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Cigarette Smoking and the Incidence of Breast Cancer

Cigarette Smoking and the Incidence of Breast Cancer ORIGINAL INVESTIGATION Cigarette Smoking and the Incidence of Breast Cancer Fei Xue, MD, ScD; Walter C. Willett, MD, DrPH; Bernard A. Rosner, PhD; Susan E. Hankinson, ScD; Karin B. Michels, ScD, PhD Background: Tobacco smoke contains carcinogens, trend=.003) smoking, younger age at smoking initia- which may increase the risk of breast cancer (BC). Con- tion (P for trend=.01), longer duration of smoking (P for versely, cigarette smoking also has antiestrogenic ef- trend=.01), and more pack-years of smoking (P for fects, which may reduce the risk of BC. The association trend=.005). Premenopausal smoking was associated with between smoking and BC remains controversial. a slightly higher incidence of BC (HR,1.11; 95% CI, 1.07- 1.15 for every increase of 20 pack-years), especially smok- Methods: Prospective cohort study of 111 140 partici- ing before first birth (1.18; 1.10-1.27 for every increase pants of the Nurses’ Health Study from 1976 to 2006 for of 20 pack-years). Conversely, the direction of the asso- active smoking and 36 017 women from 1982 to 2006 ciation between postmenopausal smoking and BC was for passive smoking. inverse (0.93; 0.85-1.02 for every increase of 20 pack- years). Passive smoking in childhood or adulthood was Results: During 3 005 863 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Cigarette Smoking and the Incidence of Breast Cancer

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References (78)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2010.503
pmid
21263102
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Cigarette Smoking and the Incidence of Breast Cancer Fei Xue, MD, ScD; Walter C. Willett, MD, DrPH; Bernard A. Rosner, PhD; Susan E. Hankinson, ScD; Karin B. Michels, ScD, PhD Background: Tobacco smoke contains carcinogens, trend=.003) smoking, younger age at smoking initia- which may increase the risk of breast cancer (BC). Con- tion (P for trend=.01), longer duration of smoking (P for versely, cigarette smoking also has antiestrogenic ef- trend=.01), and more pack-years of smoking (P for fects, which may reduce the risk of BC. The association trend=.005). Premenopausal smoking was associated with between smoking and BC remains controversial. a slightly higher incidence of BC (HR,1.11; 95% CI, 1.07- 1.15 for every increase of 20 pack-years), especially smok- Methods: Prospective cohort study of 111 140 partici- ing before first birth (1.18; 1.10-1.27 for every increase pants of the Nurses’ Health Study from 1976 to 2006 for of 20 pack-years). Conversely, the direction of the asso- active smoking and 36 017 women from 1982 to 2006 ciation between postmenopausal smoking and BC was for passive smoking. inverse (0.93; 0.85-1.02 for every increase of 20 pack- years). Passive smoking in childhood or adulthood was Results: During 3 005 863

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jan 24, 2011

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