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Cholesterol and Violent Behavior

Cholesterol and Violent Behavior Abstract In their recent article,1 Santiago and Dalen focus on the intriguing relationship between low cholesterol levels and violence. They note that Muldoon and colleagues2 suggested that lowering the cholesterol level might trigger behavioral, affective, or nervous system changes, and they, additionally, proposed the use of serotonin as an intermediary. Supporting evidence for this neurotransmitter, however, is meager, which is not surprising as serotonin is more associated with suicide related to depression than with violence. However, the latter is suggestive of increased sympathoadrenal activity, for which there is evidence. As cholesterol is essential for steroid production, reduced availability should result in a negative feedback response involving its tropic hormone, adrenocorticotropin, for which supporting statistics exist.2 Furthermore, in amphibians, cholesterol itself has been shown to downregulate hypothalamo-pituitary-adrenal activity,3 establishing at least a regulatory role in vertebrates. Finally, a more basic point. Survival requires that a falling level of References 1. Santiago JM, Dalen JE. Cholesterol and violent behavior. Arch Intern Med . 1994;154:1317-1321.Crossref 2. Muldoon ME, Manuck SB, Matthews KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ . 1990;301:309-314.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Cholesterol and Violent Behavior

Archives of Internal Medicine , Volume 155 (5) – Mar 13, 1995

Cholesterol and Violent Behavior

Abstract

Abstract In their recent article,1 Santiago and Dalen focus on the intriguing relationship between low cholesterol levels and violence. They note that Muldoon and colleagues2 suggested that lowering the cholesterol level might trigger behavioral, affective, or nervous system changes, and they, additionally, proposed the use of serotonin as an intermediary. Supporting evidence for this neurotransmitter, however, is meager, which is not surprising as serotonin is more associated with suicide...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1995.00430050124016
Publisher site
See Article on Publisher Site

Abstract

Abstract In their recent article,1 Santiago and Dalen focus on the intriguing relationship between low cholesterol levels and violence. They note that Muldoon and colleagues2 suggested that lowering the cholesterol level might trigger behavioral, affective, or nervous system changes, and they, additionally, proposed the use of serotonin as an intermediary. Supporting evidence for this neurotransmitter, however, is meager, which is not surprising as serotonin is more associated with suicide related to depression than with violence. However, the latter is suggestive of increased sympathoadrenal activity, for which there is evidence. As cholesterol is essential for steroid production, reduced availability should result in a negative feedback response involving its tropic hormone, adrenocorticotropin, for which supporting statistics exist.2 Furthermore, in amphibians, cholesterol itself has been shown to downregulate hypothalamo-pituitary-adrenal activity,3 establishing at least a regulatory role in vertebrates. Finally, a more basic point. Survival requires that a falling level of References 1. Santiago JM, Dalen JE. Cholesterol and violent behavior. Arch Intern Med . 1994;154:1317-1321.Crossref 2. Muldoon ME, Manuck SB, Matthews KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ . 1990;301:309-314.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 13, 1995

References