Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Many of the chromosomal aberrations that cause congenital diseases in man may be the result of an error in chromosome pairing in the germinal cell during meiosis, according to an hypothesis advanced by British geneticist Malcolm A. Ferguson-Smith, MB, MC (Path). The proposal is significant in that it does not postulate the action of a mutagen, such as radiation, to explain many of the observed "spontaneous" aberrations in chromosome structure. These aberrations, according to Dr. Ferguson-Smith, may arise as a result of a chance, but definable, malfunction of the natural process of pairing and crossing over. His hypothesis deals with aberrations at the chromosomal level. It does not refer to mutation occurring as a result of replication error in the DNA molecule. Dr. Ferguson-Smith, senior lecturer in medical genetics at The University of Glasgow, presented his hypothesis at a recent meeting of geneticists in Bar Harbor, Me. He explained it
JAMA – American Medical Association
Published: Sep 5, 1966
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.