaki K, Rappaport H, Berard CW, et al: (eds): Malignant Diseases of the Hematopoietic System , Gann Monograph on Cancer Research. Tokyo, University of Tokyo Press, 1973, vol 15, pp 145-162. 13. Zucker JM, Caillaux JM, Vanel D, et al: Malignant histiocytosis in childhood . Cancer 1980;45:2821-2829.Crossref 14. Engstrom PF, Aeling JL, Suringa DWR: Histiocytic medullary reticulosis with subcutaneous lesions . Arch Dermatol 1972; 106:369-371.Crossref 15. Friedman RM, Steigbegel NH: Histiocytic medullary reticulosis . Am J Med 1965;38:130-133.Crossref 16. Natelson EA, Lynch EC, Hettig RA, et al: Histiocytic medullary reticulosis: The role of phagocytosis in pancytopenia . Arch Intern Med 1968;122:223-229.Crossref 17. Israels MCG: The reticulosis: A clinicopathologic study . Lancet 1953;265:525-530.Crossref 18. Civin H, Gotschalk HC, Okazaki K: Histiocytic medullary reticulosis: Report of two cases . Arch Intern Med 1953;94:375-383.Crossref 19. Freeman MJ, Taylor JS, Levin HS, et al: Histiocytic medullary reticulosis presenting as Mucha-Habermann disease . Acta Derm Venereol 1978;58:57-64. 20. Cazal P: Aspects cliniques et hematologiques de la reticulose maligne . Acta Haematol 1952;7:65-85.Crossref 21. Olsen T: Histiocytic medullary reticulosis: A postmortem finding in a patient with erythroleukemia and skin carcinomata . Med J Aust 1973;1:242-245. 22. Liao KT, Rosai J, Daneshbod K: Malignant histiocytosis with cutaneous involvement and eosinophilia . Am J Clin Pathol 1972;57:438-448. 23. Rabinowitz BN, Noguchi S, Bergfeld WF: Tumor cell characterization of histiocytic medullary reticulosis . Arch Dermatol 1977;113:927-929.Crossref 24. Huhn D, Meister P: Malignant histiocytosis: Morphologic and cytochemical findings . Cancer 1978;42:1341-1349.Crossref 25. Tubbs RR, Sheibani K, Sebek BA, et al: Malignant histiocytosis . Arch Pathol Lab Med 1980;104:26-29. 26. Rausch PG, Herion JC, Carney CN, et al: Malignant histiocytosis . Cancer 1979;44:2158-2164.Crossref 27. Harousseau JL, Degos L, Daniel MT, et al: Leukemic phase of malignant histiocytosis (arguments in favour of the histiomonocytic origin of the abnormal cells) . Med Pediatr Oncol 1979;6:339-346.Crossref 28. Hidvegi DF, Alonso-Nunez C: Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation . Acta Cytol 1979;23:402-407.

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1983

References