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CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA: A Clinical and Neuropathologic Report

CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA: A Clinical and Neuropathologic Report Abstract THERE is a disease of man which is most typically manifested as a gradually progressive weakness of the muscles of the eyelids and of the external muscles of the eyeballs. The disease begins insidiously in early life (before the age of 30) and gradually involves more and more of these muscles until finally, after many years (30 to 40), severe ptosis and external ophthalmoplegia are present. The process may be bilateral or unilateral; it may be asymmetric in degree of involvement; progress of the disease may stop temporarily or permanently at any point, but remissions do not occur; the pupils remain unaffected; family incidence has been noted, and other muscles of the face, limbs, or trunk may show a similar kind of progressive weakness and wasting. The literature on this disease has recently been summarized by Kiloh and Nevin,1 and it is they who have furnished a full and References 1. References 2, 3, and 4. 2. References 2, 3, and 4. 3. References 24, 25 and 26. 4. References 2 and 3. 5. Kiloh, L. G., and Nevin, S.: Progressive Dystrophy of the External Ocular Muscles (Ocular Myopathy) , Brain 74:115-143, 1951.Crossref 6. Langdon, H. M., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia: Report of Case with Necropsy , Tr. Am. Ophth. Soc. 26:247, 1928. 7. Langdon, H. M., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia: Report of Case with Necropsy , Brain 51:321-333, 1928.Crossref 8. Jedlowski, P.: Sulla oftalmoplegia esterna nucleare cronica progressiva , Riv.-oto-neurooftal. 20:203-239, 1943. 9. Gartner, S., and Billet, E.: Progressive Muscular Dystrophy Involving the Extraocular Muscles; Report of Case , Arch. Ophth. 41:334-340, 1949.Crossref 10. Beckett, R. S., and Netsky, M. G.: Familial Ocular Myopathy and External Ophthalmoplegia , A. M. A. Arch. Neurol. & Psychiat. 69:64-72, 1953. 11. Durante, G.: Anatomie pathologique des muscles , in Cornil, V., and Ranvier, L.: Manuel d'histologie pathologique , Paris, Felix Alcan, Vol. 2, 1902, pp. 1-477. 12. Slauck, A.: Die pathologische Anatomie der Myopathien , in Bumke, O., and Foerster, O.: Handbuch der Neurologie , Berlin, Springer-Verlag, Vol. 16, 1932, pp. 412-431. 13. Hassin, G. B.: Histopathology of Progressive Muscular Dystrophy , J. Neuropath. & Exper. Neurol. 2:315-325, 1943. 14. Bowden, R. E. M., and Gutmann, E.: Observations in a Case of Muscular Dystrophy, with Reference to Diagnostic Significance , Arch. Neurol. & Psychiat. 56:1-19, 1946. 15. Falin, L. I., and Kanarejkin, K. F.: Histopathologie der motorischen Nervendigungen bei Myopathie und einigen verwandten Erkrankungen , Arch. path. Anat. 307:523-540, 1941. 16. Kirschbaum, W. R.: Histological Studies of Muscle Tissue in Neuromuscular Diseases , J. Neuropath. & Exper. Neurol. 11:373-391, 1952. 17. Arieff, A. J., and Kirschbaum, W. R.: Clinical, Histologic and Electrical Studies in Muscular Dystrophies , Neurology 3:35-43, 1953. 18. Batten, F. E.: The Muscle-Spindle Under Pathological Conditions , Brain 20:138-179, 1897. 19. Spiller, W. G.: The Neuromuscular Bundles (Muskel-Knospen, Muskelspindeln, Faisceaux Neuro-Musculaires) , J. Nerv. & Ment. Dis. 24:626-630, 1897. 20. Bruce, A. N.: The Muscle Spindles in Pseudohypertrophic Paralysis , Rev. Neurol. & Psychiat. 9:110-114, 1911. 21. Cogan, D. G.: Neurology of the Ocular Muscles , Springfield, Ill., Charles C Thomas, Publisher, 1948, pp. 3-6. 22. Cooper, S., and Daniel, P. M.: Muscle Spindles in Human Extrinsic Eye Muscles , Brain 72:1-24, 1949. 23. Cilimbaris, P.: Histologische Untersuchungen über die Muskelspindeln der Augenmuskeln , Arch. mikr. Anat. 75:692-747, 1910. 24. Merrillees, N. C. R.; Sunderland, S., and Hayhow, W.: Neuromuscular Spindles in the Extraocular Muscles in Man , Anat. Rec. 108:23-30, 1950. 25. Woollard, H. H.: The Innervation of the Ocular Muscles , J. Anat. 65:215-223, 1931. 26. Daniel, P.: Spiral Nerve Endings in the Extrinsic Eye Muscles of Man , J. Anat. 80: 189-193, 1946. 27. Hirano, N.: Histologische Untersuchungen über die nervöses Innervation der menschlichen äusseren Augenmuskeln , von Graefes Arch. Ophth. 142:560-575, 1941.Crossref 28. Corbin, K. B., and Harrison, F.: Further Attempts to Trace the Origin of Afferent Nerves to the Extrinsic Eye Muscles , J. Comp. Neurol. 77:187-190, 1942.Crossref 29. Corbin, K. B., and Oliver, R. K.: The Origin of Fibers to the Grape-Like Endings in Insertion Third of the Extra-Ocular Muscles , J. Comp. Neurol. 77:171-186, 1942.Crossref 30. Cooper, S.; Daniel, P. M., and Whitteridge, D.: Afferent Impulses in the Oculomotor Nerve, from the Extrinsic Eye Muscles , J. Physiol. 113:463-474, 1951. 31. Tergast, P.: Über das Verhältniss von Nerve und Muskel , Arch. mikr. Anat. 9:36-46, 1873.Crossref 32. Fulton, J. F.: Muscular Contraction and the Reflex Control of Movement , Baltimore, Williams & Wilkins Company, 1926, p. 369. 33. Holmes, G.: On the Spinal Changes in a Case of Muscular Dystrophy , Rev. Neurol. & Psychiat. 6:137-149, 1908. 34. Friesz, J.: Beitrag zus anatomischen Kenntnis der Muskeldystropie , Deutsche Ztschr. Nervenh. 112:318-326, 1930. 35. Spiller, W. G.: Two Cases of Muscular Dystrophy with Necropsy , Tr. Am. Neurol. A . 25:158-160, 1899. 36. Landouzy, L., and Lortat-Jacob, L.: Histoire d'un myopathique atrophique (du type facio-scapulo-huméral) suivi pendant 30 ans , Presse méd. 17:145-149, 1909. 37. Wilson, S. A. K.: Neurology , Baltimore, Williams & Wilkins Company, Vol. 2, 1940, p. 987. 38. Wertham, F., and Wertham, F.: The Brain as an Organ: Its Postmortem Study and Interpretation , New York, The Macmillan Company, 1934, pp. 144 and 266. 39. Sunaga, Y.: Experimentelle und pathologische Studien über die progressive Muskelatrophie: Über die trophische Innervation der äusseren Augenmuskeln , Ztschr. ges. exper. Med. 54:366-381, 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA: A Clinical and Neuropathologic Report

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American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02320370033003
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Abstract

Abstract THERE is a disease of man which is most typically manifested as a gradually progressive weakness of the muscles of the eyelids and of the external muscles of the eyeballs. The disease begins insidiously in early life (before the age of 30) and gradually involves more and more of these muscles until finally, after many years (30 to 40), severe ptosis and external ophthalmoplegia are present. The process may be bilateral or unilateral; it may be asymmetric in degree of involvement; progress of the disease may stop temporarily or permanently at any point, but remissions do not occur; the pupils remain unaffected; family incidence has been noted, and other muscles of the face, limbs, or trunk may show a similar kind of progressive weakness and wasting. The literature on this disease has recently been summarized by Kiloh and Nevin,1 and it is they who have furnished a full and References 1. References 2, 3, and 4. 2. References 2, 3, and 4. 3. References 24, 25 and 26. 4. References 2 and 3. 5. Kiloh, L. G., and Nevin, S.: Progressive Dystrophy of the External Ocular Muscles (Ocular Myopathy) , Brain 74:115-143, 1951.Crossref 6. Langdon, H. M., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia: Report of Case with Necropsy , Tr. Am. Ophth. Soc. 26:247, 1928. 7. Langdon, H. M., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia: Report of Case with Necropsy , Brain 51:321-333, 1928.Crossref 8. Jedlowski, P.: Sulla oftalmoplegia esterna nucleare cronica progressiva , Riv.-oto-neurooftal. 20:203-239, 1943. 9. Gartner, S., and Billet, E.: Progressive Muscular Dystrophy Involving the Extraocular Muscles; Report of Case , Arch. Ophth. 41:334-340, 1949.Crossref 10. Beckett, R. S., and Netsky, M. G.: Familial Ocular Myopathy and External Ophthalmoplegia , A. M. A. Arch. Neurol. & Psychiat. 69:64-72, 1953. 11. Durante, G.: Anatomie pathologique des muscles , in Cornil, V., and Ranvier, L.: Manuel d'histologie pathologique , Paris, Felix Alcan, Vol. 2, 1902, pp. 1-477. 12. Slauck, A.: Die pathologische Anatomie der Myopathien , in Bumke, O., and Foerster, O.: Handbuch der Neurologie , Berlin, Springer-Verlag, Vol. 16, 1932, pp. 412-431. 13. Hassin, G. B.: Histopathology of Progressive Muscular Dystrophy , J. Neuropath. & Exper. Neurol. 2:315-325, 1943. 14. Bowden, R. E. M., and Gutmann, E.: Observations in a Case of Muscular Dystrophy, with Reference to Diagnostic Significance , Arch. Neurol. & Psychiat. 56:1-19, 1946. 15. Falin, L. I., and Kanarejkin, K. F.: Histopathologie der motorischen Nervendigungen bei Myopathie und einigen verwandten Erkrankungen , Arch. path. Anat. 307:523-540, 1941. 16. Kirschbaum, W. R.: Histological Studies of Muscle Tissue in Neuromuscular Diseases , J. Neuropath. & Exper. Neurol. 11:373-391, 1952. 17. Arieff, A. J., and Kirschbaum, W. R.: Clinical, Histologic and Electrical Studies in Muscular Dystrophies , Neurology 3:35-43, 1953. 18. Batten, F. E.: The Muscle-Spindle Under Pathological Conditions , Brain 20:138-179, 1897. 19. Spiller, W. G.: The Neuromuscular Bundles (Muskel-Knospen, Muskelspindeln, Faisceaux Neuro-Musculaires) , J. Nerv. & Ment. Dis. 24:626-630, 1897. 20. Bruce, A. N.: The Muscle Spindles in Pseudohypertrophic Paralysis , Rev. Neurol. & Psychiat. 9:110-114, 1911. 21. Cogan, D. G.: Neurology of the Ocular Muscles , Springfield, Ill., Charles C Thomas, Publisher, 1948, pp. 3-6. 22. Cooper, S., and Daniel, P. M.: Muscle Spindles in Human Extrinsic Eye Muscles , Brain 72:1-24, 1949. 23. Cilimbaris, P.: Histologische Untersuchungen über die Muskelspindeln der Augenmuskeln , Arch. mikr. Anat. 75:692-747, 1910. 24. Merrillees, N. C. R.; Sunderland, S., and Hayhow, W.: Neuromuscular Spindles in the Extraocular Muscles in Man , Anat. Rec. 108:23-30, 1950. 25. Woollard, H. H.: The Innervation of the Ocular Muscles , J. Anat. 65:215-223, 1931. 26. Daniel, P.: Spiral Nerve Endings in the Extrinsic Eye Muscles of Man , J. Anat. 80: 189-193, 1946. 27. Hirano, N.: Histologische Untersuchungen über die nervöses Innervation der menschlichen äusseren Augenmuskeln , von Graefes Arch. Ophth. 142:560-575, 1941.Crossref 28. Corbin, K. B., and Harrison, F.: Further Attempts to Trace the Origin of Afferent Nerves to the Extrinsic Eye Muscles , J. Comp. Neurol. 77:187-190, 1942.Crossref 29. Corbin, K. B., and Oliver, R. K.: The Origin of Fibers to the Grape-Like Endings in Insertion Third of the Extra-Ocular Muscles , J. Comp. Neurol. 77:171-186, 1942.Crossref 30. Cooper, S.; Daniel, P. M., and Whitteridge, D.: Afferent Impulses in the Oculomotor Nerve, from the Extrinsic Eye Muscles , J. Physiol. 113:463-474, 1951. 31. Tergast, P.: Über das Verhältniss von Nerve und Muskel , Arch. mikr. Anat. 9:36-46, 1873.Crossref 32. Fulton, J. F.: Muscular Contraction and the Reflex Control of Movement , Baltimore, Williams & Wilkins Company, 1926, p. 369. 33. Holmes, G.: On the Spinal Changes in a Case of Muscular Dystrophy , Rev. Neurol. & Psychiat. 6:137-149, 1908. 34. Friesz, J.: Beitrag zus anatomischen Kenntnis der Muskeldystropie , Deutsche Ztschr. Nervenh. 112:318-326, 1930. 35. Spiller, W. G.: Two Cases of Muscular Dystrophy with Necropsy , Tr. Am. Neurol. A . 25:158-160, 1899. 36. Landouzy, L., and Lortat-Jacob, L.: Histoire d'un myopathique atrophique (du type facio-scapulo-huméral) suivi pendant 30 ans , Presse méd. 17:145-149, 1909. 37. Wilson, S. A. K.: Neurology , Baltimore, Williams & Wilkins Company, Vol. 2, 1940, p. 987. 38. Wertham, F., and Wertham, F.: The Brain as an Organ: Its Postmortem Study and Interpretation , New York, The Macmillan Company, 1934, pp. 144 and 266. 39. Sunaga, Y.: Experimentelle und pathologische Studien über die progressive Muskelatrophie: Über die trophische Innervation der äusseren Augenmuskeln , Ztschr. ges. exper. Med. 54:366-381, 1927.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jan 1, 1954

References