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Cimetidine in Scleroderma

Cimetidine in Scleroderma Abstract To the Editor.— We have been using cimetidine in a 55-year-old man with systemic scleroderma of the acrosclerosis type to control symptoms of reflux esophagitis, including substernal pain on recumbency and postprandially, especially prominent on retiring in the evening.Evaluation of the esophagus with fluoroscopy showed a small hiatal hernia, no noticeable reflux, and normal motility. The stomach, duodenal loop, and small bowel appeared normal. The result of the large bowel series also was considered normal.Endoscopy demonstrated a nodular appearance at the distal area of the esophagus. Biopsy specimens were taken from the area to rule out carcinomatous changes; the results were negative.Esophageal motility studies showed normal upper esophageal sphincter and pharyngeal muscle contractions of the distal two thirds of the esophageal body and multiple low-amplitude simultaneous contractions. The lower esophageal sphincter pressure was 9 mm Hg (normal, 15 to 30 mm Hg).The patient was given cimetidine, References 1. Spiro HM, Dobbins J, Levine RA, et al: Cimetidine, antacids, or both: What's the best choice now? Curr Prescribing 4:39-49, 1978. 2. Finkelstein W, Isselbacher KJ: Drug therapy: Cimetidine . N Engl J Med 299:992-996, 1978.Crossref 3. Longstreth GF, Go VL, Malageladam JR: Cimetidine suppression of nocturnal gastric secretion in acute duodenal ulcer . N Engl J Med 294:801-804, 1976.Crossref 4. Jones RH: Cimetidine: Prophylaxis against upper gastrointestinal hemorrhage after renal transplantation . Br Med J 1:398-400, 1978.Crossref 5. Bahar J: Cimetidine in the treatment of symptomatic gastroesophageal reflux . Gastroenterol 74:441-448, 1978. 6. Castell DO: Sense with cimetidine . JAMA 240:564, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cimetidine in Scleroderma

Abstract

Abstract To the Editor.— We have been using cimetidine in a 55-year-old man with systemic scleroderma of the acrosclerosis type to control symptoms of reflux esophagitis, including substernal pain on recumbency and postprandially, especially prominent on retiring in the evening.Evaluation of the esophagus with fluoroscopy showed a small hiatal hernia, no noticeable reflux, and normal motility. The stomach, duodenal loop, and small bowel appeared normal. The result of the large bowel...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010090004010
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— We have been using cimetidine in a 55-year-old man with systemic scleroderma of the acrosclerosis type to control symptoms of reflux esophagitis, including substernal pain on recumbency and postprandially, especially prominent on retiring in the evening.Evaluation of the esophagus with fluoroscopy showed a small hiatal hernia, no noticeable reflux, and normal motility. The stomach, duodenal loop, and small bowel appeared normal. The result of the large bowel series also was considered normal.Endoscopy demonstrated a nodular appearance at the distal area of the esophagus. Biopsy specimens were taken from the area to rule out carcinomatous changes; the results were negative.Esophageal motility studies showed normal upper esophageal sphincter and pharyngeal muscle contractions of the distal two thirds of the esophageal body and multiple low-amplitude simultaneous contractions. The lower esophageal sphincter pressure was 9 mm Hg (normal, 15 to 30 mm Hg).The patient was given cimetidine, References 1. Spiro HM, Dobbins J, Levine RA, et al: Cimetidine, antacids, or both: What's the best choice now? Curr Prescribing 4:39-49, 1978. 2. Finkelstein W, Isselbacher KJ: Drug therapy: Cimetidine . N Engl J Med 299:992-996, 1978.Crossref 3. Longstreth GF, Go VL, Malageladam JR: Cimetidine suppression of nocturnal gastric secretion in acute duodenal ulcer . N Engl J Med 294:801-804, 1976.Crossref 4. Jones RH: Cimetidine: Prophylaxis against upper gastrointestinal hemorrhage after renal transplantation . Br Med J 1:398-400, 1978.Crossref 5. Bahar J: Cimetidine in the treatment of symptomatic gastroesophageal reflux . Gastroenterol 74:441-448, 1978. 6. Castell DO: Sense with cimetidine . JAMA 240:564, 1978.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1979

References