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Chronic Cutaneous Lupus Erythematosus: Thalidomide Treatment of 11 Patients

Chronic Cutaneous Lupus Erythematosus: Thalidomide Treatment of 11 Patients Abstract • Eleven patients with severe, chloroquine-resistant chronic cutaneous lupus erythematosus were treated with oral thalidomide. Seven patients responded with a complete remission, and two patients' conditions improved significantly. One patient did not respond well to therapy and another patient had to be withdrawn from the treatment trial because of side effects. Six patients, who relapsed after discontinuing thalidomide treatment, were re-treated with maintenance drug dosages and achieved good results with no further relapses or exacerbations. In all subjects the side effects from the thalidomide were minor and reversible. (Arch Dermatol 1983;119:812-815) References 1. Sheskin J: The treatment of lepra reaction in lepromatous leprosy: Fifteen years' experience with thalidomide . Int J Dermatol 1980;19:318-322.Crossref 2. Barba Rubio J, Franco González F: Lupus eritematoso discoide y talidomida . Dermatol Rev Mex 1975;19:131-139. 3. Sontheimer RD, Thomas JR, Gilliam JN: Subacute cutaneous lupus erythematosus: A cutaneous marker for a distinct lupus erythematosus subset . Arch Dermatol 1979;115:1409-1415.Crossref 4. Samsoen M, Grosshans E, Basset A: La thalidomide dans le traitement du lupus érythémateux chronique (LEC) . Ann Dermatol Venereol 1980;107:515-522. 5. Knop J, Happle R, Bonsmann G, et al: Treatment of chronic discoid lupus erythematosus with thalidomide . Arch Dermatol Res 1981;271:165-170.Crossref 6. Hasper MF, Klokke AH: Thalidomide in the treatment of chronic discoid lupus erythematosus . Acta Derm Venereol 1982;62:321-324. 7. Levy L, Fasal P, Levan NE, et al: Treatment of erythema nodosum leprosum with thalidomide . Lancet 1973;2:324-325.Crossref 8. Eravelly J, Waters MFR: Thalidomide in Weber-Christian disease . Lancet 1977;1:251.Crossref 9. Calnan CD, Meara RH: Actinic prurigo (Hutchinson's summer prurigo) . Clin Exp Dermatol 1977;2:365-372.Crossref 10. Londono F: Thalidomide in the treatment of actinic prurigo . Int J Dermatol 1973;12:326-328.Crossref 11. Londono F: Studies of the mechanism of action of thalidomide in chronic polymorphic light eruption . Read before the Fourth World Congress of the International Society of Tropical Dermatology, New Orleans, Sept 23-27, 1979. 12. Sheskin J: Zur Therapie des Prurigo Nodularis Hyde mit Thalidomid . Hautarzt 1975;26:215-217. 13. Van den Broek H: Treatment of prurigo nodularis with thalidomide . Arch Dermatol 1980;116:571-572.Crossref 14. Mascaro JM, Lecha M, Torras H: Thalidomide in the treatment of recurrent necrotic and giant mucocutaneous aphthae and aphthosis . Arch Dermatol 1979;115:636-637.Crossref 15. Knop J, Happle R, Vakilzadeh F, et al: Treatment of lupus erythematosus profundus with thalidomide . Arch Dermatol Res 1981;270:229. 16. Gusdon JP, Cohen C: Effect of thalidomide on the antibody response . Am J Obstet Gynecol 1968;100:952-956. 17. Hellmann K, Duke DI, Tucker DF: Prolongation of skin homograft survival by thalidomide . Br Med J 1965;2:687-689.Crossref 18. Turk JL, Hellmann K, Duke DI: Effect of thalidomide on the immunological response in local lymph nodes after a skin homograft . Lancet 1966;1:1134-1136.Crossref 19. Klüken N, Ventz W: Indications for thalidomide therapy for leprosy . Int J Dermatol 1974;13:20-25.Crossref 20. Hastings RC, Morales MJ, Shannon EJ: Studies on the mechanism of action of thalidomide in leprosy . Pharmacologist 1976;18:218-221. 21. Saläun J: L'action tératogène de la thalidomide . Ann Biol Clin 1968;7:307-326. 22. Roath S, Elves MW, Israels MCG: Effects of thalidomide and its derivates on human leucocytes cultured in vitro . Lancet 1963;1:249-250.Crossref 23. Faure M, Thivolet J, Gaucherand M: Inhibition of PMN leucocytes chemotaxis by thalidomide . Arch Dermatol Res 1980;269:275-280.Crossref 24. Lutwak-Mann C: Observations on progeny of thalidomide-treated male rabbits . Br Med J 1964;1:1090-1091.Crossref 25. Lutwak-Mann C, Schmid K, Keberle H: Thalidomide in rabbit semen . Nature 1967;214:1018-1020.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Chronic Cutaneous Lupus Erythematosus: Thalidomide Treatment of 11 Patients

Archives of Dermatology , Volume 119 (10) – Oct 1, 1983

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650340022013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Eleven patients with severe, chloroquine-resistant chronic cutaneous lupus erythematosus were treated with oral thalidomide. Seven patients responded with a complete remission, and two patients' conditions improved significantly. One patient did not respond well to therapy and another patient had to be withdrawn from the treatment trial because of side effects. Six patients, who relapsed after discontinuing thalidomide treatment, were re-treated with maintenance drug dosages and achieved good results with no further relapses or exacerbations. In all subjects the side effects from the thalidomide were minor and reversible. (Arch Dermatol 1983;119:812-815) References 1. Sheskin J: The treatment of lepra reaction in lepromatous leprosy: Fifteen years' experience with thalidomide . Int J Dermatol 1980;19:318-322.Crossref 2. Barba Rubio J, Franco González F: Lupus eritematoso discoide y talidomida . Dermatol Rev Mex 1975;19:131-139. 3. Sontheimer RD, Thomas JR, Gilliam JN: Subacute cutaneous lupus erythematosus: A cutaneous marker for a distinct lupus erythematosus subset . Arch Dermatol 1979;115:1409-1415.Crossref 4. Samsoen M, Grosshans E, Basset A: La thalidomide dans le traitement du lupus érythémateux chronique (LEC) . Ann Dermatol Venereol 1980;107:515-522. 5. Knop J, Happle R, Bonsmann G, et al: Treatment of chronic discoid lupus erythematosus with thalidomide . Arch Dermatol Res 1981;271:165-170.Crossref 6. Hasper MF, Klokke AH: Thalidomide in the treatment of chronic discoid lupus erythematosus . Acta Derm Venereol 1982;62:321-324. 7. Levy L, Fasal P, Levan NE, et al: Treatment of erythema nodosum leprosum with thalidomide . Lancet 1973;2:324-325.Crossref 8. Eravelly J, Waters MFR: Thalidomide in Weber-Christian disease . Lancet 1977;1:251.Crossref 9. Calnan CD, Meara RH: Actinic prurigo (Hutchinson's summer prurigo) . Clin Exp Dermatol 1977;2:365-372.Crossref 10. Londono F: Thalidomide in the treatment of actinic prurigo . Int J Dermatol 1973;12:326-328.Crossref 11. Londono F: Studies of the mechanism of action of thalidomide in chronic polymorphic light eruption . Read before the Fourth World Congress of the International Society of Tropical Dermatology, New Orleans, Sept 23-27, 1979. 12. Sheskin J: Zur Therapie des Prurigo Nodularis Hyde mit Thalidomid . Hautarzt 1975;26:215-217. 13. Van den Broek H: Treatment of prurigo nodularis with thalidomide . Arch Dermatol 1980;116:571-572.Crossref 14. Mascaro JM, Lecha M, Torras H: Thalidomide in the treatment of recurrent necrotic and giant mucocutaneous aphthae and aphthosis . Arch Dermatol 1979;115:636-637.Crossref 15. Knop J, Happle R, Vakilzadeh F, et al: Treatment of lupus erythematosus profundus with thalidomide . Arch Dermatol Res 1981;270:229. 16. Gusdon JP, Cohen C: Effect of thalidomide on the antibody response . Am J Obstet Gynecol 1968;100:952-956. 17. Hellmann K, Duke DI, Tucker DF: Prolongation of skin homograft survival by thalidomide . Br Med J 1965;2:687-689.Crossref 18. Turk JL, Hellmann K, Duke DI: Effect of thalidomide on the immunological response in local lymph nodes after a skin homograft . Lancet 1966;1:1134-1136.Crossref 19. Klüken N, Ventz W: Indications for thalidomide therapy for leprosy . Int J Dermatol 1974;13:20-25.Crossref 20. Hastings RC, Morales MJ, Shannon EJ: Studies on the mechanism of action of thalidomide in leprosy . Pharmacologist 1976;18:218-221. 21. Saläun J: L'action tératogène de la thalidomide . Ann Biol Clin 1968;7:307-326. 22. Roath S, Elves MW, Israels MCG: Effects of thalidomide and its derivates on human leucocytes cultured in vitro . Lancet 1963;1:249-250.Crossref 23. Faure M, Thivolet J, Gaucherand M: Inhibition of PMN leucocytes chemotaxis by thalidomide . Arch Dermatol Res 1980;269:275-280.Crossref 24. Lutwak-Mann C: Observations on progeny of thalidomide-treated male rabbits . Br Med J 1964;1:1090-1091.Crossref 25. Lutwak-Mann C, Schmid K, Keberle H: Thalidomide in rabbit semen . Nature 1967;214:1018-1020.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1983

References