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Chronic Myelocytic Leukemia and Identical Twins: Additional Evidence of the Philadelphia Chromosome as Postzygotic Abnormality

Chronic Myelocytic Leukemia and Identical Twins: Additional Evidence of the Philadelphia... Abstract IN 1960, Nowell and Hungerford demonstrated an abnormal chromosomal marker in chronic myelocytic leukemia (CML).1 This observation has been confirmed2-8 and the abnormal chromosome has been named Philadelphia or Ph1 chromosome.3 The mechanism of its production may be analogous to the production of a smaller G choromosome found in patients accidentally exposed to total-body irradiation.9 If so, it would indicate that the Ph1 chromosome is an acquired abnormality rather than a prezygotic abnormality. This postulation was supported by our finding that there was no Ph1 chromosome in a normal identical twin whose leukemic twin showed typical Ph1 chromosome.10 This communication reports the clinical and cytogenetic findings in another set of identical twins, one having CML; it also reports follow-up studies of the surviving normal identical twin of our first reported set10 7½ years after the diagnosis of CML in his References 1. Nowell, P.C., and Hungerford, D.A.: A Minute Chromosome in Human Chronic Granulocytic Leukemia , Science 132:1497, 1960. 2. Baikie, A.G., et al: A Possible Specific Chromosome Abnormality in Human Chronic Myeloid Leukaemia , Nature 188:1165-1166, 1960.Crossref 3. Tough, I.M., et al: Cytogenetic Studies in Chronic Myeloid Leukaemia and Acute Leukaemia Associated With Mongolism , Lancet 1:411-417, 1961.Crossref 4. Nowell, P.C., and Hungerford, D.A.: Chromosome Studies in Human Leukemia: II. Chronic Granulocytic Leukemia , J Nat Cancer Inst 27:1013-1035, 1961. 5. Sandberg, A.A., et al: Comparison of Chromosome Constitution in Chronic Myelocytic Leukemia and Other Myeloproliferative Disorders , Blood 20: 393-423, 1962. 6. Fitzgerald, P.H., Adams, A.; and Gunz, F.W.: Chronic Granulocytic Leukemia and the Philadelphia Chromosome , Blood 21:183-196, 1963. 7. Whang, J., et al: The Distribution of the Philadelphia Chromosome in Patients With Chronic Myelogenous Leukemia , Blood 22:664-673, 1963. 8. Goh, K.O., and Swisher, S.N.: Specificity of the Philadelphia Chromosome: Cytogenic Studies in Cases of Chronic Myelocytic Leukemia and Myeloid Metaplasia , Ann Intern Med 61:609-624, 1964.Crossref 9. Goh, K.O.: Smaller G Chromosome in Irradiated Man , Lancet 1:659-660, 1966.Crossref 10. Goh, K.O., and Swisher, S.N.: Identical Twins and Chronic Myelocytic Leukemia: Chromosomal Studies of a Patient With Chronic Myelocytic Leukemia and His Normal Identical Twin , Arch Intern Med 115:475-478, 1965.Crossref 11. Hungerford, D.A., et al: The Chromosome Constitution of Human Phenotypic Intersex , Amer J Hum Genet 11:215-236, 1959. 12. Tjio, J.H., and Whang, J.: Chromosome Preparations of Bone Marrow Cells Without Prior in Vitro Culture or in Vivo Colchicine Administration , Stain Tech 37:17-20, 1962. 13. Goh, K.O.: Human Cytogenetics: An Approach to Clinical and Experimental Medicine , Disease-a-Month Monograph Series, Chicago: Year Book Medical Publishers, Inc, April 1965, pp 47. 14. Gunz, F.W.; Fitzgerald, P.H.; and Adams, A.: An Abnormal Chromosome in Chronic Lymphocytic Leukaemia , Brit Med J 2:1097-1099, 1962.Crossref 15. Court-Brown, W.M.: Chromosomal Abnormality and Chronic Lymphatic Leukaemia , Lancet 1: 986, 1964.Crossref 16. Fitzgerald, P.H., and Gunz, F.W.: Chromosomal Abnormality and Chronic Lymphocytic Leukaemia , Lancet 2:150, 1964.Crossref 17. Jacobs, E.M.; Luce, J.K.; and Caillean, R.: Chromosomal Abnormalities in Human Cancer: Report of a Patient With Chronic Myelocytic Leukemia and His Nonleukemic Monozygotic Twin , Cancer 19:869-876. 1966.Crossref 18. Woodliff, H.J.; Dougan, L.; and Onesti, P.: Cytogenetic Studies in Twins, One of Whom has Chronic Granulocytic Leukaemia, abstracted , Nature 211:533, 1966.Crossref 19. Weiner, L.: A Family With High Incidence of Leukemia and Unique Ph1 Chromosome Finding, abstracted , Blood 26:871, 1965. 20. Sandberg, A.A.; Kikuchi, Y.; and Crosswhite, L.H.: Mitotic Activity of Leukocytes in Chronic Myelocytic Leukemia , Cancer Res 24:1468-1473, 1964. 21. Goh, K.O.: Studies of Lymphocytes From Patients With Chronic Myelocytic Leukemia, abstracted , Clin Res 12:449, 1964. 22. Speed, D.E., and Lawler, S.D.: Chronic Granulocytic Leukaemia: The Chromosomes and the Disease , Lancet 1:403-408, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Chronic Myelocytic Leukemia and Identical Twins: Additional Evidence of the Philadelphia Chromosome as Postzygotic Abnormality

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00300020086011
Publisher site
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Abstract

Abstract IN 1960, Nowell and Hungerford demonstrated an abnormal chromosomal marker in chronic myelocytic leukemia (CML).1 This observation has been confirmed2-8 and the abnormal chromosome has been named Philadelphia or Ph1 chromosome.3 The mechanism of its production may be analogous to the production of a smaller G choromosome found in patients accidentally exposed to total-body irradiation.9 If so, it would indicate that the Ph1 chromosome is an acquired abnormality rather than a prezygotic abnormality. This postulation was supported by our finding that there was no Ph1 chromosome in a normal identical twin whose leukemic twin showed typical Ph1 chromosome.10 This communication reports the clinical and cytogenetic findings in another set of identical twins, one having CML; it also reports follow-up studies of the surviving normal identical twin of our first reported set10 7½ years after the diagnosis of CML in his References 1. Nowell, P.C., and Hungerford, D.A.: A Minute Chromosome in Human Chronic Granulocytic Leukemia , Science 132:1497, 1960. 2. Baikie, A.G., et al: A Possible Specific Chromosome Abnormality in Human Chronic Myeloid Leukaemia , Nature 188:1165-1166, 1960.Crossref 3. Tough, I.M., et al: Cytogenetic Studies in Chronic Myeloid Leukaemia and Acute Leukaemia Associated With Mongolism , Lancet 1:411-417, 1961.Crossref 4. Nowell, P.C., and Hungerford, D.A.: Chromosome Studies in Human Leukemia: II. Chronic Granulocytic Leukemia , J Nat Cancer Inst 27:1013-1035, 1961. 5. Sandberg, A.A., et al: Comparison of Chromosome Constitution in Chronic Myelocytic Leukemia and Other Myeloproliferative Disorders , Blood 20: 393-423, 1962. 6. Fitzgerald, P.H., Adams, A.; and Gunz, F.W.: Chronic Granulocytic Leukemia and the Philadelphia Chromosome , Blood 21:183-196, 1963. 7. Whang, J., et al: The Distribution of the Philadelphia Chromosome in Patients With Chronic Myelogenous Leukemia , Blood 22:664-673, 1963. 8. Goh, K.O., and Swisher, S.N.: Specificity of the Philadelphia Chromosome: Cytogenic Studies in Cases of Chronic Myelocytic Leukemia and Myeloid Metaplasia , Ann Intern Med 61:609-624, 1964.Crossref 9. Goh, K.O.: Smaller G Chromosome in Irradiated Man , Lancet 1:659-660, 1966.Crossref 10. Goh, K.O., and Swisher, S.N.: Identical Twins and Chronic Myelocytic Leukemia: Chromosomal Studies of a Patient With Chronic Myelocytic Leukemia and His Normal Identical Twin , Arch Intern Med 115:475-478, 1965.Crossref 11. Hungerford, D.A., et al: The Chromosome Constitution of Human Phenotypic Intersex , Amer J Hum Genet 11:215-236, 1959. 12. Tjio, J.H., and Whang, J.: Chromosome Preparations of Bone Marrow Cells Without Prior in Vitro Culture or in Vivo Colchicine Administration , Stain Tech 37:17-20, 1962. 13. Goh, K.O.: Human Cytogenetics: An Approach to Clinical and Experimental Medicine , Disease-a-Month Monograph Series, Chicago: Year Book Medical Publishers, Inc, April 1965, pp 47. 14. Gunz, F.W.; Fitzgerald, P.H.; and Adams, A.: An Abnormal Chromosome in Chronic Lymphocytic Leukaemia , Brit Med J 2:1097-1099, 1962.Crossref 15. Court-Brown, W.M.: Chromosomal Abnormality and Chronic Lymphatic Leukaemia , Lancet 1: 986, 1964.Crossref 16. Fitzgerald, P.H., and Gunz, F.W.: Chromosomal Abnormality and Chronic Lymphocytic Leukaemia , Lancet 2:150, 1964.Crossref 17. Jacobs, E.M.; Luce, J.K.; and Caillean, R.: Chromosomal Abnormalities in Human Cancer: Report of a Patient With Chronic Myelocytic Leukemia and His Nonleukemic Monozygotic Twin , Cancer 19:869-876. 1966.Crossref 18. Woodliff, H.J.; Dougan, L.; and Onesti, P.: Cytogenetic Studies in Twins, One of Whom has Chronic Granulocytic Leukaemia, abstracted , Nature 211:533, 1966.Crossref 19. Weiner, L.: A Family With High Incidence of Leukemia and Unique Ph1 Chromosome Finding, abstracted , Blood 26:871, 1965. 20. Sandberg, A.A.; Kikuchi, Y.; and Crosswhite, L.H.: Mitotic Activity of Leukocytes in Chronic Myelocytic Leukemia , Cancer Res 24:1468-1473, 1964. 21. Goh, K.O.: Studies of Lymphocytes From Patients With Chronic Myelocytic Leukemia, abstracted , Clin Res 12:449, 1964. 22. Speed, D.E., and Lawler, S.D.: Chronic Granulocytic Leukaemia: The Chromosomes and the Disease , Lancet 1:403-408, 1964.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1967

References