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Chlorthalidone-Induced Hypercalcemia

Chlorthalidone-Induced Hypercalcemia To the Editor.— In the July 15 issue of The Journal (229:267, 1974), Palmer described a patient with hypercalcemia, presumedly secondary to chlorthalidone (Hygroton) administration. Previous reports have shown that thiazides and chlorthalidone can cause permanent hypercalcemia in patients with hyperparathyroidism.1,2 Adams et al3 suggested a provocative test with thiazides for the diagnosis of hyperparathyroidism in patients suffering from nephrolithiasis and hypercalciuria. Since the pharmacological action of chlorthalidone is similar to that of thiazides, we wonder whether the patient described by Palmer has normocalcemic hyperparathyroidism. If that be the case, the observed hypercalcemia may represent a reaction to chlorthalidone in a hyperparathyroid patient. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Chlorthalidone-Induced Hypercalcemia

JAMA , Volume 231 (2) – Jan 13, 1975

Chlorthalidone-Induced Hypercalcemia

Abstract



To the Editor.—
In the July 15 issue of The Journal (229:267, 1974), Palmer described a patient with hypercalcemia, presumedly secondary to chlorthalidone (Hygroton) administration. Previous reports have shown that thiazides and chlorthalidone can cause permanent hypercalcemia in patients with hyperparathyroidism.1,2 Adams et al3 suggested a provocative test with thiazides for the diagnosis of hyperparathyroidism in patients suffering from nephrolithiasis and hypercalciuria.
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1975.03240140008004
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— In the July 15 issue of The Journal (229:267, 1974), Palmer described a patient with hypercalcemia, presumedly secondary to chlorthalidone (Hygroton) administration. Previous reports have shown that thiazides and chlorthalidone can cause permanent hypercalcemia in patients with hyperparathyroidism.1,2 Adams et al3 suggested a provocative test with thiazides for the diagnosis of hyperparathyroidism in patients suffering from nephrolithiasis and hypercalciuria. Since the pharmacological action of chlorthalidone is similar to that of thiazides, we wonder whether the patient described by Palmer has normocalcemic hyperparathyroidism. If that be the case, the observed hypercalcemia may represent a reaction to chlorthalidone in a hyperparathyroid patient.

Journal

JAMAAmerican Medical Association

Published: Jan 13, 1975

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