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Chromosome Pairing Error

Chromosome Pairing Error Many of the chromosomal aberrations that cause congenital diseases in man may be the result of an error in chromosome pairing in the germinal cell during meiosis, according to an hypothesis advanced by British geneticist Malcolm A. Ferguson-Smith, MB, MC (Path). The proposal is significant in that it does not postulate the action of a mutagen, such as radiation, to explain many of the observed "spontaneous" aberrations in chromosome structure. These aberrations, according to Dr. Ferguson-Smith, may arise as a result of a chance, but definable, malfunction of the natural process of pairing and crossing over. His hypothesis deals with aberrations at the chromosomal level. It does not refer to mutation occurring as a result of replication error in the DNA molecule. Dr. Ferguson-Smith, senior lecturer in medical genetics at The University of Glasgow, presented his hypothesis at a recent meeting of geneticists in Bar Harbor, Me. He explained it http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Chromosome Pairing Error

JAMA , Volume 197 (10) – Sep 5, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1966.03110100017004
Publisher site
See Article on Publisher Site

Abstract

Many of the chromosomal aberrations that cause congenital diseases in man may be the result of an error in chromosome pairing in the germinal cell during meiosis, according to an hypothesis advanced by British geneticist Malcolm A. Ferguson-Smith, MB, MC (Path). The proposal is significant in that it does not postulate the action of a mutagen, such as radiation, to explain many of the observed "spontaneous" aberrations in chromosome structure. These aberrations, according to Dr. Ferguson-Smith, may arise as a result of a chance, but definable, malfunction of the natural process of pairing and crossing over. His hypothesis deals with aberrations at the chromosomal level. It does not refer to mutation occurring as a result of replication error in the DNA molecule. Dr. Ferguson-Smith, senior lecturer in medical genetics at The University of Glasgow, presented his hypothesis at a recent meeting of geneticists in Bar Harbor, Me. He explained it

Journal

JAMAAmerican Medical Association

Published: Sep 5, 1966

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