Abstract The effects of autonomic agents on the choroidal circulation were studied by the radioactive krypton desaturation technique in anesthetized cats. Levarterenol, epinephrine, and acetylcholine, when administered locally via the lateral long posterior ciliary artery (LLPCA), caused the anticipated changes in choroidal vascular resistance (CVR), and corresponding changes in choroidal blood flow (CBF). When administered systemically via the femoral artery, the changes in the mean arterial pressure (MAP) tended to mask any changes in CVR resulting in an opposite effect on CBF. Isoproterenol was found to have no effect on CBF when administered via the LLPCA; when injected via the femoral artery, it resulted in a decrease in MAP and CBF without a significant change in CVR. References 1. Friedman E, Chandra SR: Choroidal blood flow: III. Effects of oxygen and carbon dioxide . Arch Ophthal 87:70-71, 1972.Crossref 2. Bill A: Aspects of physiological and pharmacological regulations of uveal blood flow . Acta Soc Med Upsal , 1962, pp 123-134. 3. Trokel S: Effect of respiratory gases upon choroidal hemodynamics . Arch Ophthal 73:838-842, 1965.Crossref 4. Morgan WE, Macri FJ: Vascular responses of the posterior segment of the cat eye . Arch Ophthal 79:779-784, 1968.Crossref 5. Friedman E, Kopald HH, Smith TR: Retinal and choroidal blood flow determined with Kr85 in anesthetized animals . Invest Ophthal 3:539-547, 1964. 6. Ahlquist RP: A study of adrenotropic receptors . Amer J Physiol 153:586-600, 1948. 7. Green HD, Kepchar JG: Control of peripheral resistance in major vascular beds . Physiol Rev 39:617-686, 1959. 8. Goodman LS, Gilman A: Textbook of Pharmacology: Toxicology and Therapeutics . London, Macmillan Co, 1970, p 488.
Archives of Ophthalmology – American Medical Association
Published: Jan 1, 1972
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