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Circulating Antibody Formation in Lupus Erythematosus

Circulating Antibody Formation in Lupus Erythematosus Abstract Quantitative and qualitative changes in the serum proteins are frequently found in both systemic and chronic discoid forms of lupus erythematosus (Lee and Davis, 1959; Cohen and Cadman, 1953), and systemic lupus erythematosus is specifically associated with antinuclear antibodies which play an important part in L.E. cell formation (Miescher et al., 1953). However, Miescher et al. (1960) have shown that the antinuclear immune reactions are not primarily responsible for the disease process and postulate that these are reflections of a general hyperactivity of the antibody-forming system of the body. This paper describes an attempt to measure the antibody-forming activity in lupus erythematosus under controlled conditions. Method Antibody-forming ability was assessed in terms of response to primary immunization with tetanus toxoid. The method has been widely used to study immune responses in various conditions (Greenwood et al., 1958; Cherrick et al., 1959; Wilkens and Tasman, 1959; Greenwood and Barr, 1960), and References 1. Cherrick, G. R.; Pothier, L.; Dufour, J.-J., and Sherlock, S.: New Engl. J. Med. 261:340, 1959.Crossref 2. Cohen, H., and Cadman, E. F. B.: Lancet 2:305, 1953. 3. Glenny, A. T., and Stevens, M. F.: J. Roy. Army Med. Corps 70:308, 1938. 4. Gold, S. C.: Brit. J. Derm. 72:231, 1960.Crossref 5. Greenwood, R., and Barr, M.: Ann. Phys. Med. 5:258, 1960. 6. Lee, L., and Davis, B. J.: A Mount Sinai Hospital Monograph on Systemic Lupus Erythematosus , New York, Grune & Stratton, Inc., 1959, p. 37. 7. Marten, R. H., and Blackburn, E. K.: A.M.A. Arch. Derm. 73:1, 1956.Crossref 8. Miescher, P.; Fauconnet, M., and Béraud, T.: Exp. Med. Surg. 2:173, 1953. 9. Miescher, P. A.; Thomas, L.; Benacerraf, B.; Cooper, N. S.; Franklin, E., and Rothfield, N.: Brit. J. Derm. 72:221, 1960.Crossref 10. Wilkens, G. L., and Tasman, A.: Brit. Med. J. 1:1305, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Circulating Antibody Formation in Lupus Erythematosus

Archives of Dermatology , Volume 84 (3) – Sep 1, 1961

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580150018002
Publisher site
See Article on Publisher Site

Abstract

Abstract Quantitative and qualitative changes in the serum proteins are frequently found in both systemic and chronic discoid forms of lupus erythematosus (Lee and Davis, 1959; Cohen and Cadman, 1953), and systemic lupus erythematosus is specifically associated with antinuclear antibodies which play an important part in L.E. cell formation (Miescher et al., 1953). However, Miescher et al. (1960) have shown that the antinuclear immune reactions are not primarily responsible for the disease process and postulate that these are reflections of a general hyperactivity of the antibody-forming system of the body. This paper describes an attempt to measure the antibody-forming activity in lupus erythematosus under controlled conditions. Method Antibody-forming ability was assessed in terms of response to primary immunization with tetanus toxoid. The method has been widely used to study immune responses in various conditions (Greenwood et al., 1958; Cherrick et al., 1959; Wilkens and Tasman, 1959; Greenwood and Barr, 1960), and References 1. Cherrick, G. R.; Pothier, L.; Dufour, J.-J., and Sherlock, S.: New Engl. J. Med. 261:340, 1959.Crossref 2. Cohen, H., and Cadman, E. F. B.: Lancet 2:305, 1953. 3. Glenny, A. T., and Stevens, M. F.: J. Roy. Army Med. Corps 70:308, 1938. 4. Gold, S. C.: Brit. J. Derm. 72:231, 1960.Crossref 5. Greenwood, R., and Barr, M.: Ann. Phys. Med. 5:258, 1960. 6. Lee, L., and Davis, B. J.: A Mount Sinai Hospital Monograph on Systemic Lupus Erythematosus , New York, Grune & Stratton, Inc., 1959, p. 37. 7. Marten, R. H., and Blackburn, E. K.: A.M.A. Arch. Derm. 73:1, 1956.Crossref 8. Miescher, P.; Fauconnet, M., and Béraud, T.: Exp. Med. Surg. 2:173, 1953. 9. Miescher, P. A.; Thomas, L.; Benacerraf, B.; Cooper, N. S.; Franklin, E., and Rothfield, N.: Brit. J. Derm. 72:221, 1960.Crossref 10. Wilkens, G. L., and Tasman, A.: Brit. Med. J. 1:1305, 1959.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1961

References