Abstract Recurrent herpes simplex infection, usually benign and self-limited, can present as a chronic destructive process. Three such cases are presented in detail, and a fourth probable case, but without cultural documentation, is briefly described. These have in common, with seven previously reported cases, some form of immunologic impairment. Particular reference is made to the striking incidence of chronic herpes simplex in renal transplant patients undergoing immunosuppression and to the association of the infection with steroid therapy. Topical treatment with idoxuridine was apparently beneficial in two of the four patients. References 1. Kaplan AS: Herpes simplex and pseudorabies viruses , in Virology Monographs . New York, Springger-Verlag, 1969, vol 5, p 46. 2. Ruchman I, Dodd I: Recovery of herpes simplex virus from the blood of a patient with herpetic rhinitis . J Lab Clin Med 35:434-439, 1950. 3. Scott TFM, Tokumaru T: The herpesvirus group , in Horsfall FL, Tamm I (eds): Viral and Rickettsial Diseases of Man , ed 4. Philadelphia, JB Lippincott Co, 1965, p 902. 4. Catalano PM: Broadening spectrum of Herpes-virus hominis (herpes simplex) . Arch Derm 101:364-366, 1970.Crossref 5. Stroud GM: Recurrent herpes simplex and steroid dosage: In a patient with the nephrotic syndrome due to primary systemic amyloidosis . Arch Derm 84:396-401, 1961.Crossref 6. Park RK, Goltz RW, Carey TB: Unusual cutaneous infections associated with immunosuppressive therapy . Arch Derm 95:345-350, 1967.Crossref 7. Montgomerie JZ, Becroft DMO, Croxson MC, et al: Herpes simplex virus infection after renal transplantation . Lancet 2:867-871, 1969.Crossref 8. Bean SF, Fusaro RM: Atypical cutaneous herpes simplex infection associated with acute myelogenous leukemia . Acta Dermatovener 49:94-96, 1969. 9. Dunea G, Nakamoto S, Straffon RA, et al: Renal homotransplantation in 24 patients . Brit Med J 1:7-13, 1965.Crossref 10. Crosby DL, Jones JH, Sussman M: Herpetic naso-oral ulcers after renal transplantation . Lancet 2:1191, 1969.Crossref 11. Wheeler CE Jr, Huffines WD: Primary disseminated herpes simplex of the newborn . JAMA 191:455-460, 1965.Crossref 12. Casazza AR, Duvall CP, Carbone PP: Infection in lymphoma: Histology; treatment, and duration in relation to incidence and survival . JAMA 197:710-716, 1966.Crossref 13. St. Geme JW, Prince JT, Burke BA, et al: Impaired cellular resistance to herpes-simplex virus in Wiskott-Aldrich syndrome . New Eng J Med 273:229-234, 1970.Crossref 14. Lynfield YL, Farhangi M, Runnels JL: Generalized herpes simplex complicating lymphoma . JAMA 207:944-945, 1969.Crossref 15. Becker WB, Kipps A, McKenzie D: Disseminated herpes simplex virus infection: Its pathogenesis based on virological and pathological studies in 33 cases . Amer J Dis Child 115:1-8, 1968.Crossref 16. Rose HM, Molloy E: Cutaneous reactions with the virus of herpes simplex . J Immun 56:287-294, 1947. 17. Douglas RG, Couch RB: Prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans . J Immun 104:289-295, 1970. 18. Andersen HK, Spencer ES: Cytomegalovirus infection among renal allograft recipients . Acta Med Scand 186:7-19, 1969.Crossref 19. Schreiner GE, Maher JF: Uremia: Biochemistry, Pathogenesis and Treatment . Springfield, Ill, Charles C Thomas Publisher, 1961, p 364. 20. Nahmias AJ, Hirsch MS, Kramer JH, et al: Effect of antithymocyte serum on Herpesvirus hominis (type 1) infection in adult mice . Proc Soc Exp Biol Med 132:696-698, 1969.Crossref 21. Criep LH: Clinical Immunology and Allergy , ed 2. New York, Grune & Stratton Inc, 1969. p 291. 22. Kass EH, Hechter O, Mou TW, et al: Effects of adrenal steroids on resistance to infection: Differences in the relative amounts of corticosterone and hydrocortisone secreted and in their biologic effects . Arch Intern Med 96:397-402, 1955.Crossref 23. Miller SP, Shanbrom E: Infectious syndromes of leukemias and lymphomas . Amer J Med Sci 246:420-428, 1963.Crossref 24. Kilbourne ED, Smart KM, Pokorny BA: Inhibition by cortisone of synthesis and action of interferon . Nature 190:650-651, 1961.Crossref 25. Sydiskis RJ, Schultz I: Interferon and antibody production in mice with herpes simplex skin infections . J Infect Dis 116:455-460, 1966.Crossref 26. Glascow, LA, Habel K: Role of polyoma virus and interferon in a herpes simplex virus infection in vitro . Virology 19:328-339, 1963.Crossref 27. Cantell K, Tommila V: Effect of interferon on experimental vaccinia and herpes-simplex virus infections in rabbit eyes . Lancet 2:682-684, 1960.Crossref 28. Park JH, Baron S: Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA . Science 162:811-813, 1968.Crossref 29. Chang LW, Maibach HI, Coleman VR: The effect of hydrocortisone on herpes simplex infected fetal pig skin in organ culture . J Invest Derm 51:262-268, 1968.Crossref 30. Wheeler CE, Harvie EJ, Canby CM: The effect of hydrocortisone on the production of herpes simplex virus in tissue culture . J Invest Derm 36:89-97, 1961. 31. Jawetz E, Okumoto M, Sonne M: Studies on herpes simplex X: The effect of corticosteroids on herpetic keratitis in the rabbit . J Immun 83:486-490, 1959. 32. Dowdle WR, Nahmias AJ, Pauls FP, et al: Association of antigenic type of Herpesvirus hominis with site of viral recovery . J Immunol 99:974-980, 1967. 33. Muller SA, Herrmann EC: Herpes simplex infections in hematologic malignancies . Amer J Med , to be published.
Archives of Dermatology – American Medical Association
Published: Jun 1, 1971