Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Chromomycosis: Treatment With Thiabendazole

Chromomycosis: Treatment With Thiabendazole Abstract Fourteen patients with chromomycosis have been treated orally with thiabendazole, either alone or in combination with surgery. Apparent cures have been obtained in five according to the criteria considered mandatory. The drug is well tolerated in the majority of cases with only minor symptoms of nausea and headache occurring at higher dosage levels. A hypersensitivity reaction, not previously recorded, developed in several patients, manifested by elevated serum bilirubin and transaminase values. The need for regular laboratory investigations is stressed. The problems and consequences of surgical intervention, including biopsies, may be due to the role of trauma in reactivating the infection. It is concluded that, at present, thiabendazole warrants a definite place in the treatment of chromomycosis. References 1. Carrion AL: Chromoblastomycosis . Ann NY Acad Sci 50:1255, 1950.Crossref 2. Pardo-Costello V, Rio Leon E, Trespalacios F: Chromoblastomycosis in Cuba . Arch Derm Syph 45:19-32, 1942.Crossref 3. Romero A, Trejos A: La cromoblastomycosis en Costa Rica . Rev Biol Trop 1:95-115, 1953. 4. Ive FA, Clark BM: Chromomycosis in Nigeria . J Trop Med Hyg 69:184-186, 1966. 5. Gonzalez-Ochoa A: Griseofulvin in deep mycoses . Ann NY Acad Sci 89:17-29, 1960. 6. Costello MJ, DeFeo CP, Littman ML: Chromoblastomycosis treated with local infiltration of amphotericin B solution . Arch Derm 79:184-193, 1959.Crossref 7. Derbes VJ, Friedman L, Krafchuk JD: Chromoblastomycosis treated by vibrapuncture injection of amphotericin B . Arch Derm 80:286-287, 1959.Crossref 8. DeFeo CP, Harber LC: Chromoblastomycosis treated with local infiltration of amphotericin-B solution . JAMA 171:1961-1963, 1959.Crossref 9. Timokhowski A: Intrafocal administration of amphotericin-B in the treatment of chromomycosis . Vestn Derm Vener 4:48-52, 1963. 10. Whiting DA: Treatment of chromoblastomycosis with high local concentrations of amphotericin-B . Brit J Derm 79:345-351, 1967.Crossref 11. Silva M: The saprophytic phase of the fungi of chromomycosis: Effect of nutrients and temperature upon growth and morphology . Trans NY Acad Sci 21:46-57, 1958.Crossref 12. Mackinnon JE: Revision sobre observaciones experimentales y humanas, demostrativas del efecto de la temperatura en algunas micosis . Torax 13:266-270, 1964. 13. Conti-Diaz IA: Temperaturas maximales de agentes de micetomas y cromoblastomicosis . An Fac Med Montev 50:190-196, 1965. 14. Dodin A, Moreau M: Inhibition in vitro par le dimethyl-dithiocarbamate de zinc de la germination des spores de champignons responsables de la chromoblastomycose humaine . Arch Inst Pasteur Madagascar 34:39-40, 1965. 15. Le Quellec B, Dodin A, Moreau M: Essais de fongicides dérivés du diméthyl-dithiocarbamate de zinc in vitro et in vivo dans la chromoblastomycose humaine . Bull Soc Path Exot 59:192-199, 1966. 16. Blank H, Rebell G: Thiabendazole activity against the fungi of dermatophytosis, mycetoma and chromomycosis . J Invest Derm 44:219-220, 1965. 17. Cordero FA: Thiabendazole "cure" of chromomycosis . The Shoch Letter: Current News in Dermatology , item 39, 1965. 18. Solano AE: Tratamiento de la cromoblastomicosis con thiabendazole . Med Cutan 3:277-286, 1966. 19. Robinson HJ, Stoerck HC, Graessle OF: Studies on toxicologic and pharmacologic properties of thiabendazole . Toxic Appl Pharmacol 7:53-63, 1965.Crossref 20. Caplan RM: Epidermoid carcinoma arising in extensive chromoblastomycosis . Arch Derm 97:38-41, 1968.Crossref 21. Battistini F, Sierra RN: Tratamiento de un caso de cromomicosis con applicaciones locales de thiabendaole . Rev Derm Ven 7:3-10, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Chromomycosis: Treatment With Thiabendazole

Archives of Dermatology , Volume 104 (5) – Nov 1, 1971

Loading next page...
 
/lp/american-medical-association/chromomycosis-treatment-with-thiabendazole-6rMEZ60hau
Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1971.04000230018003
Publisher site
See Article on Publisher Site

Abstract

Abstract Fourteen patients with chromomycosis have been treated orally with thiabendazole, either alone or in combination with surgery. Apparent cures have been obtained in five according to the criteria considered mandatory. The drug is well tolerated in the majority of cases with only minor symptoms of nausea and headache occurring at higher dosage levels. A hypersensitivity reaction, not previously recorded, developed in several patients, manifested by elevated serum bilirubin and transaminase values. The need for regular laboratory investigations is stressed. The problems and consequences of surgical intervention, including biopsies, may be due to the role of trauma in reactivating the infection. It is concluded that, at present, thiabendazole warrants a definite place in the treatment of chromomycosis. References 1. Carrion AL: Chromoblastomycosis . Ann NY Acad Sci 50:1255, 1950.Crossref 2. Pardo-Costello V, Rio Leon E, Trespalacios F: Chromoblastomycosis in Cuba . Arch Derm Syph 45:19-32, 1942.Crossref 3. Romero A, Trejos A: La cromoblastomycosis en Costa Rica . Rev Biol Trop 1:95-115, 1953. 4. Ive FA, Clark BM: Chromomycosis in Nigeria . J Trop Med Hyg 69:184-186, 1966. 5. Gonzalez-Ochoa A: Griseofulvin in deep mycoses . Ann NY Acad Sci 89:17-29, 1960. 6. Costello MJ, DeFeo CP, Littman ML: Chromoblastomycosis treated with local infiltration of amphotericin B solution . Arch Derm 79:184-193, 1959.Crossref 7. Derbes VJ, Friedman L, Krafchuk JD: Chromoblastomycosis treated by vibrapuncture injection of amphotericin B . Arch Derm 80:286-287, 1959.Crossref 8. DeFeo CP, Harber LC: Chromoblastomycosis treated with local infiltration of amphotericin-B solution . JAMA 171:1961-1963, 1959.Crossref 9. Timokhowski A: Intrafocal administration of amphotericin-B in the treatment of chromomycosis . Vestn Derm Vener 4:48-52, 1963. 10. Whiting DA: Treatment of chromoblastomycosis with high local concentrations of amphotericin-B . Brit J Derm 79:345-351, 1967.Crossref 11. Silva M: The saprophytic phase of the fungi of chromomycosis: Effect of nutrients and temperature upon growth and morphology . Trans NY Acad Sci 21:46-57, 1958.Crossref 12. Mackinnon JE: Revision sobre observaciones experimentales y humanas, demostrativas del efecto de la temperatura en algunas micosis . Torax 13:266-270, 1964. 13. Conti-Diaz IA: Temperaturas maximales de agentes de micetomas y cromoblastomicosis . An Fac Med Montev 50:190-196, 1965. 14. Dodin A, Moreau M: Inhibition in vitro par le dimethyl-dithiocarbamate de zinc de la germination des spores de champignons responsables de la chromoblastomycose humaine . Arch Inst Pasteur Madagascar 34:39-40, 1965. 15. Le Quellec B, Dodin A, Moreau M: Essais de fongicides dérivés du diméthyl-dithiocarbamate de zinc in vitro et in vivo dans la chromoblastomycose humaine . Bull Soc Path Exot 59:192-199, 1966. 16. Blank H, Rebell G: Thiabendazole activity against the fungi of dermatophytosis, mycetoma and chromomycosis . J Invest Derm 44:219-220, 1965. 17. Cordero FA: Thiabendazole "cure" of chromomycosis . The Shoch Letter: Current News in Dermatology , item 39, 1965. 18. Solano AE: Tratamiento de la cromoblastomicosis con thiabendazole . Med Cutan 3:277-286, 1966. 19. Robinson HJ, Stoerck HC, Graessle OF: Studies on toxicologic and pharmacologic properties of thiabendazole . Toxic Appl Pharmacol 7:53-63, 1965.Crossref 20. Caplan RM: Epidermoid carcinoma arising in extensive chromoblastomycosis . Arch Derm 97:38-41, 1968.Crossref 21. Battistini F, Sierra RN: Tratamiento de un caso de cromomicosis con applicaciones locales de thiabendaole . Rev Derm Ven 7:3-10, 1968.

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1971

References