STUDY Chromosomal Aberrations by 4-Color Fluorescence In Situ Hybridization Not Detected in Spitz Nevi of Older Individuals Basil A. Horst, MD, DrMed; Yuqiang Fang, MD; David N. Silvers, MD; Klaus J. Busam, MD Objective: To investigate whether Spitz nevi with typi- cal of Spitz nevi. FISH was performed on samples with cal histopathological features in older patients demon- typical histopathological features by a 4-color FISH probe strate chromosomal aberrations by 4-color fluorescence set used for the evaluation of malignant melanocytic neo- in situ hybridization (FISH). plasms. Design: Retrospectivemedicalrecordreview,withprospec- Results: None of the study cases showing histopatho- tive masked histopathological and cytogenetic analyses. logical features typical of Spitz nevi had detectable chro- mosomal abnormalities by FISH. Setting: University-affiliated dermatology and derma- topathology setting. Conclusions: Spitz nevi in older patients demonstrate molecular features similar to those of Spitz nevi in younger Patients: Twenty-five patients 50 years or older with age groups. The findings of normal karyotypes in com- melanocytic nevi showing histopathological features typi- bination with typical histopathological features are re- cal of Spitz nevi. assuring of Spitz nevus diagnoses in older patients and suggest no correlation of increased malignant potential Main Outcome Measures: Three dermatopatholo- with advanced age per se.
JAMA Dermatology – American Medical Association
Published: Oct 1, 2012
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